The Role of Maternal Fibroblast Growth Factor Receptors in the Early Development of Xenopus Laevis PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Role of Maternal Fibroblast Growth Factor Receptors in the Early Development of Xenopus Laevis PDF full book. Access full book title The Role of Maternal Fibroblast Growth Factor Receptors in the Early Development of Xenopus Laevis by Michael V. Zuck. Download full books in PDF and EPUB format.
Author: Michael V. Zuck
Publisher:
ISBN:
Category : Fibroblast growth factors
Languages : en
Pages : 244
Get Book Here
Book Description
Author: Michael V. Zuck
Publisher:
ISBN:
Category : Fibroblast growth factors
Languages : en
Pages : 244
Get Book Here
Book Description
Author: Harry Victor Isaacs
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Gordon W. Nash
Publisher:
ISBN:
Category : Embryology
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Christopher Alan D'Jamoos
Publisher:
ISBN:
Category : Fibroblast growth factors
Languages : en
Pages : 162
Get Book Here
Book Description
Author: Wendy Winsor
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
In a search for fibroblast growth factor (FGF)-regulated early response genes, four cDNA fragments were isolated via a polymerase chain reaction-based differential display procedure. The cDNA fragments represent portions of genes that were either activated or repressed in Stage 8 Xenopus laevis explants after a 30 minute treatment with lOOng/ml XFGF-2. One 498bp cDNA fragment, named Band V, represents a gene that is downregulated by FGF treatment. This gene is expressed at Stages 8, 9 and 15 in the developing Xenopus embryo. A Genbank homology search program revealed similarity of Band V to distinct regions in an alternatively spliced myocyte enhancer factor, the v-j- c region of a T-cell receptor gamma chain, a Meprin A beta-subunit precursor and a myosin I heavy chain-like protein. The three other cDNA bands isolated from the differential display were chosen due to apparent upregulation by FGF. The 449bp Band VIA/B cDNA fragment possesses regions of similarity to the reactive centre of murine serine proteinase inhibitor 2.4 and a contrapsin-related MC-7 precursor. Upregulation of Band VIA/B was not confirmed because gene expression could not be detected via PCR in Xenopus explants or throughout development. The third Band 11/12, is a 636bp cDNA fragment whose gene is only expressed at Stage 8 of the developing embryo and was upregulated by FGF-2, in a PCR reaction. A database homology search showed that Band 11/12 was similar to a hypothetical protein. A second, 190bp DNA fragment isolated from Band 12 was a portion of the c-mos protooncogene. The fourth and final cDNA Band 22 is 517bp in size and represents a previously cloned Xenopus 146kDa nuclear splicing factor (Schmidt-Zachmann et aL, 1998). This factor is expressed throughout Xenopus development, and control of Band 22 gene expression by FGF-2 could not be confirmed.
Author: Malgorzata Kloc
Publisher: John Wiley & Sons
ISBN: 1118492811
Category : Science
Languages : en
Pages : 459
Get Book Here
Book Description
Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in various disciplines of biological science. Xenopus Development is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches being used in Xenopus research. Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research. Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis Explores cellular to systems development in key biomedical model organisms Timely synthesis of the field of Xenopus biology Highlights key biomedical and basic biological findings unlocked by Xenopus
Author: Paul T. Sharpe
Publisher: Springer Science & Business Media
ISBN: 1592592708
Category : Science
Languages : en
Pages : 752
Get Book Here
Book Description
Most people have some interest in embryos; this probably results, in part, from their interest in understanding the biological origins of themselves and their offspring and, increasingly, concerns about how environmental change such as pollution might affect human development. Obviously, et- cal considerations preclude experimental studies of human embryos and, c- sequently, the developmental biologist has turned to other species to examine this process. Fortunately, the most significant conclusion to be drawn from the experimental embryology of the last two decades is the manner in which orthologous or closely related molecules are deployed to mediate similar - velopmental processes in both vertebrates and invertebrates. The molecular mechanisms regulating processes fundamental to most animals, such as axial patterning or axon guidance, are frequently conserved during evolution. (It is now widely believed that the differences between phyla and classes are the result of new genes, arising mostly by duplication and divergence of extant sequences, regulating the appearance of derived characters. ) Other vertebrates are obviously most likely to use the same devel- mental mechanisms as humans and, within the vertebrate subphylum, the - parent degree of conservation of developmental mechanism is considerable. It has long been recognized that particular vertebrate species offer either d- tinct advantages in investigating particular stages of development or are - pecially amenable to particular manipulations. No single animal can provide all the answers because not all types of experiments can be carried out on a single species.
Author: Francisco Pelegri
Publisher: Springer
ISBN: 3319460951
Category : Science
Languages : en
Pages : 554
Get Book Here
Book Description
This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems. It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1192
Get Book Here
Book Description
Author: Douglas W. DeSimone
Publisher: Springer Science & Business Media
ISBN: 3642359353
Category : Science
Languages : en
Pages : 260
Get Book Here
Book Description
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.
