Progress in Medicinal Chemistry PDF Download
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Author:
Publisher: Elsevier
ISBN: 0080569684
Category : Science
Languages : en
Pages : 421
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Book Description
Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications) *Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
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Publisher:
ISBN:
Category : American literature
Languages : en
Pages : 16
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Book Description
Author:
Publisher:
ISBN:
Category : American literature
Languages : en
Pages : 82
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Author:
Publisher: Bookboon
ISBN: 8776817318
Category :
Languages : en
Pages : 221
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Book Description
Author: Michael Soldatenko
Publisher: University of Arizona Press
ISBN: 9780816528097
Category : Social Science
Languages : en
Pages : 296
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Book Description
Printbegrænsninger: Der kan printes 10 sider ad gangen og max. 40 sider pr. session
Author:
Publisher: Elsevier
ISBN: 0080569684
Category : Science
Languages : en
Pages : 421
Get Book Here
Book Description
Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications) *Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
Author:
Publisher:
ISBN:
Category : Electric driving, Variable speed
Languages : en
Pages : 714
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Book Description
Author: Frédérick Bastien
Publisher: UBC Press
ISBN: 0774836857
Category : Political Science
Languages : en
Pages : 237
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Book Description
In the thousand-channel universe, politicians must find innovative ways to reach citizens via television. Viewership for news and current affairs television programs has dropped dramatically. Meanwhile, the rise of programming that blends information with entertainment – infotainment – on Canadian television, especially in Quebec, has provided an opportunity for today’s politicians to use it to their advantage. But their appearances on these programs also fuel concerns over the declining authority of journalism in the public sphere. Breaking News? traces the development of infotainment and exposes the impact of these kinds of programs on modern political communication. Frédérick Bastien lays out the issues raised by the eroding influence of existing news gatekeepers and the implications of infotainment for politicians, journalists, and citizens, while arguing that infotainment ultimately makes a positive contribution to democratic life by piquing the audience’s interest in public affairs and motivating it to pay more attention to political news in general.
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Publisher:
ISBN:
Category : Social security
Languages : en
Pages : 6
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Book Description
Author: Michael Milakovich
Publisher: CRC Press
ISBN: 9781884015458
Category : Business & Economics
Languages : en
Pages : 288
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Book Description
Organizations are struggling to improve customer-focused quality in today's highly competitive domestic and global markets. Better design, implementation, and daily management of quality improvement strategies is essential for survival. Quality improvement principles, when thoughtfully applied and appropriately modified to meet all types of customer demands, are a sound means to respond to changing markets. However, when various quality and productivity theories and methods are applied without changing the organizational culture, it is very difficult to consistently deliver quality results. This important new book focuses on quality improvement methods for high performance in public and private services not covered in other books: applications focus on construction, education, government, insurance, public utilities, health care, and nonprofit services. Rather than detailing the technical processes to achieve inspection, planning, quality auditing, statistics, or risk assessment, this book presents step-by-step guidelines, recommendations, and action plans for changing service organizations to implement quality improvements. Sound theory and careful strategic planning are presented to assist readers in developing an understanding of how to select the essential elements of systems that best fit their customers' needs.
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Publisher:
ISBN:
Category : Administrative law
Languages : en
Pages : 1574
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Book Description
