Author: Shayne Cox Gad
Publisher: CRC Press
ISBN: 1420004263
Category : Medical
Languages : en
Pages : 378
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Book Description
Toxicology of the Gastrointestinal Tract focuses on the specifics of the mechanisms and adverse effects of xenobiotic agents and pharmaceuticals on the structure and function of the GI tract. The book focuses on a number of specific areas of intestinal research. Beginning with the well-recognized and major functions of nutrient absorption and its r
Author: Shayne Cox Gad
Publisher: CRC Press
ISBN: 0429781431
Category : Medical
Languages : en
Pages : 303
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Book Description
The gastrointestinal tract is the most important of the three major routes of entry (and clearance) of xenobiotics and biologic entities into the bodies of mammals. As such, it is also the major route for administration of pharmaceuticals to humans. Gastrointestinal Toxicology, Second Edition describes the mechanism for entry and clearance of xenobiotics, as well as the barriers, immunologic and metabolic issues, and functions present in the GI tract. Appearing in this volume are also considerations of the microbiome and its actions and influence on the function of the GI tract and on the toxicity and pharmacodynamics of ingested substances (including nutrients, toxins, and therapeutics). These fifteen chapters written by experienced experts in the field address methods to evaluate GI function; specifics of GI function and toxicity assessment in canines and minipigs; classes of compounds with their toxicity; species differences; and the toxicity (and promise) of nanoparticles. Those needing to understand the structure, function, and methods of studying the GI tract will find this volume a singular source of reference.
Author: Karl Rozman
Publisher: Elsevier Publishing Company
ISBN:
Category : Medical
Languages : en
Pages : 640
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Book Description
Author: Nicolas Bordenave
Publisher: John Wiley & Sons
ISBN: 1118733290
Category : Technology & Engineering
Languages : en
Pages : 335
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Book Description
A much-needed guide to in vitro food functionality evaluation principles, processes, and state-of-the-art modeling There are more than a few books devoted to the assessment of food functionality but, until now, there were no comprehensive guides focusing on the increasingly important subject of in vitro food evaluation. With contributions from the world’s foremost experts in the field, this book brings readers up to speed on the state-of-the-art in in vitro modeling, from its physiological bases to its conception, current uses, and future developments. Food functionality is a broad concept encompassing nutritional and health functionality, food safety and toxicology, as well as a broad range of visual and organoleptic properties of food. In vitro techniques bridge the gap between standard analytical techniques, including chemical and biochemical approaches and in vivo human testing, which remains the ultimate translational goal for evaluation of the functionality of food. Although it is a well- established field, in vitro food testing continues to evolve toward ever more accurate predictions of in vivo properties and outcomes. Both ethical and highly economical, these approaches allow for detailed mechanistic insights into food functionalities and, therefore, a better understanding of the interactions of food and human physiology. Reviews the core concepts of food functionality and functionality evaluation methodologies Provides an overview of the physiology of the gastrointestinal tract, including host-microbial interactions within it Delves into the physiology of sensory perception of food, taste and texture as they relate to in vitro modeling Explores the challenges of linking in vitro analysis of taste, aroma and flavor to their actual perception Addresses in vitro models of the digestion and absorption of macronutrients, micronutrients, and phytonutrients Describes in vitro evaluations of toxicants, allergens and other specific food hazards Functional Foods and Beverages is an indispensable working resource for food scientists as well as researchers working in government facilities dedicated to tracking food safety.
Author: R.S. McCuskey
Publisher: Pergamon
ISBN: 9780080429748
Category : Medical
Languages : en
Pages : 0
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Book Description
This volume, which is separated into two parts, presents important new information concerning mechanisms of effect and consequences of exposure of the liver and gastrointestinal tract to a wide variety of toxicants. Both sections on the liver and GI tract provide the reader with concise introductory descriptions of relevant cellular and organ anatomy, physiology, and mechanisms of toxic injury. Specific consideration is given to methods of toxin exposure and to processes that provide defence against injury. The discussions provide a broad focus but also contain details about molecular, cellular, and biochemical mechanisms. The section on the liver (34 chapters) provides a comprehensive review of the toxic effects of a wide variety of specific compounds including volatile hydrocarbons, anesthetic agents, drugs of therapeutic value as well as of abuse, heavy metals, natural compounds etc. The section on the gastrointestinal tract (15 chapters), presenting toxicology of the esophagus, stomach, small intestine, and colon, represents the first major reference work available that provides both a broad overview of the effect of toxicants on the mucosal, motility, and immune functions of the GI tract as well as specific information about specific toxicants. The final chapter presents an overview of clinical toxicology in animals with specific focus on the liver and gastrointestinal systems. This volume is of specific interest and use to those concerned with environmental and industrial toxicology, as well as with mechanisms of toxicant injury and clinical medicine.
Author: R.S. McCuskey
Publisher: Pergamon
ISBN: 9780080429748
Category : Medical
Languages : en
Pages : 750
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Book Description
This volume, which is separated into two parts, presents important new information concerning mechanisms of effect and consequences of exposure of the liver and gastrointestinal tract to a wide variety of toxicants. Both sections on the liver and GI tract provide the reader with concise introductory descriptions of relevant cellular and organ anatomy, physiology, and mechanisms of toxic injury. Specific consideration is given to methods of toxin exposure and to processes that provide defence against injury. The discussions provide a broad focus but also contain details about molecular, cellular, and biochemical mechanisms. The section on the liver (34 chapters) provides a comprehensive review of the toxic effects of a wide variety of specific compounds including volatile hydrocarbons, anesthetic agents, drugs of therapeutic value as well as of abuse, heavy metals, natural compounds etc. The section on the gastrointestinal tract (15 chapters), presenting toxicology of the esophagus, stomach, small intestine, and colon, represents the first major reference work available that provides both a broad overview of the effect of toxicants on the mucosal, motility, and immune functions of the GI tract as well as specific information about specific toxicants. The final chapter presents an overview of clinical toxicology in animals with specific focus on the liver and gastrointestinal systems. This volume is of specific interest and use to those concerned with environmental and industrial toxicology, as well as with mechanisms of toxicant injury and clinical medicine.
Author: Beverley Greenwood-Van Meerveld
Publisher: Springer
ISBN: 3319563602
Category : Medical
Languages : en
Pages : 446
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Book Description
This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better treatment of patients with GI disorders.
Author: Matthew A. Wallig
Publisher: Academic Press
ISBN: 0080919324
Category : Medical
Languages : en
Pages : 714
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Book Description
Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. - 25% brand new information, fully revised throughout - New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology - New color photomicrographs detailing specific toxicant-induced diseases in animals - Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels
Author: Bradley Hillman
Publisher: CRC Press
ISBN: 1482272482
Category : Medical
Languages : en
Pages : 301
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Book Description
An examination of the composition and metabolic activity of microorganisms commonly found in the human gut. Chapters cover the effects gut flora have on ingested compounds, vitamin production and gastrointestinal disorders. Comparisons are also made between microbial and mammalian metabolism.
Author:
Publisher: Elsevier
ISBN: 0080468845
Category : Medical
Languages : en
Pages : 6448
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Book Description
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
