Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression PDF Download
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Author: Martin L. Privalsky
Publisher: Springer Science & Business Media
ISBN: 9783540676119
Category : Medical
Languages : en
Pages : 218
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Book Description
Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.
Author: Martin L. Privalsky
Publisher: Springer Science & Business Media
ISBN: 9783540676119
Category : Medical
Languages : en
Pages : 218
Get Book Here
Book Description
Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.
Author: Martin L. Privalsky
Publisher: Springer Science & Business Media
ISBN: 3662105950
Category : Medical
Languages : en
Pages : 202
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Book Description
Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.
Author: Martin L. Privalsky
Publisher:
ISBN: 9783662105962
Category :
Languages : en
Pages : 212
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Book Description
Author: Athanasios Papavassiliou
Publisher: International Thomson Publishing Services
ISBN:
Category : Medical
Languages : en
Pages : 388
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Book Description
Author: Philip Mark Meneely
Publisher: Oxford University Press
ISBN: 0199681260
Category : Medical
Languages : en
Pages : 580
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Book Description
With its unique integration of genetics and molecular biology, this text probes fascinating questions that explore how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations, the analysis of gene expression and activity, a discussion of the genetic structure of natural populations, and more.
Author: Carsten Carlberg
Publisher: Springer
ISBN: 9401777411
Category : Medical
Languages : en
Pages : 219
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Book Description
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
Author: Ronald C. Conaway
Publisher: Raven Press (ID)
ISBN:
Category : Science
Languages : en
Pages : 600
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Book Description
Presents a coherent account of many productive lines of investigation, organized as a series of mini-reviews that focus on major research areas including studies on the structure and mechanisms of action of bacterial, viral, and eukaryotic RNA polymerases, and the transcription factors that control their activities. Each review provides a brief but up-to-date account of the progress of research in a particular area, a discussion of the major issues and questions driving that research, and a brief description of the evolving approaches and technologies used to address those questions. Annotation copyright by Book News, Inc., Portland, OR
Author: Denis Duboule
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 306
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Book Description
This much-needed guidebook provides research workers with the most up-to-date reference available on homeobox genes. As the tenth anniversary of the discovery of the homeobox fast approaches, these genes are being isolated from an ever-widening group of organisms and are now understood as critical to numerous developmental processes. But the rapidly increasing pool of information on homeobox genes has often resulted in a lack of coordination in the use of nomenclature and classification systems. As a result, the field has been sometimes characterized by its confusing and scattered literature. This book provides an overview of the subject by summarizing the dispersed findings and by listing key references. The first two chapters give a brief historical account of the discovery of the homeobox and introduce the reader to its role in development. The third chapter provides comprehensive coverage to the classification and structural organization of the homeobox genes. Finally, short descriptions of individual homeobox genes are provided in alphabetical order at the end of the book. Guidebook to the Homeobox Genes, with its easy-to-use format, offers a quick and simple way to learn about the essentials of each gene with cogent descriptions and helpful references . It will be welcomed by students and professionals in developmental biology, molecular genetics, and molecular biology.
Author: Edgar Wingender
Publisher: Wiley-Blackwell
ISBN:
Category : Science
Languages : en
Pages : 452
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Book Description
A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control of genetic information. Moreover, it links data on the structure of regulatory proteins with basic cellular processes. Both advanced students and experts will find answers to such intriguing questions as: - How are programs of specific gene repertoires activated and controlled? - Which genes drive and control morphogenesis? - Which genes govern tissue-specific tasks? - How do hormones control gene expression in coordinating the activities of different tissues? An abundant number of clearly presented glossary terms facilitates understanding of the biological background. Speacial feature: over 2200 (!) literature references.
Author: Renato Paro
Publisher: Springer Nature
ISBN: 3030686701
Category : Science
Languages : en
Pages : 219
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Book Description
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
