The Relationship Between Membrane Lipid Physical State and Membrane Function in Escherichia Coli PDF Download
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Author: Carol Deborah Linden
Publisher:
ISBN:
Category :
Languages : en
Pages : 260
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Book Description
Author: Carol Deborah Linden
Publisher:
ISBN:
Category :
Languages : en
Pages : 260
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Book Description
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Morris Kates
Publisher: Springer Science & Business Media
ISBN: 1468446673
Category : Science
Languages : en
Pages : 698
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Book Description
The aim of this book is to bring together in one volume the current research and thought on the concept of membrane fluidity as a biological phenomenon. The invited articles are intended to review recent develop ments in the areas of membrane research covered and to summarize the current concepts and theories in those areas. The authors have been given ample opportunity to present their thoughts and speculation on membrane fluidity and related phenomena in a more expanded form than is usually possible in reviews of this type. It is hoped that this approach will have a stimulating effect on research and theoretical development in the biomem brane field. The chapters in this book are arranged in three sections, the first of which covers physical studies of membrane fluidity and related phenomena on the molecular level. Included are chapters on intermolecular hydrogen bonding between membrane lipids, thermal analysis of membranes, appli cation of fluorescence and NMR spectrometry to the study of membrane fluidity, and the effect of drugs and other compounds on membrane stability and fluidity. The second section deals with the regulation of membrane fluidity in microorganisms, plants, and higher organisms by factors such as tem perature, fatty acid chain length, lipid desaturation, and polar head group structure.
Author: Evelyn Sofia Tecoma
Publisher:
ISBN:
Category : Escherichia coli
Languages : en
Pages : 336
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Book Description
Author: Guy A. Thompson
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 240
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Book Description
Summarizes the current knowledge on the metabolism of membrane lipids, emphasizing the regulatory interactions. Somewhere between a general textbook and a comprehensive review article, for students who want to apply their learning from a basic biochemistry course to problems involving membranes. Also useful to researchers in related fields, whose work sometimes involves membranes. Extensively updated from the 1980 edition. Annotation copyrighted by Book News, Inc., Portland, OR
Author: Arthur Kaskel Solomon
Publisher: Harvard University Press
ISBN: 9780674581791
Category : Science
Languages : en
Pages : 366
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Book Description
Biological membranes have been under intensive investigation for several decades. Despite very great experimental challenges, membranes are at last beginning to reveal their secrets. In this book, leading investigators of membrane structure and function report on progress in three related fields: specialization of membrane regions, asymmetry in transport properties, and differentiation of cell faces in epithelia. "Specialization at the Molecular Level" is the subject of the first section; in it, the authors consider such problems as the biogenesis of membranes, the geometry of protein-lipid relationships, and the physical properties of membrane receptor-sites. In the second section, "Asymmetry in Transport," such topics as the sodium-potassium pump, proton translocation, and anion transport are covered. The last section is entitled "Polar Faces in Epithelia" and deals with the complex properties of ion transport across the complex membrane environment maintained by surfaces such as the renal tubular epithelia.
Author: Gunnar von Heijne
Publisher: R. G. Landes
ISBN:
Category : Science
Languages : en
Pages : 300
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Book Description
Author: Leif Rilfors
Publisher:
ISBN:
Category :
Languages : en
Pages : 138
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Book Description
Author: Otto Geiger
Publisher: Springer
ISBN: 9783319504292
Category : Science
Languages : en
Pages : 0
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Book Description
Concise chapters, written by experts in the field, cover a wide spectrum of topics on lipid and membrane formation in microbes (Archaea, Bacteria, eukaryotic microbes).All cells are delimited by a lipid membrane, which provides a crucial boundary in any known form of life. Readers will discover significant chapters on microbial lipid-carrying biomolecules and lipid/membrane-associated structures and processes.
Author: John Robert Silvius
Publisher:
ISBN:
Category : Cell membranes
Languages : en
Pages : 0
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Book Description
The aims of this work were twofold: first, to generate a biologi cal membrane system in which the lipid fatty acyl composition can be var ied essentially at will, and to study the relationship of lipid proper ties to membrane function in such a system, and secondly, to synthesize and characterize some novel phospholipids which provide valuable model systems whose behavior is relevant to that of the lipids in the biologi cal membrane studied. Toward the former objective, I have developed a simple method for converting the simple cell wall-less prokaryote Acholeplasma laidlawii B into a total fatty acid auxotroph, using avidin to completely inhibit de novo fatty acid synthesis and chain elongation kn vivo . Cells thus treated can grow well when any of a wide variety of fatty acids are add ed to the culture medium, and if a single fatty acid is added, the cells incorporate it into their membrane lipids to the extent of 95+% of the total lipid acyl chains if the fatty acid can support cell growth. The cellular growth-supporting ability of a fatty acid appears to rest on its physical and not its metabolic properties. 'Fatty acid-homogeneous' membranes or membrane lipids, obtained from cells grown with avidin plus any of a number of single fatty acids which are good growth substrates, exhibit a markedly sharper lipid phase transition by differential ther mal analysis than do normal membranes or membrane lipids, which have a heterogeneous fatty acyl composition. The protein and lipid head-group composition of fatty acid-homogeneous membranes varies somewhat depend ing on the nature of the lipid acyl chains, but a variety of experiments indicate that such variations are unlikely to produce changes of a qualitative nature in the physical behavior of the membrane lipids. The potential for manipulation of lipid fatty acyl chains and physical pro perties in the A. laidlawii B membrane has been used to study the physi cal basis of the membrane lipid effects on the temperature dependence of a membrane enzyme activity, the (Na + ,Mg 2 +)-ATPase, which appears to func tion as an osmoregulatory cation pump jui vivo . My results, analyzed in the light of an extensive theoretical analysis of Arrhenius plot behavi or, suggest that the ATPase's catalytic activity is not altered by changes in the lipids around it so long as they are in the liquid-crys talline state, but that a membrane lipid phase transition occurring on cooling the membrane can cause the boundary lipids of the ATPase to en ter a 'gel-like' state and thereby to inactivate the enzyme. Working toward the second objective noted above, that of develop ing and characterizing good pure-lipid model systems for the fatty acid- homogeneous A. laidlawii B membrane, I synthesized a number of branched- chain, odd-chain saturated, monounsaturated and cyclopropane fatty acids and their phosphatidylcholine (PC) derivatives. I then characterized the thermotropic behavior of the fully hydrated PC's by differential thermal analysis. By studying the effect of acyl chain length and struc ture on the thermotropic behavior of hydrated diacyl PC's, I have been able to draw various conclusions regarding the nature of the acyl chain packing in the gel state and regarding the function of various types of methyl-branched and alicyclic lipid acyl chains in membranes. Finally, I have shown that the gel-to-liquid-crystalline phase transition tem peratures of pure PC's and of A. laidlawii B membrane lipids of like fat ty acyl composition correlate very well, indicating that the lipid acyl chain interactions in the two systems are fundamentally similar and that the former lipid system is in fact a good model for the biological membrane.
