Towards Motion-insensitive Arterial Spin Labeling Perfusion Imaging PDF Download
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Author: Jörn Huber
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Perfusion measurements in brain and liver are of high clinical interest. Arterial spin labeling (ASL) magnetic resonance imaging (MRI) has the potential to be an alternative to invasive measurements of perfusion using contrast agent-based techniques. However, the clinical application of ASL is currently limited due to a severe sensitivity to subject motion. The goal of this thesis was to develop novel methods which address the motion sensitivity of ASL sequences. The developed techniques include novel optimized approaches for background suppression, an automatic detection of breathholds during ASL experiments to suppress respiratory motion artifacts, prospective correction of respiratory motion during free-breathing scans as well as three-dimensional retrospective motion correction using a 3D GRASE PROPELLER (3DGP) readout. In addition, a novel 3DGP reconstruction, allowing joint estimation of motion and geometric distortion, is presented. Algorithms are implemented and validated in brain and liver ASL perfusion imaging using healthy volunteers. Finally, recommendations for future improvements of the developed techniques are given.
Author: Jörn Huber
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Perfusion measurements in brain and liver are of high clinical interest. Arterial spin labeling (ASL) magnetic resonance imaging (MRI) has the potential to be an alternative to invasive measurements of perfusion using contrast agent-based techniques. However, the clinical application of ASL is currently limited due to a severe sensitivity to subject motion. The goal of this thesis was to develop novel methods which address the motion sensitivity of ASL sequences. The developed techniques include novel optimized approaches for background suppression, an automatic detection of breathholds during ASL experiments to suppress respiratory motion artifacts, prospective correction of respiratory motion during free-breathing scans as well as three-dimensional retrospective motion correction using a 3D GRASE PROPELLER (3DGP) readout. In addition, a novel 3DGP reconstruction, allowing joint estimation of motion and geometric distortion, is presented. Algorithms are implemented and validated in brain and liver ASL perfusion imaging using healthy volunteers. Finally, recommendations for future improvements of the developed techniques are given.
Author: Michael Chappell
Publisher: Oxford University Press
ISBN: 0198793812
Category : Medical
Languages : en
Pages : 157
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Book Description
ASL is an increasingly popular tool to study the brain. The aim of this primer is to equip someone new to the field with the knowledge to make informed choices about ASL acquisition and analysis. While providing a stand-alone introduction to this subject, the text can be read with others in the series for a comprehensive overview of neuroimaging.
Author: Richard B. Buxton
Publisher: Cambridge University Press
ISBN: 1139481304
Category : Medical
Languages : en
Pages : 479
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Book Description
Functional Magnetic Resonance Imaging (fMRI) has become a standard tool for mapping the working brain's activation patterns, both in health and in disease. It is an interdisciplinary field and crosses the borders of neuroscience, psychology, psychiatry, radiology, mathematics, physics and engineering. Developments in techniques, procedures and our understanding of this field are expanding rapidly. In this second edition of Introduction to Functional Magnetic Resonance Imaging, Richard Buxton – a leading authority on fMRI – provides an invaluable guide to how fMRI works, from introducing the basic ideas and principles to the underlying physics and physiology. He covers the relationship between fMRI and other imaging techniques and includes a guide to the statistical analysis of fMRI data. This book will be useful both to the experienced radiographer, and the clinician or researcher with no previous knowledge of the technology.
Author: Denis Le Bihan
Publisher: CRC Press
ISBN: 0429763484
Category : Medical
Languages : en
Pages : 718
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Book Description
Intravoxel incoherent motion (IVIM) refers to translational movements which within a given voxel and during the measurement time present a distribution of speeds in orientation and/or amplitude. The concept was introduced in 1986 together with the foundation of diffusion MRI because it had been realized that flow of blood in capillaries (perfusion) would mimic a diffusion process and impact diffusion MRI measurements. IVIM-based perfusion MRI, which does not require injection of any tracer or contrast agent, has been first investigated in the brain, but is now experiencing a remarkable revival for applications throughout the body, especially for oncologic applications, from diagnosis to treatment monitoring. This book addresses a number of highly topical aspects of the field from leading authorities, introducing the concepts behind IVIM MRI, outlining related methodological issues, and summarizing its current usage and potential for clinical applications. It also presents future research directions, both in terms of methodological development and clinical application fields, extending to new, non-perfusion applications of IVIM MRI, such as virtual MR elastography.
Author: Peter B. Barker
Publisher: Cambridge University Press
ISBN: 1107013399
Category : Medical
Languages : en
Pages : 373
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Book Description
This concise and comprehensive review uniquely contains all the information required to perform and interpret clinical MR perfusion imaging.
Author:
Publisher:
ISBN: 9789461825421
Category :
Languages : en
Pages : 235
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Book Description
Author: Jean Chen
Publisher: Humana
ISBN: 9781071617625
Category : Medical
Languages : en
Pages : 218
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Book Description
This volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.
Author: Donald W. McRobbie
Publisher: Cambridge University Press
ISBN: 1316688259
Category : Medical
Languages : en
Pages : 405
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Book Description
MR is a powerful modality. At its most advanced, it can be used not just to image anatomy and pathology, but to investigate organ function, to probe in vivo chemistry, and even to visualise the brain thinking. However, clinicians, technologists and scientists struggle with the study of the subject. The result is sometimes an obscurity of understanding, or a dilution of scientific truth, resulting in misconceptions. This is why MRI from Picture to Proton has achieved its reputation for practical clarity. MR is introduced as a tool, with coverage starting from the images, equipment and scanning protocols and traced back towards the underlying physics theory. With new content on quantitative MRI, MR safety, multi-band excitation, Dixon imaging, MR elastography and advanced pulse sequences, and with additional supportive materials available on the book's website, this new edition is completely revised and updated to reflect the best use of modern MR technology.
Author: William H. Theodore
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 312
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Book Description
Author: Nicole Seiberlich
Publisher: Academic Press
ISBN: 0128170581
Category : Computers
Languages : en
Pages : 1094
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Book Description
Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches
