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Author: Frantz Funck-Brentano
Publisher:
ISBN:
Category : France
Languages : en
Pages : 576
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Author: Frantz Funck-Brentano
Publisher:
ISBN:
Category : France
Languages : en
Pages : 576
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Book Description
Author: Karyn M. Frick
Publisher:
ISBN: 0190645903
Category : Medical
Languages : en
Pages : 525
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Book Description
"A book about the influence of estrogens on memory would have been unthinkable as recently as 30 years ago. Although a few small studies in the late 1970's reported a beneficial effect of estrogens on memory in human women (Hackman and Galbraith, 1976; Fedor-Freybergh, 1977), examination of the role of estrogens in memory did not truly capture more widespread attention until the pioneering work of Barbara Sherwin and colleagues in 1988 and beyond. In her initial paper, Sherwin showed that bilateral removal of the ovaries (aka surgical menopause) led to impaired short-term and long-term memory, whereas treatment of surgically menopausal women with estradiol alone, testosterone alone, or estradiol plus testosterone prevented this decline (Sherwin, 1988). As a search for the terms "estrogen" and "memory" in PubMed illustrates, well over 2000 papers have been published on the subject of estrogens and memory in the ensuing decades. The vast majority of these studies have focused on the hippocampus, a bilateral medial temporal lobe structure essential for the formation of episodic memories, particularly those with spatial, contextual, relational, temporal, and recognition components (Olton et al., 1979; Morris et al., 1982; Kim and Fanselow, 1992; Squire, 1992; Cohen and Stackman, 2015; Tonegawa et al., 2015; Eichenbaum, 2017). Although various forms of learning and memory are mediated by numerous brain regions, including the prefrontal cortex, medial temporal lobe cortices, amygdala, striatum, and cerebellum, the hippocampus has received the lion's share of attention due to its central importance for episodic memory formation. Hippocampal damage produces profound retrograde amnesia for facts and events, as well as anterograde amnesia for new information and impairments in spatial navigation (Winocur, 1990; Anagnostaras et al., 2001; Clark et al., 2002; Gilboa et al., 2006). Hippocampal dysfunction in middle-aged and aged subjects is a primary contributor to age-related memory decline (Golumb et al., 1996; Grady et al., 2003; Apostolova et al., 2010; Burke and Barnes, 2010; Small et al., 2011; Yassa et al., 2011), and has also been implicated in the cognitive impairments observed in diseases such as schizophrenia and depression (Small et al., 2011; Nakahara et al., 2018; Santos et al., 2018; Ott et al., 2019). Moreover, the hippocampi of patients with Alzheimer's disease are substantially atrophied and burdened with copious amounts of amyloid plaques and neurofibrillary tangles, the hallmark pathologies of this insidious disease (Hyman et al., 1984; Walsh and Selkoe, 2004; Selkoe and Hardy, 2016). As such, understanding how estrogens influence hippocampal functioning may provide important insights not only about the fundamental neurobiology of memory processes, but also into the etiology of neuropsychiatric and neurodegenerative diseases"--
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 824
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 844
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Author:
Publisher:
ISBN:
Category : Irrigation
Languages : en
Pages : 576
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Author: Hervé Guibert
Publisher:
ISBN: 9781943679140
Category :
Languages : en
Pages :
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"Arthur's Whims" is the tale of "a modern saint," a love story born of a childhood dream of being "alone on a boat with a boy, a friend." Arthur and his beloved Bichon-a young man who, after drinking Arthur's tears, becomes pregnant with his child-drift through a stream of identities and circumstances: birdcatchers for a French taxidermist; sailors shipwrecked in an ice fortress; explorers of the Isles of Traitors, Babies, and Sadness; famous magicians in Oklahoma; religious and medical marvels. It is an anarchic, outrageous novel, in the tradition of Edgar Allan Poe and Comte de Lautréamont, now available in English for the first time in translation by Daniel Lupo. This edition includes Hervé Guibert's essay "The Bear," in which he compares his books to rooms in a house, writing: "Arthur's Whims would be the library of the house, and the bedroom of a child who will never be." It is "a true adventure novel in the tradition of the genre, or what I believed to be its tradition, with great journeys, disasters, shipwrecks, cataclysms."
Author:
Publisher:
ISBN:
Category : Automobile industry and trade
Languages : en
Pages : 846
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Author: John Henry Wilbrandt Stuckenberg
Publisher:
ISBN:
Category : Church
Languages : en
Pages : 380
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Author: Michael J. Boyle
Publisher:
ISBN: 019063586X
Category : History
Languages : en
Pages : 401
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Book Description
Over the last decade, the rapid pace of innovation with drone technology has led to dozens of new and innovative commercial and scientific applications, from Amazon drone deliveries to the patrolling of national parks with drones. But what is less understood is how the spread of unmanned technology will change the patterns of war and peace in the future. Will the use of drones produce a more stable world or will it lead to more conflict? Will drones gradually replace humans on the battlefield or will they empower soldiers to act more precisely, and humanely, in crisis situations? How will drones change surveillance around the world and at home? The Drone Age traces the rise of unmanned technology and how it is reshaping our world. The spread of drones is reordering geopolitical fault lines and providing new ways for states to test the nerves and strategic commitments of their rivals. Drones are also allowing terrorist groups like the Islamic State to take to the skies and to level the playing field against their enemies. Across the world, the low financial cost of drones and the reduced risks faced by pilots is making drone technology an essential tool for militaries, peacekeeping forces and even private companies. From large surveillance drones to insect-like micro-drones, unmanned technology is revolutionizing the way that states and non-state actors compete with each other and is providing game-changing benefits to those who can most rapidly adapt unmanned technology to their own purposes. Yet peacekeeping and humanitarian organizations are also utilizing drones too. An essential guide to a surprisingly complex disruptive force in world politics, The Drone Age shows how the mastery of drone technology will become central to the ways that governments and non-state actors seek power and influence in the coming decades.
Author: Eric Cheyfitz
Publisher: Routledge
ISBN: 1351839071
Category : History
Languages : en
Pages : 418
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Book Description
The Disinformation Age, beginning in the present and going back to the American colonial period, constructs an original historical explanation for the current political crisis and the reasons the two major political parties cannot address it effectively. Commentators inside and outside academia have described this crisis with various terms — income inequality, the disappearance of the middle-class, the collapse of the two-party system, and the emergence of a corporate oligarchy. While this book uses such terminology, it uniquely provides a unifying explanation for the current state of the union by analyzing the seismic rupture of political rhetoric from political reality used within discussion of these issues. In advancing this analysis, the book provides a term for this rupture, Disinformation, which it defines not as planned propaganda but as the inevitable failure of the language of American Exceptionalism to correspond to actual history, even as the two major political parties continue to deploy this language. Further, in its final chapter this book provides a way out of this political cul-de-sac, what it terms "the limits of capitalism’s imagination," by "thinking from a different place" that is located in the theory and practice of the Indigenous peoples of the Americas.
