Author: W.D. Dietrich
Publisher: Springer Science & Business Media
ISBN: 1461534526
Category : Science
Languages : en
Pages : 375
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Book Description
Neuroscientists from various disciplines have given extraordinary attention to the role of neurotransmitters in the field of neuronal injury. This volume summarizes the original oral and poster contributions which were presented at the symposium, "The Role of Neurotransmitters in Brain Injury," in Key West, Florida, between June 7-9, 1991. This symposium was the official Satellite of Brain-91, the Fifteenth International Symposium on Cerebral Blood Flow and Metabolism, held in Miami the previous week. The two principal goals of the Key West satellite meeting were to document recent progress and, more importantly, to explore future directions for investigative studies of the role of neurotransmitters in brain injury. To achieve these goals we assembled participants from diverse scientific fields and specialties who brought their collective expertise to discussions on the importance of neurotransmitters in neuronal and vascular injury following brain ischemia, trauma, and epilepsy. Their contributions are reflected in this volume. An important section of this volume is devoted to the role of glutamate and glutamatergic receptors in the development of ischemic neuronal damage. Topics covered include the mechanisms of glutamate and other excitatory amino acids, and the role of underlying injury-induced release different glutamatergic receptors in brain injury, including the NMDA and the non-NMDA receptors. The involvement of other neurotransmitters in the process of ischemic brain injury is well established.
Author: Daniel Laskowitz
Publisher: CRC Press
ISBN: 1498766579
Category : Medical
Languages : en
Pages : 412
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Book Description
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309210089
Category : Medical
Languages : en
Pages : 444
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Book Description
Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.
Author: Firas H. Kobeissy
Publisher: CRC Press
ISBN: 1466565993
Category : Science
Languages : en
Pages : 725
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Book Description
Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.
Author: Barbara P. Uzzell
Publisher: Psychology Press
ISBN: 1317779800
Category : Psychology
Languages : en
Pages : 372
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Book Description
Emotions, behaviors, thoughts, creations, planning, daily physical activities, and routines are programmed within our brains. To acquire these capacities, the brain takes time to fully develop--a process that may take the first 20 years of life. Disruptions of the brain involving neurons, axons, dendrites, synapses, neurotransmitters or brain infrastructure produce profound changes in development and functions of the one organ that makes us unique. To understand the functions and development of the brain is difficult enough, but to reverse the consequences of trauma and repair the damage is even more challenging. To meet this challenge and increase understanding, a host of disciplines working and communicating together are required. The International Association for the Study of Traumatic Brain Injury tried to correct this limitation during its meetings of international clinicians, researchers, and scientists from many fields. It was felt that many of the outstanding thoughts and ideas from the participants' most recent meeting and from others working in the field of traumatic brain injury (TBI) should be shared. This book was conceived not as proceedings of the conference, but as a collection of knowledge for those working in the acute and chronic recovery aspects of head injury. This book reflects the importance of the team approach to patients with TBI. The chapter authors come from a diverse array of disciplines--basic science, neurosurgery, neurology, radiology, psychology, neuropsychology, and legal, consumer, and speech/language science. Their contributions provide the most current research and the latest ways of managing a variety of aspects of TBI.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309212243
Category : Medical
Languages : en
Pages : 74
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Book Description
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309288037
Category : Medical
Languages : en
Pages : 356
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Book Description
In the past decade, few subjects at the intersection of medicine and sports have generated as much public interest as sports-related concussions - especially among youth. Despite growing awareness of sports-related concussions and campaigns to educate athletes, coaches, physicians, and parents of young athletes about concussion recognition and management, confusion and controversy persist in many areas. Currently, diagnosis is based primarily on the symptoms reported by the individual rather than on objective diagnostic markers, and there is little empirical evidence for the optimal degree and duration of physical rest needed to promote recovery or the best timing and approach for returning to full physical activity. Sports-Related Concussions in Youth: Improving the Science, Changing the Culture reviews the science of sports-related concussions in youth from elementary school through young adulthood, as well as in military personnel and their dependents. This report recommends actions that can be taken by a range of audiences - including research funding agencies, legislatures, state and school superintendents and athletic directors, military organizations, and equipment manufacturers, as well as youth who participate in sports and their parents - to improve what is known about concussions and to reduce their occurrence. Sports-Related Concussions in Youth finds that while some studies provide useful information, much remains unknown about the extent of concussions in youth; how to diagnose, manage, and prevent concussions; and the short- and long-term consequences of concussions as well as repetitive head impacts that do not result in concussion symptoms. The culture of sports negatively influences athletes' self-reporting of concussion symptoms and their adherence to return-to-play guidance. Athletes, their teammates, and, in some cases, coaches and parents may not fully appreciate the health threats posed by concussions. Similarly, military recruits are immersed in a culture that includes devotion to duty and service before self, and the critical nature of concussions may often go unheeded. According to Sports-Related Concussions in Youth, if the youth sports community can adopt the belief that concussions are serious injuries and emphasize care for players with concussions until they are fully recovered, then the culture in which these athletes perform and compete will become much safer. Improving understanding of the extent, causes, effects, and prevention of sports-related concussions is vitally important for the health and well-being of youth athletes. The findings and recommendations in this report set a direction for research to reach this goal.
Author: Diane Roberts Stoler Ed.D.
Publisher: Penguin
ISBN: 1101631619
Category : Health & Fitness
Languages : en
Pages : 400
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Book Description
A comprehensive guide for improving memory, focus, and quality of life in the aftermath of a concussion. Often presenting itself after a head trauma, concussion— or mild traumatic brain injury (mTBI)— can cause chronic migraines, depression, memory, and sleep problems that can last for years, referred to as post concussion syndrome (PCS). Neuropsychologist and concussion survivor Dr. Diane Roberts Stoler is the authority on all aspects of the recovery process. Coping with Concussion and Mild Traumatic Brain Injury is a lifeline for patients, parents, and other caregivers.
Author: Elaine K. Perry
Publisher: John Benjamins Publishing
ISBN: 9789027251565
Category : Psychology
Languages : en
Pages : 366
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Book Description
This pioneering book explores in depth the role of neurotransmitters in conscious awareness. The central aim is to identify common neural denominators of conscious awareness, informed by the neurochemistry of natural, drug induced and pathological states of consciousness. Chemicals such as acetylcholine and dopamine, which bridge the synaptic gap between neurones, are the 'neurotransmitters in mind' that form the substance of the volume, which is essential reading for all who believe that unravelling mechanisms of consciousness must include these vital systems of the brain.Up-to-date information is provided on: Psychological domains of attention, motivation, memory, sleep and dreaming that define normal states of consciousness. Effects of chemicals that alter or abolish consciousness, including hallucinogens and anaesthetics. Disorders of the brain such as dementia, schizophrenia and depression considered from the novel perspective of the way these affect consciousness, and how this might relate to disturbances in neurotransmission. (Series B)
Author: Jun Chen
Publisher: Springer Science & Business Media
ISBN: 1603271856
Category : Medical
Languages : en
Pages : 490
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Book Description
Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.
