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Author: Beat H. Walpoth
Publisher: Springer
ISBN: 9783030053352
Category : Science
Languages : en
Pages : 0
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Book Description
Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
Author: Beat H. Walpoth
Publisher: Springer
ISBN: 9783030053352
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
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Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Julian Chaudhuri
Publisher: Springer Science & Business Media
ISBN: 1402037414
Category : Medical
Languages : en
Pages : 373
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Book Description
For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.
Author: Anwarul Hasan
Publisher: John Wiley & Sons
ISBN: 3527338632
Category : Science
Languages : en
Pages : 762
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Book Description
A comprehensive overview of the latest achievements, trends, and the current state of the art of this important and rapidly expanding field. Clearly and logically structured, the first part of the book explores the fundamentals of tissue engineering, providing a separate chapter on each of the basic topics, including biomaterials stem cells, biosensors and bioreactors. The second part then follows a more applied approach, discussing various applications of tissue engineering, such as the replacement or repairing of skins, cartilages, livers and blood vessels, to trachea, lungs and cardiac tissues, to musculoskeletal tissue engineering used for bones and ligaments as well as pancreas, kidney and neural tissue engineering for the brain. The book concludes with a look at future technological advances. An invaluable reading for entrants to the field in biomedical engineering as well as expert researchers and developers in industry.
Author: TJ Bunt
Publisher: Wiley-Blackwell
ISBN: 9780879935764
Category : Medical
Languages : en
Pages : 420
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Book Description
Vascular graft infection is a complex and challenging problem for the vascular surgeon. Despite significant advances that have been made in managing patient problems associated with graft infection during the last 25 years, the topic of vascular graft infection has been only loosely covered in various textbooks. Fortunately, this monograph fills this void of information by offering a wealth of useful, clearly organized clinical knowledge
Author: Gerhard Ziemer
Publisher: Springer
ISBN: 3662526727
Category : Medical
Languages : en
Pages : 1152
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Book Description
This text describes and illustrates with some 700 detailed anatomic and surgical drawings the whole spectrum of surgical procedures employed to treat acquired and congenital diseases of the heart and great vessels in adults and children. A rather traditional chapter on history of cardiac surgery precedes chapters dedicated to quality improvement, followed by ICU management in adult and pediatric cardiac surgery, and techniques of extracorporeal circulation in both age groups. Further special topics are cardiovascular tissue engineering, minimally invasive cardiac surgery, endovascular treatment of aortic diseases, and cardiac assist devices, including total artificial heart. Written by 71 internationally recognized experts from 40 cardiac units in Central Europe and North America, this book will be invaluable not only for both novice and experienced surgeons, but also for all physicians, nurses, and technicians caring for patients with heart disease of any type, at any age.
Author: Feng Zhao
Publisher: Humana
ISBN: 9781071617076
Category : Science
Languages : en
Pages : 262
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Book Description
This volume explores the latest techniques used to study the field of tissue engineered vascular grafts (TEVGs). The chapters in this book cover a wide array of topics such as deriving vascular cells from monocytes and induced pluripotent stem cells; engineering vascular grafts using various biomaterials and stem cells, stem cell-derived, or primary vascular cells; biomaterial modification by anticoagulation molecules; vascular bioengineering technologies such as 3D bioprinting; and fabrication of TEVGs with different geometry and multiphase structures. This book also features protocols for grafting and evaluation of vascular grafts in animal models, vascular imaging in animals, and the quantification of blood vessel permeability. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vascular Tissue Engineering: Methods and Protocols is a valuable resource for biomedical engineers, cell biologists, vascular surgeons, doctors, and nurses.
Author: The National Academies
Publisher: National Academies Press
ISBN: 0309104661
Category : Medical
Languages : en
Pages : 140
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Book Description
The 2006 conference, "Smart Prosthetics: Exploring Assistive Devices for the Body and Mind," attracted scientists, engineers and medical researchers to participate in a series of task groups to develop research plans to address various challenges within the prosthetics field. Eleven conference task groups gave the participants eight hours to develop new research approaches to various challenges, including: build a smart prosthesis that will grow with a child; develop a smart prosthetic that can learn better and/or faster; refine technologies to create active orthotic devices; and describe a framework for replacing damaged cortical tissue and fostering circuit integration to restore neurological function. Representatives from public and private funding organizations, government, industry, and the science media also participated in the task groups. This book provides a summary of the conference task groups. For more information about the conference, visit the Smart Prosthetics conference site. The National Academies Keck Futures Initiative was launched in 2003 to stimulate new modes of scientific inquiry and break down the conceptual and institutional barriers to interdisciplinary research. The National Academies and the W.M. Keck Foundation believe considerable scientific progress and social benefit will be achieved by providing a counterbalance to the tendency to isolate research within academic fields. The Futures Initiative is designed to enable researchers from different disciplines to focus on new questions upon which they can base entirely new research, and to encourage better communication between scientists as well as between the scientific community and the public. Funded by a $40 million grant from the W.M. Keck Foundation, the National Academies Keck Futures Initiative is a 15-year effort to catalyze interdisciplinary inquiry and to enhance communication among researchers, funding agencies, universities, and the general public with the object of stimulating interdisciplinary research at the most exciting frontiers. The Futures Initiative builds on three pillars of vital and sustained research: interdisciplinary encounters that counterbalance specialization and isolation; the identification and exploration of new research topics; and communication that bridges languages, cultures, habits of thought, and institutions. Toward these goals, the National Academies Keck Futures Initiative incorporates three core activities each year: Futures conferences, Futures grants, and National Academies Communication Awards. For more information about the Initiative, visit www.keckfutures.org.
Author: James Chang
Publisher: World Scientific
ISBN: 9814464600
Category : Medical
Languages : en
Pages : 284
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Book Description
Musculoskeletal applications of tissue engineering will be among the first to achieve widespread clinical use, and the resulting shift in clinical and surgical paradigms will highlight the need for an authoritative text on tissue engineering for musculoskeletal tissues including nerve, bone, tendon, skin, vessels, and cartilage. This book will serve the needs of a large readership including plastic surgeons, orthopedic surgeons, medical residents and medical students, researchers and academic faculty in regenerative medicine and biomedical engineering, and medical device experts. This textbook will serve as the curriculum for undergraduate and graduate courses in biomedical engineering and surgery.Notable contributors to this volume include Antonios G Mikos, PhD; Wei Liu, MD; Yilin Cao, MD; Mark Randolph, MAS; Jennifer Elisseeff, PhD; Geoffrey C Gurtner, MD; Michael T Longaker, MD; and James Chang, MD, all of whom are leaders in tissue engineering research and applications.
Author: Insup Noh
Publisher: Springer
ISBN: 9811304459
Category : Medical
Languages : en
Pages : 389
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Book Description
This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.
