Author: Stéphane Martin
Publisher: Springer Nature
ISBN: 1071625691
Category : Medical
Languages : en
Pages : 271
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Book Description
This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experimental approaches to genetically engineer macaque models of NDDs and investigate how genetic predisposition may cause neural and functional alterations. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Research Methods in Neurodevelopmental Disorders is a valuable resource for all researchers who want to learn more about this important and developing field.
Author: Mustafa Sahin
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: David B. Arciniegas
Publisher: Cambridge University Press
ISBN: 0521875013
Category : Medical
Languages : en
Pages : 685
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Book Description
The merger of behavioral neurology and neuropsychiatry into a single medical subspecialty, Behavioral Neurology & Neuropsychiatry, requires an understanding of brain-behavior relationships and a clinical approach that transcends the traditional perspectives of neurology and psychiatry. Designed as a primer of concepts and principles, and authored by a multidisciplinary group of internationally known clinical neuroscientists, this book divides into three sections: • Structural and Functional Neuroanatomy (Section I) addresses the neuroanatomy and phenomenology of cognition, emotion, and behavior • Clinical Assessment (Section II) describes neuropsychiatric history taking, neurological and mental status examinations, neuropsychological assessment, and neuroimaging, electrophysiologic, and laboratory methods • Treatment (Section III) discusses environmental, behavioral, rehabilitative, psychological, social, pharmacological, and procedural interventions for cognitive, emotional, and behavioral disorders. By emphasizing the principles of Behavioral Neurology & Neuropsychiatry, this book will improve your understanding of brain-behavior relationships and inform your care of patients and families affected by neurobehavioral disorders.
Author: Josephine Johns
Publisher: Frontiers Media SA
ISBN: 2889190455
Category :
Languages : en
Pages : 360
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Book Description
The disruption of mother-infant interactions can have life-long detrimental consequences for offspring and mothers. This topic of Frontiers will focus on maternal-infant interactions including factors that may affect or alter infant or child development and maternal response capability in clinical and preclinical (animal) populations. Articles may highlight topics such as drug abuse, maternal neglect, altered reward systems, stress, biological and neural system development, child and infant behavioral development, genetics/epigenetics and intergenerational studies. Submissions can include research methods papers, reviews, original research articles, techniques and opinion articles that address the topics of interest. This Research Topic will highlight translational research including common measures and results found in both animal and human studies. Please contact one of the Editors for submission proposals or for additional information.
Author: Roya Kelishadi
Publisher: Springer Nature
ISBN: 9819774330
Category :
Languages : en
Pages : 138
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Book Description
Author: Stefan M Brudzynski
Publisher: Academic Press
ISBN: 0128097736
Category : Science
Languages : en
Pages : 582
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Book Description
Handbook of Ultrasonic Vocalization: Window into the Mammalian Brain, Volume 25, is an exhaustive resource on ultrasonic vocalizations in vertebrates, providing full coverage of all aspects of these vocalizations. The book also demonstrates the usefulness of ultrasonic vocalizations in studies of animal communication, sociobiological states, and in mammalian models of affective disorders, addictions and neurodevelopmental disorders, making it an indispensable resource for researchers using animal models. The book begins with the evolution of vocal communication before discussing mechanisms of ultrasound production, perception and the brain systems involved in emotional arousal that are responsible for the generation of vocalization and emotional states. In addition, the book covers studies of neuroactive agents and sociopsychological conditions that can regulate the outcome of ultrasonic vocalization and provide clues about animals' internal states. Critically, the book also includes thorough coverage of pharmacological investigations using ultrasonic vocalizations, increasingly being utilized for studies in affective disorders, psychoses, addiction and alcoholism. No other book provides such extensive coverage of this rapidly growing field of study. - Represents a multidisciplinary approach that incorporates evolution, communication, behavioral homeostasis, emotional expression and neuropsychiatric dysfunction - Provides a systematic review of ultrasonic vocalizations in major groups of rodents widely used in laboratory research - Discusses numerous other species across vertebrates that emit ultrasounds
Author: Ellen Giarelli
Publisher: Charles C Thomas Publisher
ISBN: 0398091013
Category : Family & Relationships
Languages : en
Pages : 423
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Book Description
People with autism spectrum disorder may have unique development challenges, but they face a range of health issues like all people, and many of these may be compounded by an ASD. This book provides the tools and information so the health care professional can think differently about caring for this patient and see through his or her eyes. The presentations of 28 contributors share the importance of early, continuous, coordinated, and individualized care that is integrated into the existing health care system. Examples of models and policies that have improved the access, experience, and outcomes for patients with ASD are shared. In addition, the importance of continuous quality improvement through data collection and monitoring of outcomes is emphasized. This information is essential for addressing the capacity crisis now in providing routine, specialized, and emergency care for individuals with ASD. Some of the major topics discussed include: the epidemiology of autism spectrum disorder; facilitating the role of parents in management and advocacy; the impact of the sensory environment on care; medications for the treatment of psychiatric comorbidities; frameworks to guide practice and research with patients; building a home for acute care needs; assisting parents in adapting and making decisions regarding treatment options; integrating genetic testing into health care; educating nurses with faculty and curricular issues; emergency medicine and improving service; physical therapy to promote health, function, and community participation; using big data to direct quality improvement; and monitoring patient outcomes in research and policy outcomes. This significant volume brings together a wealth of expertise with information and strategies across the lifespan for individuals with autism spectrum disorder.
Author: Kevin J. Mitchell
Publisher: John Wiley & Sons
ISBN: 1118524888
Category : Medical
Languages : en
Pages : 384
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Book Description
Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0128025964
Category : Medical
Languages : en
Pages : 778
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Book Description
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment
Author: Navjot Kaur
Publisher: John Wiley & Sons
ISBN: 1118308255
Category : Science
Languages : en
Pages : 311
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Book Description
Neural stem cells offer a valuable model system for delineating the cellular and developmental processes in normal and diseased states of the central nervous system. In particular, neural stem cells have huge potential in regenerative medicine, owing to their expansion capability in culture and the ability to differentiate into multiple sub-neural lineages. Neural Stem Cell Assays provides a detailed and comprehensive review of the basic methods for neural stem cell cultures. Including an overview of progress in the field over the past decade, Neural Stem Cell Assays is a one-stop reference for consistent methods and reliable tools that span the entire assay work flow, from isolation or generation of neural stem cells to characterization, manipulation and final application of neural stem cells in disease paradigms such as Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis. An excellent source of information for academic, pharmaceutical and biotechnology researchers who are new to the neural stem cell field, Neural Stem Cell Assays is an invaluable to experienced users who wish to integrate newly developed tools and technologies into their workflow. The book also covers important course material for students at the undergraduate and graduate level who are learning the basics of neural stem cell cultures, and differentiation to sub-neural lineages.
