Author: Amelia Casamassimi
Publisher: MDPI
ISBN: 3039212656
Category : Science
Languages : en
Pages : 358
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Book Description
This book is a printed edition of the Special Issue Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation that was published in IJMS
Author: Amelia Casamassimi
Publisher:
ISBN: 9783039212668
Category : Electronic books
Languages : en
Pages : 1
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Book Description
Transcriptional regulation is a critical biological process involved in the response of a cell, a tissue or an organism to a variety of intra- and extra-cellular signals. Besides, it controls the establishment and maintenance of cell identity throughout developmental and differentiation programs. This highly complex and dynamic process is orchestrated by a huge number of molecules and protein networks and occurs through multiple temporal and functional steps. Of note, many human disorders are characterized by misregulation of global transcription since most of the signaling pathways ultimately target components of transcription machinery. This book includes a selection of papers that illustrate recent advances in our understanding of transcriptional regulation and focuses on many important topics, from cis-regulatory elements to transcription factors, chromatin regulators and non-coding RNAs, other than several transcriptome studies and computational analyses.
Author: Brian L. Nelms
Publisher: Morgan & Claypool Publishers
ISBN: 161504048X
Category : Science
Languages : en
Pages : 227
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Book Description
The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types-some of which retain stem cell characteristics presumably to replenish these derivatives-requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies
Author: Carsten Carlberg
Publisher: Springer
ISBN: 9401777411
Category : Medical
Languages : en
Pages : 219
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Book Description
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
Author: Sam Thiagalingam
Publisher: Cambridge University Press
ISBN: 0521493390
Category : Mathematics
Languages : en
Pages : 597
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Book Description
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Author: Sarah C. R. Elgin
Publisher: Frontiers in Molecular Biology
ISBN: 9780199638901
Category : Chromatin
Languages : en
Pages : 372
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Book Description
Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.
Author: Dr. Maslichah Mafruchati drh., M.Si
Publisher: Zifatama Jawara
ISBN: 6238222565
Category : Education
Languages : en
Pages : 133
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Book Description
Buku ini disusun dengan tujuan untuk membantu mahasiswa dalam mempelajari Dasar-Dasar Penelitian Perkembangan Hewan: DNA dan Ekspresi Gen. Buku ini berisi tentang rekombinasi, perbaikan, dan replikasi DNA; Ekspresi Gen: (Transkripsi); Ekspresi Gen: II. (Kode Genetik dan Sintesis Protein)
Author: Benjamin Lewin
Publisher:
ISBN: 9780131449459
Category : Electronic books
Languages : en
Pages : 1027
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Book Description
The unique feature of this book's first edition was the presentation of a unified approach to the molecular biology of prokaryotes and eukaryotes. The success of this approach, and its continuation, is the result of a long string of discoveries showing similarities in solutions to biological problems that often extend across many or even all species. A six-part organization covers genes, proteins, gene expression, DNA, the nucleus, and cells. For individuals in the science community interested in genetics.
Author: Anna Palumbo
Publisher: MDPI
ISBN: 3036504907
Category : Medical
Languages : en
Pages : 140
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Book Description
Sulfur is an essential element for all living organisms and is required by algae, plants, fungi, animals, and humans for growth and development. It is present in a variety of biomolecules involved in many biological functions, including the maintenance of cell redox homeostasis, defense, and detoxifying processes. The alteration of sulfur compound metabolism may lead to human diseases as well as to plant and animal pathologies. The marine environment, which is characterized by a high biodiversity of species and a great chemical diversity, represents a great potential source of bioactive sulfur molecules. A broad range of biologically active sulfur compounds with unique structures and pharmacological properties have been reported to occur in marine organisms, from amino acids to different sulfated derivatives. Great attention is also focused on sulfur metabolites in the marine microbial world in relation to the global sulfur cycle. The aim of this Special Issue is to present existing knowledge and recent studies on sulfur-containing marine bioactive compounds in different biological systems. Attention is also focused on metabolites active at the ecological level.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
