Author: Claudio Cobelli
Publisher: Springer Science & Business Media
ISBN: 0306468336
Category : Technology & Engineering
Languages : en
Pages : 455
Book Description
1. Introduction. 2. Fundamentals of Tracer Kinetics. 3. The Noncompartmental Model of Multipool Systems. 4. The Compartmental Model. 5. Identifiability of the Tracer Model. 6. Using the Tracer Model to Estimate Kinetic Parameters. 7. Compartmental Versus Noncompartmental Kinetic Parameters. 8. Parameter Estimation: Some Fundamentals of Regression Analysis. 9. Parameter Estimation in Noncompartmental Models. 10. Parameter Estimation in Compartmental Models. 11. Precursor-Product Models. Appendices. Index.
Tracer Kinetics in Biomedical Research
Tracer Kinetics in Biomedical Research
Author: Claudio Cobelli
Publisher:
ISBN: 9781475773279
Category :
Languages : en
Pages : 472
Book Description
Publisher:
ISBN: 9781475773279
Category :
Languages : en
Pages : 472
Book Description
Tracer Kinetics and Physiologic Modeling
Author: R.M. Lambrecht
Publisher: Springer Science & Business Media
ISBN: 3642500366
Category : Mathematics
Languages : en
Pages : 518
Book Description
Publisher: Springer Science & Business Media
ISBN: 3642500366
Category : Mathematics
Languages : en
Pages : 518
Book Description
Tracer Methods for in Vivo Kinetics
Author: Reginald Shipley
Publisher: Elsevier
ISBN: 0323158900
Category : Science
Languages : en
Pages : 254
Book Description
Tracer Methods for In Vivo Kinetics: Theory and Applications summarizes and evaluates the variety of working formulas in applying tracer methods for kinetic studies in vivo. This book discusses the basic concepts, derives the important equations, and evaluates each working formula to ensure its proper application within the set of experimental conditions available. Organized into 12 chapters, this book starts with an overview of tracers such as radioactive atoms. This text then discusses the errors inherent in treating a two-pool system as though it were one pool. Other chapters describe how, from curves of tracer content of the labeled pool or of the secondary pool, a definitive evaluation is made of rate constants and rate of interflow and outflow in the two-pool open system. This book discusses as well the limited usefulness of a curve of specific gravity when information is limited to such a curve obtained from the secondary pool. This book is intended for mathematicians, biomedical scientists, and graduate students.
Publisher: Elsevier
ISBN: 0323158900
Category : Science
Languages : en
Pages : 254
Book Description
Tracer Methods for In Vivo Kinetics: Theory and Applications summarizes and evaluates the variety of working formulas in applying tracer methods for kinetic studies in vivo. This book discusses the basic concepts, derives the important equations, and evaluates each working formula to ensure its proper application within the set of experimental conditions available. Organized into 12 chapters, this book starts with an overview of tracers such as radioactive atoms. This text then discusses the errors inherent in treating a two-pool system as though it were one pool. Other chapters describe how, from curves of tracer content of the labeled pool or of the secondary pool, a definitive evaluation is made of rate constants and rate of interflow and outflow in the two-pool open system. This book discusses as well the limited usefulness of a curve of specific gravity when information is limited to such a curve obtained from the secondary pool. This book is intended for mathematicians, biomedical scientists, and graduate students.
Compartmental Modeling and Tracer Kinetics
Author: David H. Anderson
Publisher:
ISBN: 9783642518621
Category :
Languages : en
Pages : 316
Book Description
Publisher:
ISBN: 9783642518621
Category :
Languages : en
Pages : 316
Book Description
Isotope Tracers in Metabolic Research
Author: Robert R. Wolfe
Publisher: John Wiley & Sons
ISBN: 9780471462095
Category : Medical
Languages : en
Pages : 494
Book Description
In the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease. Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This new Second Edition includes: All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis A completely updated categorized list of over 750 references Major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques The latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics New coverage of mathematical modeling Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies In this complete guide to performing tracer studies, the authors systematically cover tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions highlight key points in each chapter. Isotope Tracers in Metabolic Research, Second Edition offers students and researchers a comprehensive, practical resource for utilizing the latest tracer methodologies.
Publisher: John Wiley & Sons
ISBN: 9780471462095
Category : Medical
Languages : en
Pages : 494
Book Description
In the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease. Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This new Second Edition includes: All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis A completely updated categorized list of over 750 references Major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques The latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics New coverage of mathematical modeling Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies In this complete guide to performing tracer studies, the authors systematically cover tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions highlight key points in each chapter. Isotope Tracers in Metabolic Research, Second Edition offers students and researchers a comprehensive, practical resource for utilizing the latest tracer methodologies.
A Simulation of Tracer Kinetics Data Generation in the Non-steady State Mammalian Fluid System
Author: William Leslie Buford
Publisher:
ISBN:
Category : Tracers (Biology)
Languages : en
Pages : 109
Book Description
Publisher:
ISBN:
Category : Tracers (Biology)
Languages : en
Pages : 109
Book Description
Basic Principles of the Tracer Method
Author: Charles Wilcox Sheppard
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 316
Book Description
It is the purpose of this book to collate and unify the literature on the Tracer Method. Perhaps, as a result, some existing barriers between fields will be overcome with improved communication between workers. It is also hoped that a broader appreciation of the nature of the tracer method and a clearer understanding of its present scope and limitations will be created.
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 316
Book Description
It is the purpose of this book to collate and unify the literature on the Tracer Method. Perhaps, as a result, some existing barriers between fields will be overcome with improved communication between workers. It is also hoped that a broader appreciation of the nature of the tracer method and a clearer understanding of its present scope and limitations will be created.
CFKR
Author: University of Texas at Austin. Center for Fast Kinetics Research
Publisher:
ISBN:
Category : Biomedical engineering
Languages : en
Pages : 12
Book Description
Publisher:
ISBN:
Category : Biomedical engineering
Languages : en
Pages : 12
Book Description
Quantification of Contrast Kinetics in Clinical Imaging
Author: Massimo Mischi
Publisher: Springer
ISBN: 3319646389
Category : Medical
Languages : en
Pages : 184
Book Description
This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.
Publisher: Springer
ISBN: 3319646389
Category : Medical
Languages : en
Pages : 184
Book Description
This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.