Clinical Trial Design PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Clinical Trial Design PDF full book. Access full book title Clinical Trial Design by Guosheng Yin. Download full books in PDF and EPUB format.
Author: Guosheng Yin
Publisher: John Wiley & Sons
ISBN: 0470581719
Category : Medical
Languages : en
Pages : 368
Get Book Here
Book Description
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Author: DALLAS. MACK
Publisher:
ISBN: 9780779896769
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Erik Nielson
Publisher: The New Press
ISBN: 1620973413
Category : Social Science
Languages : en
Pages : 223
Get Book Here
Book Description
A groundbreaking exposé about the alarming use of rap lyrics as criminal evidence to convict and incarcerate young men of color Should Johnny Cash have been charged with murder after he sang, "I shot a man in Reno just to watch him die"? Few would seriously subscribe to this notion of justice. Yet in 2001, a rapper named Mac whose music had gained national recognition was convicted of manslaughter after the prosecutor quoted liberally from his album Shell Shocked. Mac was sentenced to thirty years in prison, where he remains. And his case is just one of many nationwide. Over the last three decades, as rap became increasingly popular, prosecutors saw an opportunity: they could present the sometimes violent, crime-laden lyrics of amateur rappers as confessions to crimes, threats of violence, evidence of gang affiliation, or revelations of criminal motive—and judges and juries would go along with it. Detectives have reopened cold cases on account of rap lyrics and videos alone, and prosecutors have secured convictions by presenting such lyrics and videos of rappers as autobiography. Now, an alarming number of aspiring rappers are imprisoned. No other form of creative expression is treated this way in the courts. Rap on Trial places this disturbing practice in the context of hip hop history and exposes what's at stake. It's a gripping, timely exploration at the crossroads of contemporary hip hop and mass incarceration.
Author: Daniel I. Small
Publisher: American Bar Association
ISBN: 9781570737237
Category : Law
Languages : en
Pages : 326
Get Book Here
Book Description
Classic reference with accessible and proven advice on how to better prepare for trial, from the first client interview to closing argument. Includes numerous procedures, checklists, forms, and worksheets.
Author: John W. Mauck
Publisher: Thomas Nelson
ISBN: 9780785245988
Category : Bible
Languages : en
Pages : 0
Get Book Here
Book Description
JOHN W. MAUCK provides an exciting new way of understanding the Book of Acts. With great skill and powerful arguments, the author contends that Acts was written primarily to defend Paul for his forthcoming trial in Rome. After reading Mauck's volume, the read we will not only gain a fuller understanding of Acts, but also obtain rock-solid arguments for defending Christianity and understanding its Jewish roots. What's Inside: A fresh study of Acts as a legal "brief" Insights gained from understanding of Roman law Numerous Charts that outline Luke's "argument" Recorded speeches viewed as "witness testimony" A section-by-section review of all of Acts A powerful apologetic defending the claims of Christianity Endorsements: "The book is a terrific addition to any lawyer's library. It makes the Book of Acts come alive with new and useful insights." -- Samuel B. Casey, Executive Director, Christian Legal Society "It makes a constructive, fresh, and fascinating contribution to the understanding of Acts." -- Dr. Donald Hagner, Author of Matthew in WBC, Fuller Theological Seminary
Author: Scott Turow
Publisher: Grand Central Publishing
ISBN: 1538748088
Category : Fiction
Languages : en
Pages : 393
Get Book Here
Book Description
Two formidable men collide in this "first-class legal thriller" and New York Times bestseller about a celebrated criminal defense lawyer and the prosecution of his lifelong friend -- a doctor accused of murder (David Baldacci). At eighty-five years old, Alejandro "Sandy" Stern, a brilliant defense lawyer with his health failing but spirit intact, is on the brink of retirement. But when his old friend Dr. Kiril Pafko, a former Nobel Prize winner in Medicine, is faced with charges of insider trading, fraud, and murder, his entire life's work is put in jeopardy, and Stern decides to take on one last trial. In a case that will be the defining coda to both men's accomplished lives, Stern probes beneath the surface of his friend's dazzling veneer as a distinguished cancer researcher. As the trial progresses, he will question everything he thought he knew about his friend. Despite Pafko's many failings, is he innocent of the terrible charges laid against him? How far will Stern go to save his friend, and -- no matter the trial's outcome -- will he ever know the truth? Stern's duty to defend his client and his belief in the power of the judicial system both face a final, terrible test in the courtroom, where the evidence and reality are sometimes worlds apart. Full of the deep insights into the spaces where the fragility of human nature and the justice system collide, Scott Turow's The Last Trial is a masterful legal thriller that unfolds in page-turning suspense -- and questions how we measure a life.
Author: Jean Bethke Elshtain
Publisher: House of Anansi
ISBN: 0887848540
Category : Political Science
Languages : en
Pages : 162
Get Book Here
Book Description
Is democracy as we know it in danger? More and more we confront one another as aggrieved groups rather than as free citizens. Deepening cynicism, the growth of corrosive individualism, statism, and the loss of civil society are warning signs that democracy may be incapable of satisfying the yearnings it itself unleashes - yearnings for freedom, fairness, and equality. In her 1993 CBC Massey Lectures, political philosopher Jean Bethke Elshtain delves into these complex issues to evaluate democracy's chances for survival.
Author: Deborah E. Lipstadt
Publisher: Schocken
ISBN: 0805242910
Category : History
Languages : en
Pages : 240
Get Book Here
Book Description
***NATIONAL JEWISH BOOK AWARD FINALIST (2012)*** Part of the Jewish Encounter series The capture of SS Lieutenant Colonel Adolf Eichmann by Israeli agents in Argentina in May of 1960 and his subsequent trial in Jerusalem by an Israeli court electrified the world. The public debate it sparked on where, how, and by whom Nazi war criminals should be brought to justice, and the international media coverage of the trial itself, was a watershed moment in how the civilized world in general and Holocaust survivors in particular found the means to deal with the legacy of genocide on a scale that had never been seen before. Award-winning historian Deborah E. Lipstadt gives us an overview of the trial and analyzes the dramatic effect that the survivors’ courtroom testimony—which was itself not without controversy—had on a world that had until then regularly commemorated the Holocaust but never fully understood what the millions who died and the hundreds of thousands who managed to survive had actually experienced. As the world continues to confront the ongoing reality of genocide and ponder the fate of those who survive it, this trial of the century, which has become a touchstone for judicial proceedings throughout the world, offers a legal, moral, and political framework for coming to terms with unfathomable evil. Lipstadt infuses a gripping narrative with historical perspective and contemporary urgency.
Author: Franz Kafka
Publisher: Harvill Secker
ISBN: 9780706405712
Category : German fiction
Languages : en
Pages : 925
Get Book Here
Book Description
This volume contains the great works of fiction as well as the complete diaries and thus gives the reader considrable insight into the mind of this strange and powerful man.
Author: Guosheng Yin
Publisher: John Wiley & Sons
ISBN: 0470581719
Category : Medical
Languages : en
Pages : 368
Get Book Here
Book Description
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Author: Karl E. Peace
Publisher: CRC Press
ISBN: 1584889187
Category : Mathematics
Languages : en
Pages : 422
Get Book Here
Book Description
Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide a valid inference about the objective of the trial. Drawing from the authors' courses on the subject as well as the first author's more than 30 years wor
