The Synthesis of Substituted Quinolizidines PDF Download
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Author: Michael Roger Dick
Publisher:
ISBN:
Category :
Languages : en
Pages : 342
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Author: Michael Roger Dick
Publisher:
ISBN:
Category :
Languages : en
Pages : 342
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Author: Vladislav Semak
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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![Part I: Synthesis and Stereochemistry of Some 3-substituted Quinolizidines Related to Biologically Active Phenethylamines ; Part II: Synthesis and Stereochemistry of Some 6-phenyl-6-propionoxyperhydrobenzo[c]quinolizines as Potential Analgetics PDF](https://books.google.com/books/content/images/frontcover/T_z3tgAACAAJ?fife=w80-h100)
Author: Michael Eugene Rogers
Publisher:
ISBN:
Category :
Languages : en
Pages : 306
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Author: Jimmy R. Daniel
Publisher:
ISBN:
Category :
Languages : en
Pages : 260
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Author: Gidget C. Tay
Publisher:
ISBN: 9781321847307
Category :
Languages : en
Pages : 288
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A modular synthesis of the reportedly potent molluscicide, cyanolide A, was developed to provide facile access to a series of cyanolide A analogues. The synthesis of strategic derivatives was initiated in order to determine the structural features of cyanolide A required for molluscicidal activity. Cyanolide A was synthesized in twelve steps with an overall 2% yield. After extensive SAR studies, it was found that cyanolide A was not responsible for the reported molluscicidal activity observed in the original studies. A diastereoselective synthesis of cis-2,6-disubstituted tetrahydropyran-4-ones was developed. The key step of this methodology, a silyl enol ether Prins cyclization, was promoted by a condensation reaction between a hydroxy silyl enol ether and an aldehyde to afford substituted tetrahydropyran-4-ones. The cyclization was tolerant of many functional groups, and the modular synthesis of the hydroxy silyl enol ether allowed for the formation of more than thirty new tetrahydropyran-4-ones with up to 97% yield and >95:5 dr. The cyclization step forms new carbon-carbon and carbon-oxygen bonds, as well as a quaternary center with good diastereoselectivity. The method provides a versatile route for the synthesis of substituted tetrahydropyrans. The scope and diastereoselectivity of an intramolecular aza-Diels-Alder reaction starting from a variety of 2-cyano-1-aza-1,3-butadienes was explored. The key reactions involved in synthesizing the Diels-Alder precursors are an imine condensation and a Strecker reaction and subsequent oxidation. The method provides a route for the synthesis of substituted quinolizidine and indolizidine heterocycles containing a cyanoenamine functional group. A visual aid teaching tool, the DanceChemistry video series, has been developed to teach fundamental chemistry concepts through dance. These educational videos portray chemical interactions at the molecular level using dancers to represent chemical species. Students reported that the DanceChemistry videos helped them visualize chemistry ideas in a new and memorable way. Surveying the general laboratory course at the University of California, Irvine (n = 1266), 75% of the students said they wanted to use these videos to learn additional chemistry topics in the future. Data from pre- and post-surveys show an increase in students' average scores after watching a five minute DanceChemistry video. These instructional videos are disseminated broadly through a dedicated YouTube channel, DanceChemistry.
![Chapter I, The Synthesis, Conformational Analysis and Catalytic Properties of Four Chiral (non-racemic) 4-substituted Quinolizidines ; Chapter II, Alkylation Reactions of Derivatives of the Camphor Imine of T-butylglycine [microform] PDF](https://books.google.com/books/content/images/frontcover/8gT6wQEACAAJ?fife=w80-h100)
Author: Luca Carmine Matassa
Publisher: National Library of Canada
ISBN: 9780315505209
Category :
Languages : en
Pages : 304
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Author: Hui Li
Publisher:
ISBN:
Category :
Languages : en
Pages : 1196
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I. (3 + 2) Cycloaddition reactions of oxyallyl cationic intermediates with indoles Cyclopenta-and cyclohexa[b]indolines are ubiquitous molecular skeletons in natural products and pharmaceutical agents. We have developed (3 +2) cycloaddition reactions of 3-substituted indoles with [alpha]-haloketones to access those scaffolds. Significant diastereo-and regiochemical control were observed. The reactions were found to proceed via an O-bound intermediate. Kinetic studies of the cycloaddition reactions and DFT calculations (B3LYP-D3/6-311++G**/MeOH) on cyclization mechanisms involving the 2-hydroxyallyl cation and its deprotonated oxyallyl cation have been performed. Both oxyallyl cationic intermediates were predicted to be viable reactive species. The synthetic potential of these reactions were demonstrated in the concise syntheses of structural cores of vincorine, isocorymine, and aspidophylline A. II. Vinylogous Mukaiyama-Michael reactions of Dihydropyridinones 2,3-Dihydro-4-pyridinones are versatile building blocks in constructing nitrogen-containing heterocyclic compounds. We have developed In(III)-catalyzed vinylogous Mukaiyama-Michael (vM-Michael) addition of O-silyl vinylketene acetals to dihydropyridinones. The reactions featured the employment of supersilyl groups to control the [alpha]-vs-[gamma] regioselectivity when [gamma]-substituted O-silyl vinylketene acetals were used. These transformations can allow easy access to quinolizidine-based alkaloids. This potential was demonstrated by formal synthesis of deoxynupharidine, lasubine I and II, as well as construction of the structural core of hupermine A. III. Discovery of the first known apoptotic monomeric nuphar analogs and enantioselective formal syntheses of 11 nuphar alkaloids (+)-6-Hydroxythiobinupharidine induces apoptosis of U937 human leukemia cells in a speed faster than any known small organic molecules. In order to obtain useful SAR information, we have designed and synthesized a stereochemically diverse collection of monomeric nuphar analogs bearing C6 hemiaminal hydroxyl groups. We have also achieved the concise enantioselective formal syntheses of eight dimeric and three monomeric nuphar alkaloids. The above syntheses involved the development of highly enantioselective chiral phosphoric acid-catalyzed vinylogous Mukaiyama-Mannich (vM-Mannich) reactions. The vM-Mannich reactions employed the supersilyl groups as a key element in controlling regio-, enantio- and diastereoselectivity. Biological evaluation of the monomeric nuphar quinolizidines identified analogs that are even more potent than the parent natural product (+)-6-Hydroxythiobinupharidine.
Author: Kevin Matthew Maloney
Publisher:
ISBN:
Category :
Languages : en
Pages : 532
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Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular Diels-Alder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts are versatile synthetic intermediates which can be further elaborated by stereoselective alkylation, reduction, reductive cyclization, and Bruylants reactions. The first part of this thesis describes the full details of our studies on the synthesis of iminoacetonitriles, the scope of their Diels-Alder reactions, and the synthetic elaboration of the a-amino nitrile cycloadducts to provide access to a variety of substituted quinolizidine and indolizidine derivatives. The second part of this thesis reports on the total synthesis of quinolizidine ( - )-217A and our efforts directed toward the total synthesis of indolizidine ( - )-235B'.
Author: Saleem Syed Sultan
Publisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 310
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Author: Charles G. McCarty
Publisher:
ISBN:
Category :
Languages : en
Pages : 54
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