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Author: Nigel West
Publisher:
ISBN: 9780300123470
Category : Espionage, Soviet
Languages : en
Pages : 0
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Book Description
Reveals the nature and extent of the damage done to the British intelligence establishment during the Second World War by the 'Cambridge Five' spy ring: Kim Philby, Donald Maclean, Guy Burgess, Anthony Blunt and John Cairncross.
Author: Nigel West
Publisher:
ISBN: 9780300123470
Category : Espionage, Soviet
Languages : en
Pages : 0
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Book Description
Reveals the nature and extent of the damage done to the British intelligence establishment during the Second World War by the 'Cambridge Five' spy ring: Kim Philby, Donald Maclean, Guy Burgess, Anthony Blunt and John Cairncross.
Author: Tomislav Vignjević
Publisher: Cambridge Scholars Publishing
ISBN: 1527537005
Category : Art
Languages : en
Pages : 162
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Book Description
This volume highlights the copious and various depictions of the three orders of society during the Late Middle Ages and at the beginning of the Early Modern Period. It discusses the origins and development of the trifunctional division into the orders of the oratores, bellatores and laboratores, and the abundantly preserved visual material, which proves that this scheme was one of the most widespread ideological foundations of European societies at that time. Late Gothic and Renaissance depictions of the three orders of society can be found in different mediums, from woodcuts to wall paintings, and were produced by important artists such as J. Fouquet and Pieter Bruegel, as well as anonymous painters. The vast numbers of preserved examples of this topic confirm the significance and strength of this iconographic theme at the end of the Middle Ages.
Author: Iowa Engineering Experiment Station
Publisher:
ISBN:
Category :
Languages : en
Pages : 792
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Book Description
Author:
Publisher:
ISBN:
Category : Engineering
Languages : en
Pages : 1098
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Book Description
Author: Richard R. Sinden
Publisher: Elsevier
ISBN: 0080571735
Category : Science
Languages : en
Pages : 423
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Book Description
DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics. - Explains basic DNA Structure and function clearly and simply - Contains up-to-date coverage of cruciforms, Z-DNA, triplex DNA, and other DNA conformations - Discusses DNA-protein interactions, chromosomal organization, and biological implications of structure - Highlights key experiments and ideas within boxed sections - Illustrated with 150 diagrams and figures that convey structural and experimental concepts
Author: Martine Demeunynck
Publisher: John Wiley & Sons
ISBN: 3527605665
Category : Science
Languages : en
Pages : 754
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Book Description
The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.
Author: Eugen Stulz
Publisher: John Wiley & Sons
ISBN: 111869693X
Category : Technology & Engineering
Languages : en
Pages : 538
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Book Description
This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential electronic devices. The book combines many aspects of DNA nanotechnology, including formation of functional structures based on covalent and non-covalent systems, DNA origami, DNA based switches, DNA machines, and alternative structures and templates. This broad coverage is very appealing since it combines both the synthesis of modified DNA as well as designer concepts to successfully plan and make DNA nanostructures. Contributing authors have provided first a general introduction for the non-specialist reader, followed by a more in-depth analysis and presentation of their topic. In this way the book is attractive and useful for both the non-specialist who would like to have an overview of the topic, as well as the specialist reader who requires more information and inspiration to foster their own research.
Author: Rajnikant Mishra
Publisher: BoD – Books on Demand
ISBN: 9535107070
Category : Science
Languages : en
Pages : 260
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Book Description
The complexity of problem understanding biochemical and molecular basis of healthy life, and eagerness to find simple solution necessitate evolution of technology like mutagenesis. The chapters of this book contain experiences of scientists working in the area of mutagenesis. It describes suitable experimental models (microorganism, plants or animals) for testing spontaneous and induced mutations which are useful for basic and translational research. It includes methods towards gene targeting, developing disease and pest resistant plants, creating temperature sensitive molecular machines, understanding mitochondrial mutagenesis, detecting anti-mutagens, improving genetic insight into impaired immunity and disease. It also describes mutagenesis induced by DNA damage. It has also provided advantage of in vitro transcription and translation to yield proteins with point mutations, deletions or insertions for studying stability, DNA-protein or protein-protein interaction. Trust, it will serve readers as valuable integrated resources emphasizing methods of mutagenesis, and understanding mechanism of variable penetrance or expressivity of mutations.
Author:
Publisher: Elsevier
ISBN: 0080458203
Category : Science
Languages : en
Pages : 407
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Book Description
Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.High quality comprehensive reviews covering all aspects of carbohydrate chemistry
Author: Zutao YU
Publisher: Springer Nature
ISBN: 9811544239
Category : Science
Languages : en
Pages : 145
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Book Description
This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole–imidazole polyamides (PIPs). PIPs represent the best-characterized class of small molecule DNA binders that can be modified to bind with any predetermined DNA sequence and regulate gene expression patterns in a transgene-free and cost-effective manner. PIPs are characterized by their small molecular size, high binding affinity, programmability, sequence selectivity, and moderate cell permeability. In recent years, there have been numerous novel studies on the applications of these biological tools; this research is thoroughly reviewed in the first chapter. There are several critical issues, however, that impede the further broad study of PIPs, which greatly concern the author. For instance, the short PIP version has an excessively hi^10 bp; this significantly decreases cell permeability. Moreover, the conventional binding strategy for PIP design cannot apply to flexible DNA binding—for example, the DNA-binding mode of a transcription factor pair. In this book, the author describes the development of three kinds of cooperative DNA-binding systems that help resolve the current highly problematic issues concerning PIPs. These three systems offer a range of significant advantages, such as favorable sequence selectivity, long recognition sequence, higher binding affinity, and a flexible gap distance. Released at a critical juncture in the application of PIPs, this book will greatly facilitate their use as therapeutic drugs in the treatment of cancer and hereditary diseases, and in regenerative medicine.
