Tissue Perfusion Quantification Using Magnetic Resonance Imaging and Contrast Media PDF Download
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Author: Jean-Paul Vallée
Publisher:
ISBN:
Category :
Languages : en
Pages : 250
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Book Description
Cette thèse décrit une approche originale de mesure de la perfusion tissulaire basée sur l'imagerie par résonance magnétique (IRM) et l'injection intraveineuse de produits de contraste. Les grands principes de la technique d'IRM ainsi que les différentes classes de produits de contraste sont passés en revue. Puis, les séquences d'impulsions RF utilisées pour la mesure de la perfusion tissulaire sont étudiées, suivies des méthodes de conversion du signal en concentration de produit de contraste. Enfin, la dernière partie présente deux classes de modèles permettant de mesurer la perfusion tissulaire à partir des courbes de transit obtenues avec l'IRM qui ont été développées durant cette thèse. La méthode proposée dans cette thèse démontre qu'il est possible de mesurer d'une manière non invasive par IRM le débit de perfusion tissulaire ainsi que cela a été vérifié dans quelques situations cliniques.
Author: Jean-Paul Vallée
Publisher:
ISBN:
Category :
Languages : en
Pages : 250
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Book Description
Cette thèse décrit une approche originale de mesure de la perfusion tissulaire basée sur l'imagerie par résonance magnétique (IRM) et l'injection intraveineuse de produits de contraste. Les grands principes de la technique d'IRM ainsi que les différentes classes de produits de contraste sont passés en revue. Puis, les séquences d'impulsions RF utilisées pour la mesure de la perfusion tissulaire sont étudiées, suivies des méthodes de conversion du signal en concentration de produit de contraste. Enfin, la dernière partie présente deux classes de modèles permettant de mesurer la perfusion tissulaire à partir des courbes de transit obtenues avec l'IRM qui ont été développées durant cette thèse. La méthode proposée dans cette thèse démontre qu'il est possible de mesurer d'une manière non invasive par IRM le débit de perfusion tissulaire ainsi que cela a été vérifié dans quelques situations cliniques.
Author: Farhood Saremi
Publisher: Lippincott Williams & Wilkins
ISBN: 1496318048
Category : Medical
Languages : en
Pages : 1810
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Book Description
Make optimal use of all the latest clinical applications of perfusion imaging! Perfusion Imaging is the first comprehensive resource that encompasses every facet of this important and rapidly advancing area of diagnostic imaging. Authored by an elite cadre of leading perfusion imaging authorities, this clinical reference offers balanced multimodality perspectives to deliver a well-rounded understanding of clinical issues and diagnoses, with a focus on practical clinical applications. In short, Perfusion Imaging provides the expert guidance you need to take advantage of the full capabilities of this powerful diagnostic tool.
Author: Bo Xu
Publisher:
ISBN:
Category :
Languages : en
Pages : 124
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Book Description
Magnetic resonance imaging (MRI) is a widely used non-invasive imaging technique, with rich contrast for interrogation of tissue physiology and pathology. MRI can be used to examine hemodynamic conditions like perfusion and oxygenation qualitatively and quantitatively. This dissertation reports new techniques that employ dynamic imaging and quantitative susceptibility mapping (QSM) to overcome technical challenges for improved MRI perfusion imaging and oxygenation quantification. Perfusion imaging after gadolinium contrast agent administration is a common clinical practice, where dynamic MRI technique is used to track contrast bolus. It is desirable to have high temporal resolution to capture blood dynamics, as well as high spatial resolution to depict small lesions. Unfortunately, these requirements are limited by hardware and physiological conditions. In this dissertation, a dynamic MRI technique was realized, using fast spiral acquisition and a constrained image reconstruction algorithm, to achieve high temporal-spatial resolution for liver perfusion imaging. Tissue susceptibility provides unique contrast in MRI. Recent development of QSM technique has been applied in various clinical applications. In this dissertation, the dynamic imaging method was extended to multi-echo acquisition and combined with QSM to map gadolinium contrast agent concentration during the first passage for cerebral perfusion mapping. Blood oxygenation is determined by the amount of deoxyhemoglobin in red blood cell. Magnetic susceptibility of deoxyhemoglobin is a source of MR contrast for imaging oxygenation. This dissertation reports correction schemes in both data acquisition and image reconstruction of QSM for improved blood oxygenation quantification.
Author: Nicole Seiberlich
Publisher: Academic Press
ISBN: 0128170581
Category : Computers
Languages : en
Pages : 1094
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Book Description
Quantitative Magnetic Resonance Imaging is a 'go-to' reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: - The basic physics behind tissue property mapping - How to implement basic pulse sequences for the quantitative measurement of tissue properties - The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* - The pros and cons for different approaches to mapping perfusion - The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor - maps and more complex representations of diffusion - How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed - How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance - Fingerprinting can be used to accelerate or improve tissue property mapping schemes - How tissue property mapping is used clinically in different organs - Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds - Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements - Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges - Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches
Author: Barry L. Zaret
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 704
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Book Description
This latest edition of NUCLEAR CARDIOLOGY provides up-to-the-minute information on current and future uses of radionuclides in imaging diagnosis of the heart. Thoroughly revised and updated, it contains practical information on radiopharmaceuticals, tracer kinetics, instrumentation, ventricular function, perfusion, acute ischemic syndrome, viability, and metabolic images, as well as a discussion of the role of nuclear cardiology in a changing health care system. Practitioners in nuclear medicine, radiology, and cardiology will benefit from having current information on a wide range of topics in one focused reference. Provides highly detailed and comprehensive information in one convenient resource Includes more than 600 images and illustrations to aid comprehension Incorporates the knowledge of internationally recognized authors who are experts in the field Discusses a broad spectrum of nuclear cardiology applications to help you gain a better perspective on contemporary cardiac nuclear medicine
Author: Katherine L Wright
Publisher:
ISBN:
Category : Biomedical engineering
Languages : en
Pages : 187
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Book Description
Tissue perfusion is an important metric that can provide valuable information for disease diagnosis, treatment planning, and treatment follow-up. MRI can quantify perfusion both with and without Gd-based contrast agents, and can provide spatially-localized perfusion maps. However, these techniques are rarely used in the clinical environment. The works in this thesis focused on providing novel data acquisition and/or reconstruction techniques to overcome limitations in DCE MRI and ASL in order to provide clinically-viable perfusion exams.There are three main projects that will be described in this thesis. First, a simultaneous 3D magnetic resonance angiography and perfusion (MRAP) exam is proposed and is demonstrated in the distal lower extremities. Second, a 3D non-Cartesian parallel imaging method is described and used to achieve a low-dose, 3D, high spatiotemporal resolution renal DCE MRI exam that is acquired without breath-holding. Finally, a novel approach to ASL is proposed using the Magnetic Resonance Fingerprinting framework to simultaneously quantify perfusion, transit time, and tissue T1 in a single, efficient acquisition.
Author: Mrignayani Kotecha
Publisher: John Wiley & Sons
ISBN: 1119193354
Category : Technology & Engineering
Languages : en
Pages : 444
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Book Description
Magnetic Resonance Imaging in Tissue Engineering provides a unique overview of the field of non-invasive MRI assessment of tissue engineering and regenerative medicine Establish a dialogue between the tissue-engineering scientists and imaging experts and serves as a guide for tissue engineers and biomaterial developers alike Provides comprehensive details of magnetic resonance imaging (MRI) techniques used to assess a variety of engineered and regenerating tissues and organs Covers cell-based therapies, engineered cartilage, bone, meniscus, tendon, ligaments, cardiovascular, liver and bladder tissue engineering and regeneration assessed by MRI Includes a chapter on oxygen imaging method that predominantly is used for assessing hypoxia in solid tumors for improving radiation therapy but has the ability to provide information on design strategies and cellular viability in tissue engineering regenerative medicine
Author: Birgitte Helene Pedersen
Publisher:
ISBN:
Category :
Languages : en
Pages : 131
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Book Description
Author: Hai-Ling Margaret Cheng
Publisher: Elsevier
ISBN: 0323952100
Category : Science
Languages : en
Pages : 564
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Book Description
Quantitative Perfusion MRI: Techniques, Applications, and Practical Considerations, Volume 11 clearly and carefully explains the basic theory and MRI techniques for quantifying perfusion non-invasively in deep tissue, covering all aspects of perfusion imaging, from acquisition requirements to selection of contrast agents and appropriate pharmacokinetic models and for reliable quantification in different diseases and tissue types. Specifically, this book enables the reader to understand what microvascular functional parameters can be measured with perfusion MRI, learn the basic techniques to measure perfusion in different organs, apply the appropriate perfusion MRI technique to the organ of interest, and much more. This complete reference on quantitative perfusion MRI is highly suitable for both early and experienced researchers, graduate students and clinicians wishing to understand how quantitative perfusion MRI can apply to their application area of interest. - Provides a one-stop resource for students and early and experienced researchers on all aspects of quantitative perfusion MRI as written by experts in the field - Explains basic theory and MRI techniques - Presents a strong focus on the practical considerations that can make or break perfusion MRI - Includes applications in oncology, cardiology, neurology and body imaging
Author: Denis Le Bihan
Publisher: CRC Press
ISBN: 0429763484
Category : Medical
Languages : en
Pages : 651
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Book Description
Intravoxel incoherent motion (IVIM) refers to translational movements which within a given voxel and during the measurement time present a distribution of speeds in orientation and/or amplitude. The concept was introduced in 1986 together with the foundation of diffusion MRI because it had been realized that flow of blood in capillaries (perfusion) would mimic a diffusion process and impact diffusion MRI measurements. IVIM-based perfusion MRI, which does not require injection of any tracer or contrast agent, has been first investigated in the brain, but is now experiencing a remarkable revival for applications throughout the body, especially for oncologic applications, from diagnosis to treatment monitoring. This book addresses a number of highly topical aspects of the field from leading authorities, introducing the concepts behind IVIM MRI, outlining related methodological issues, and summarizing its current usage and potential for clinical applications. It also presents future research directions, both in terms of methodological development and clinical application fields, extending to new, non-perfusion applications of IVIM MRI, such as virtual MR elastography.
