The Role of the Mitochondria in Neural Degeneration PDF Download
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Author: Xin Qi
Publisher: Academic Press
ISBN: 9780443217579
Category : Science
Languages : en
Pages : 0
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Book Description
The Role of the Mitochondria in Neural Degeneration examines the significance of mitochondria and their impairment in the development of neurodegenerative conditions. The book opens with an introduction to mitochondria and their significance in neuronal function before exploring the cause and effect of mitochondrial impairment. Chapters cover a range of aspects including mitochondrial dynamics in neurodegenerative diseases, mitophagy and autophagy in neuronal degeneration, and mtDNA integrity. Intercellular connection damage and the effect this can have on cellular function is also investigated. Finally the book closes with a section on therapeutic interventions for targeting mitochondria in the treatment of human diseases. This is a volume in Elsevier’s new series Hot Topics in Physiology, published in association with the International Union of Physiological Sciences (IUPS). It is an ideal reference for cell biologists, investigators in mitochondrial biology, and researchers working with neurodegenerative diseases.
Author: Xin Qi
Publisher: Academic Press
ISBN: 9780443217579
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
The Role of the Mitochondria in Neural Degeneration examines the significance of mitochondria and their impairment in the development of neurodegenerative conditions. The book opens with an introduction to mitochondria and their significance in neuronal function before exploring the cause and effect of mitochondrial impairment. Chapters cover a range of aspects including mitochondrial dynamics in neurodegenerative diseases, mitophagy and autophagy in neuronal degeneration, and mtDNA integrity. Intercellular connection damage and the effect this can have on cellular function is also investigated. Finally the book closes with a section on therapeutic interventions for targeting mitochondria in the treatment of human diseases. This is a volume in Elsevier’s new series Hot Topics in Physiology, published in association with the International Union of Physiological Sciences (IUPS). It is an ideal reference for cell biologists, investigators in mitochondrial biology, and researchers working with neurodegenerative diseases.
Author: Lawrence H. Lash
Publisher: Elsevier
ISBN: 1483218619
Category : Science
Languages : en
Pages : 527
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Book Description
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author: Stavros Baloyannis
Publisher: BoD – Books on Demand
ISBN: 1789855314
Category : Medical
Languages : en
Pages : 125
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Book Description
The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders.
Author: Amy K. Reeve
Publisher: Springer
ISBN: 3319286374
Category : Medical
Languages : en
Pages : 379
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Book Description
This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.
Author: Bingwei Lu
Publisher: Springer Science & Business Media
ISBN: 940071291X
Category : Medical
Languages : en
Pages : 271
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Book Description
Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Author: A. E. Harding
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 284
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Book Description
Author: Roberto Scatena
Publisher: Springer Science & Business Media
ISBN: 9400728697
Category : Medical
Languages : en
Pages : 459
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Book Description
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.
Author: Neurosciences Institute (New York, N.Y.)
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 808
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Book Description
This book consists of five sections. The first section details methods for analyzing both presynaptic and postsynaptic function and emphasizes the molecular aspects of synapses. It describes ongoing studies of neurotransmitter release, voltage- sensitive ion channels, and electronic transmission at gap junctions. The second section focuses on the growing menagerie of neurotransmitters: their catagorization into chemical families, their relation to ion channels, their modulation by second messenger systems and their role in pharmacologic action. The third section considers the important relationship of transmitter diversity and synaptic types to the behavior of actual cellular networks. All of the studies described in these sections point to the necessity of considering interactions between anatomy, chemistry, physiology and pharmacology if synaptic function is to be understood at any one of these levels of analysis.
Author: Victor Tapias
Publisher: Frontiers Media SA
ISBN: 2889634507
Category :
Languages : en
Pages : 209
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Book Description
Author: Bingwei Lu
Publisher: Springer
ISBN: 9789400712928
Category : Medical
Languages : en
Pages : 260
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Book Description
Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
