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Author: Yves Pichon
Publisher: Xlibris Corporation
ISBN: 1479793701
Category : Biography & Autobiography
Languages : en
Pages : 101
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Book Description
The sodium theory revisited (45 years of a full time CNRS neurophysiologist). The sodium theory has been elegantly proposed by Hodkin, Huxley and Katz in the early fifties, after their experiments on Plymouth squids, to account for the role of sodium and potassium ions in nerve activity. Since then, the electrophysiological techniques and the data acquisition techniques have known an amazing development. In this short paper, Yves Pichon wants to give an account of what happened since then in different laboratories (mostly marine) with a variety invertebrate species and mostly insects. One of the most important technical development has been the use of single cockroach axons which have been found to behave very much like squid axons. Another, almost simultaneous development which revealed extremely useful for the understanding of the nerve function was "in situ" microelectrode recording which enables an indirect analysis of the extraaxonal environement. Experiments on several species indicate that the CNS is protected from the ionic environment by a blood-brain barrier. On the other hand, quite unexpectedly, little ion accumation is detected in the vicinity of the axonal membrane in physiological conditions. Another innovating technique was the 'patch-clamp' technique which enables the recording of the activity of individual ionic channels in cultured neurones. The last chapter of this report is devoted to different mechansims leading to repetitive activity through modificatrion of the sodium and potassium axonal conductances.
Author: Yves Pichon
Publisher: Xlibris Corporation
ISBN: 1479793701
Category : Biography & Autobiography
Languages : en
Pages : 101
Get Book Here
Book Description
The sodium theory revisited (45 years of a full time CNRS neurophysiologist). The sodium theory has been elegantly proposed by Hodkin, Huxley and Katz in the early fifties, after their experiments on Plymouth squids, to account for the role of sodium and potassium ions in nerve activity. Since then, the electrophysiological techniques and the data acquisition techniques have known an amazing development. In this short paper, Yves Pichon wants to give an account of what happened since then in different laboratories (mostly marine) with a variety invertebrate species and mostly insects. One of the most important technical development has been the use of single cockroach axons which have been found to behave very much like squid axons. Another, almost simultaneous development which revealed extremely useful for the understanding of the nerve function was "in situ" microelectrode recording which enables an indirect analysis of the extraaxonal environement. Experiments on several species indicate that the CNS is protected from the ionic environment by a blood-brain barrier. On the other hand, quite unexpectedly, little ion accumation is detected in the vicinity of the axonal membrane in physiological conditions. Another innovating technique was the 'patch-clamp' technique which enables the recording of the activity of individual ionic channels in cultured neurones. The last chapter of this report is devoted to different mechansims leading to repetitive activity through modificatrion of the sodium and potassium axonal conductances.
Author: A. Stoyanov
Publisher: Elsevier
ISBN: 0080518966
Category : Science
Languages : en
Pages : 411
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Book Description
The book deals with the theory and practice of all electrophoretic steps leading to proteome analysis, i.e. isoelectric focusing (including immobilized pH gradients), sodium dodecyl sulphate electrophoresis (SADS-PAGE) and finally two-dimensional maps. It is a reasoned collection of all modern, relevant, up-to-date methodologies leading to successful fractionation, analysis and characterization of every polypeptide spot in 2-D map analysis. It includes chapters on the most sophisticated mass spectrometry developments and it helps the reader in navigating through the most important databases in proteome analysis, including step by step tours in selected sites. Yet, this book's unique strength and feature is the fact that it combines not only practice (in common with any other book on this topic) but also theory, by giving a detailed treatment on the most advanced theoretical treatments of steady-state techniques, such as isoelectric focusing and immobilized pH gradients. A lot of this theory is newly developed and presented to the public for the first time. Thus, this book should satisfy not only the needs of every day practitioners, but also the desires of the most advanced theoreticians in the field, who will surely appreciate the novel theories presented here. Also the methodological section contains several as yet unpublished protocols, correcting some of the existing ones and showing the pitfall and limitations of even well ingrained protocols in proteome analysis, which are here critically re-evaluated for the first time.
Author: Thomas M. McKenna
Publisher: Academic Press
ISBN: 1483296067
Category : Computers
Languages : en
Pages : 663
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Book Description
This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs.The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods.
Author: Alessandro Capucci
Publisher: Springer
ISBN: 3319916777
Category : Medical
Languages : en
Pages : 205
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Book Description
This book elucidates a number of new concepts on P-wave evaluation and QRS depolarization properties, and reports on several repolarization findings never covered in previous ECG books. The content is primarily based on case reports, some of which are compared in order to reveal their ostensibly small but significant differences. The book addresses a significant and lingering gap in ECG interpretation, which is the actual cause of many poor decisions in the diagnostic and therapeutic contexts. Further, the book has an interdisciplinary appeal, and will be of equal interest to professionals and scholars with an interest in cardiology and ECG interpretation.
Author: Vic Morris
Publisher: Elsevier
ISBN: 0857098896
Category : Technology & Engineering
Languages : en
Pages : 481
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Book Description
The development of high-quality foods with desirable properties for both consumers and the food industry requires a comprehensive understanding of food systems and the control and rational design of food microstructures. Food microstructures reviews best practice and new developments in the determination of food microstructure.After a general introduction, chapters in part one review the principles and applications of various spectroscopy, tomography and microscopy techniques for revealing food microstructure, including nuclear magnetic resonance (NMR) methods, environmental scanning electron, probe, photonic force, acoustic, light, confocal and infrared microscopies. Part two explores the measurement, analysis and modelling of food microstructures. Chapters focus on rheology, tribology and methods for modelling and simulating the molecular, cellular and granular microstructure of foods, and for developing relationships between microstructure and mechanical and rheological properties of food structures. The book concludes with a useful case study on electron microscopy.Written by leading professionals and academics in the field, Food microstructures is an essential reference work for researchers and professionals in the processed foods and nutraceutical industries concerned with complex structures, the delivery and controlled release of nutrients, and the generation of improved foods. The book will also be of value to academics working in food science and the emerging field of soft matter. - Reviews best practice and essential developments in food microstructure microscopy and modelling - Discusses the principles and applications of various microscopy techniques used to discover food microstructure - Explores the measurement, analysis and modelling of food microstructures
Author: David H. Alpers
Publisher: Lippincott Williams & Wilkins
ISBN: 1496310004
Category : Medical
Languages : en
Pages : 677
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Book Description
Meant for quick retrieval of vital information regarding the management of nutritional issues in patients with gastroenterological problems--either primary or as the consequence of other medical disorders, such as diabetes, hyperlipidemia and obesity. The book addresses normal physiology and pathophysiology, and offers chapters on diseases that can lead to specific nutritional problems. The clinical focus is on therapeutic nutrition and dietary management.
Author: Jay Schulkin
Publisher: JHU Press
ISBN: 1421429373
Category : Psychology
Languages : en
Pages : 208
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Book Description
In the first half of the twentieth century, psychology was a discipline in search of scientific legitimacy. Debates raged over how much of human and animal behavior is instinctive and how much is learned, and how behavior could be quantified accurately. At the Johns Hopkins University's new Phipps Psychiatric Clinic, Curt P. Richter stood aside from these heated theoretical arguments, choosing instead to apply his data-collection methods, innovative measurement techniques, playful sense of exploration, and consummate surgical skill to laboratory examinations of the biological basis of behavior. From identifying the biological clocks that govern behavior and physiology to observing the self-regulation of nutrient levels by the body, the cyclical nature of some mental illnesses, and the causes of hopelessness, Richter's wide-ranging discoveries not only influenced the burgeoning field of psychobiology and paved the way for later researchers but also often had implications for the treatment of patients in the clinic. At the time of his death in 1988, Richter left behind a massive collection of laboratory data. For this book, Jay Schulkin mined six decades of Richter's archived research data, personal documents, and interviews to flesh out an engaging portrait of a "laboratory artisan" in the context of his work.
Author: Elke Meissner
Publisher: Springer Nature
ISBN: 3030563057
Category : Technology & Engineering
Languages : en
Pages : 351
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Book Description
This book provides a collection of contributed chapters, delivering a comprehensive overview of topics related to the synthesis and crystal growth of nitride compounds under supercritical ammonia conditions. Focusing on key chemical and technological aspects of ammonothermal synthesis and growth of functional nitride compounds, the book also describes many innovative techniques for in-situ observation and presents new data fundamental for materials synthesis under ammonothermal conditions. With its detailed coverage of many thermodynamic and kinetics aspects, which are necessary for understanding and controlling crystal growth, this contributed volume is the ideal companion to materials chemists and engineers at any point in their journey in this rich and exciting field.
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Publisher:
ISBN:
Category : Nuclear energy
Languages : en
Pages : 794
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Book Description
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Category : Aeronautics
Languages : en
Pages : 702
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