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Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 78
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Book Description
WHEN VARIANT SQUAD Captain Joe Borland works up the nerve to take care of some long-overdue business, he stumbles upon the terrifying shape of things to come. Dreams and reality collide in the shadow of the Variant Effect. Joe Borland returns in PAINKILLER, a gut-wrenching novella of grisly horror that takes place between the events in The Variant Effect books: SKIN EATERS and GREENMOURNING. It's been twenty years since Borland battled the Variant Effect, and twenty since he let his partner get skinned alive. Now both of them are being ordered back into action to meet the new threat.
Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 78
Get Book Here
Book Description
WHEN VARIANT SQUAD Captain Joe Borland works up the nerve to take care of some long-overdue business, he stumbles upon the terrifying shape of things to come. Dreams and reality collide in the shadow of the Variant Effect. Joe Borland returns in PAINKILLER, a gut-wrenching novella of grisly horror that takes place between the events in The Variant Effect books: SKIN EATERS and GREENMOURNING. It's been twenty years since Borland battled the Variant Effect, and twenty since he let his partner get skinned alive. Now both of them are being ordered back into action to meet the new threat.
Author: Jeffrey Steven Mogil
Publisher: Progress in Pain Research and
ISBN:
Category : Medical
Languages : en
Pages : 376
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Book Description
Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Author: Gérard Mick
Publisher: Springer
ISBN: 9783319374543
Category : Medical
Languages : en
Pages : 0
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Book Description
Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.
Author: Jurgen Brockmoller
Publisher: Frontiers Media SA
ISBN: 2889740293
Category : Science
Languages : en
Pages : 145
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Book Description
Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient. Apparently, the lack of OCT1 do not lead to apparent substantial pathological changes in these individuals. It thus appears that this transporter is not essential to human life, but does it means that OCT1 is irrelevant? In the last 25 years since the first cloning of this transporter, data on its pharmacological and physiological relevance is steadily accumulating. Numerous clinically relevant drugs (e.g. metformin, morphine, fenoterol, sumatriptan, tramadol and tropisetron) have been shown to be substrates of OCT1, and OCT1 deficiency has been shown to affect the pharmacokinetics, efficacy, or toxicity of these drugs. Also vitamin B1 has been shown to be a substrate of OCT1, and in genetically modified mice OCT1 substantially modulated hepatic lipid metabolism, total body fat and systemic glucose and lipid concentrations. Still, numerous important questions remain unsolved: For which drugs, toxins, or other endogenous or exogenous substances is OCT1 relevant? How can we predict the relevance of OCT1 from in vitro studies? What determines the substrate selectivity of OCT1 in comparison to other transporters or transport processes for organic cations? What regulates the expression of OCT1 in the liver and possibly in other tissues? What is the impact of OCT1 variation in different areas of medicine, including the therapies for cancer as well as for pulmonary, cardiovascular, or neurological diseases? How can evolutionary biology contribute to a better understanding of the roles of OCT1? And, importantly, what types of research are likely to significantly further the knowledge on OCT1 in the next decades?
Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 622
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Book Description
NATHAN CHAMBERS and his bride-to-be want to rekindle their romance after they were forced to cancel their wedding at the start of the pandemic, and the stressful lockdown that followed left the relationship on rocky ground. Nate hopes some quality time at the treasured family cottage will help them put things right. The young couple arrives with nature promising blue skies despite the looming storm clouds, but they quickly realize that rain will be the least of their worries. Something weird is happening on the lake. The locals are distant, the animal life is scattered or missing, and Nate senses a threatening presence in the trees. When a mysterious group moves into the abandoned cottage on the lot beside theirs, a neighbor’s death soon after raises the specter of the pandemic’s return, though the truth is more horrifying—even if it sounds insane. The strangers next door are a dangerous breed, but they’ve been followed to the lake by something worse. A time of reckoning has come, and blood will mark a return of the Kind that first terrified in BENT STEEPLE.
Author: Raymond S. Sinatra
Publisher: Cambridge University Press
ISBN: 1139491989
Category : Medical
Languages : en
Pages : 551
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Book Description
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Author: Raymond S. Sinatra
Publisher: Cambridge University Press
ISBN: 0521874912
Category : Medical
Languages : en
Pages : 729
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Book Description
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author: G. Wells Taylor
Publisher: G. Wells Taylor
ISBN:
Category : Fiction
Languages : en
Pages : 132
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Book Description
"THAT ANIMAN robot sure is a monster! Of course, in my own special way, so am I," said Thirteen-Time World Champion Snuff Fighter, NUKE. Is he the explosive and dangerous result of illegal genetic experiments gone wrong or a Darwinian throwback spawned by radioactive toxins, viral outbreaks, and climate change? YOU ASK HIM! Join the world's most violent man on a raunchy voyage of self-discovery that takes him from the frigid peaks of the Canadian Rockies to the blistering, blood-soaked Snuff Fighting rings of Argentina. Professional fighting goes full gladiator in this savagely funny and terrifying story of the very near future. THE SOLDIER, Book One of G. Wells Taylor’s 21st Century Snuff Fighter epic, will leave you screaming for more!
Author: Timothy R Deer
Publisher: Springer Science & Business Media
ISBN: 1461415608
Category : Medical
Languages : en
Pages : 1084
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Book Description
Edited by master clinician-experts appointed by the American Academy of Pain Medicine, this is a state-of-the-art multidisciplinary textbook covering medical, interventional, and integrative approaches to the treatment and management of pain. It is designed as a practical and comprehensive primary reference for busy physicians and is also an up-to-date resource for preparing for certification examinations in pain medicine. · Written and edited by world-class authorities · “Key Points” preview contents of each chapter · Leading edge medical topics, such as monitoring opioid use and abuse, and the emerging role of cannabinoids in pain treatment · Expert guidance on full range of interventional techniques · Clinical anatomy and physiology for the interventionist · Behavioral dimensions of the experience and management of pain · Integrative approaches for treating the “whole person” · Legal issues, such as failure to treat pain · First-hand patient accounts
Author:
Publisher: Academic Press
ISBN: 0128140712
Category : Medical
Languages : en
Pages : 250
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Book Description
Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. - Compiles all known information on epigenetic regulation of chronic pain in one volume - Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics - Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth - Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain
