The Polyol Paradigm and Complications of Diabetes PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Polyol Paradigm and Complications of Diabetes PDF full book. Access full book title The Polyol Paradigm and Complications of Diabetes by Margo P. Cohen. Download full books in PDF and EPUB format.
Author: Margo P. Cohen
Publisher: Springer Science & Business Media
ISBN: 1461246709
Category : Medical
Languages : en
Pages : 151
Get Book Here
Book Description
In the last decade, it has become increasingly evident that the clini cal and morphologic changes underlying many of the complications of diabetes, including cataract formation, retinopathy, nephropathy, neuropathy, and macrovascular disease, are preceded by a variety of disturbances of biochemical and physiologic origin. Dr. Cohen has recently written a superb monograph, entitled Diabetes and Protein Glycosylation: Measurement and Biologic Relevance, in which she thoroughly explores how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for main tenance of long-term euglycemia. In the present volume, The Polyol Paradigm and Complications of Diabetes, she reviews, in a most succinct and thorough manner, how another biochemical mechan ism, involving the polyol pathway, is involved in the pathogenesis of such diabetes complications as retinopathy, neuropathy, nephropa thy, and cataract formation. Dr. Cohen gives us a clearly written and comprehensive mono graph, reviewing the chemistry of the polyol pathway and of the aldose reductase inhibitors, and the pathophysiologic significance of increased polyol pathway activity in a variety of tissues affected by Vlll Foreword diabetes mellitus. She insightfully describes the relationship of increased polyol pathway activity to altered metabolism of inositol containing phospholipids and to changes in various tissue concentra tions of myo-inositol. Finally, she provides us with a careful review of the existing experimental and clinical studies with a variety of different aldose reductase inhibitors that have been and are being performed in the hope of preventing or reversing long-term compli cations of diabetes.
Author: Margo P. Cohen
Publisher: Springer Science & Business Media
ISBN: 1461246709
Category : Medical
Languages : en
Pages : 151
Get Book Here
Book Description
In the last decade, it has become increasingly evident that the clini cal and morphologic changes underlying many of the complications of diabetes, including cataract formation, retinopathy, nephropathy, neuropathy, and macrovascular disease, are preceded by a variety of disturbances of biochemical and physiologic origin. Dr. Cohen has recently written a superb monograph, entitled Diabetes and Protein Glycosylation: Measurement and Biologic Relevance, in which she thoroughly explores how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for main tenance of long-term euglycemia. In the present volume, The Polyol Paradigm and Complications of Diabetes, she reviews, in a most succinct and thorough manner, how another biochemical mechan ism, involving the polyol pathway, is involved in the pathogenesis of such diabetes complications as retinopathy, neuropathy, nephropa thy, and cataract formation. Dr. Cohen gives us a clearly written and comprehensive mono graph, reviewing the chemistry of the polyol pathway and of the aldose reductase inhibitors, and the pathophysiologic significance of increased polyol pathway activity in a variety of tissues affected by Vlll Foreword diabetes mellitus. She insightfully describes the relationship of increased polyol pathway activity to altered metabolism of inositol containing phospholipids and to changes in various tissue concentra tions of myo-inositol. Finally, she provides us with a careful review of the existing experimental and clinical studies with a variety of different aldose reductase inhibitors that have been and are being performed in the hope of preventing or reversing long-term compli cations of diabetes.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1712
Get Book Here
Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Derek LeRoith
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781740975
Category : Medical
Languages : es
Pages : 1606
Get Book Here
Book Description
Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.
Author: Oluwafemi Oguntibeju
Publisher: BoD – Books on Demand
ISBN: 9535112155
Category : Medical
Languages : en
Pages : 384
Get Book Here
Book Description
The human system employs the use of endogenous enzymatic as well as non-enzymatic antioxidant defence systems against the onslaught of free radicals and oxidative stress. Enzymatic antioxidants and non-enzymatic antioxidants work synergistically with each other, using different mechanisms against different free radicals and stages of oxidative stress. Dietary and lifestyle modifications are seen as the mainstay of treatment and management of chronic diseases such as diabetes mellitus. The major aims of dietary and lifestyle changes are to reduce weight, improve glycaemic control and reduce the risk of coronary heart disease, which accounts for 70- 80% of deaths among those with diabetes. It is also important to note that medicinal plants have been used as medicines since ancient time, and continue to play significant role even in modern medicine in management and treatment of chronic diseases. Impressive numbers of modern therapeutic agents have been developed from plants. Phytochemicals have been isolated and characterised from fruits such as grapes and apples, vegetables such as broccoli and onion, spices such as turmeric, beverages such as green tea and red wine, as well as many other sources. The WHO estimates that approximately 80% of the worlds inhabitants rely on traditional medicine for their primary health care and many medicinal plants have ethno-medical claims of usefulness in the treatment of diabetes and other chronic diseases globally, and have been employed empirically in antidiabetic, antihyperlipidemic, antihypertensive, antinflammatory and antiparasitic remedies. This book examines the role of antioxidant-rich natural products in management and treatment of diabetes and other chronic diseases.
Author: Marilyn Moffat
Publisher: SLACK Incorporated
ISBN: 9781556426704
Category : Nursing care plans
Languages : en
Pages : 172
Get Book Here
Book Description
Integumentary Essentials: Applying the Preferred Physical Therapist Practice PatternsSM answers the call to what today’s physical therapy students and clinicians are looking for when integrating the Guide to Physical Therapist Practice as it relates to the integumentary system in clinical care. As a part of Essentials in Physical Therapy led by Series Editor Dr. Marilyn Moffat, Integumentary Essentials: Applying the Preferred Physical Therapist Practice PatternsSM is edited by Katherine Biggs Harris in a user-friendly format that not only brings together the conceptual frameworks of the Guide language, but also parallels the patterns of the Guide. In each case, where appropriate, a brief review of the pertinent anatomy, physiology, pathophysiology, imaging, and pharmacology is provided. Each pattern then details three diversified case studies coinciding with the Guide format. The physical therapist examination, including history, systems review, and specific tests and measures for each case, as well as evaluation, diagnosis, prognosis, plan of care, and evidence-based interventions are also addressed. Sample Cases in Some of the Practice Patterns Include: -Primary Prevention/Risk Reduction for Integumentary Disorders: A patient with multiple sclerosis; an octogenarian in skeletal traction; a patient with rheumatoid arthritis -Impaired Integumentary Integrity Associated With Superficial Skin Involvement: A patient burned from a splash injury; a patient with a CVA and a pressure area; a patient with a deep vein thrombosis, cellulitis and edema -Impaired Integumentary Integrity Associated With Partial-Thickness Skin Involvement and Scar Formation: A patient with a vascular ulcer; a patient with mixed vascular disease and pressure ulcer; a patient with a superficial partial-thickness burn -Impaired Integumentary Integrity Associated With Full-Thickness Skin Involvement and Scar Formation: A patient with a neuropathic wound; a patient with a full-thickness traumatic, arterial insufficient wound; a patient with a full-thickness infected wound -Impaired Integumentary Integrity Associated With Skin Involvement Extending Into Fascia, Muscle, Bone, and Scar Formation: A patient with infection in a post-traumatic wound extending to the bo≠ a patient pre-operative for free flap surgical coverage of a sacral pressure ulcer; a patient post free flap reconstruction of an electrical wound At long last, Dr. Marilyn Moffat and Katherine Biggs Harris have created a book that will integrate the parameters of the Guide, as it relates to the integumentary system, into the practice arena, that not only covers the material but also allows for a problem-solving approach to learning for educators and students.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1028
Get Book Here
Book Description
Author: Colin G. Scanes
Publisher: Elsevier
ISBN: 0323150128
Category : Science
Languages : en
Pages : 445
Get Book Here
Book Description
Development, Maturation, and Senescence of Neuroendocrine Systems: A Comparative Approach discusses the various phases of the aging continuum of neuroendocrine systems. This book explores the fundamental and physiological component of animals, which is an essential contributor to senescence. Organized into three parts encompassing 21 chapters, this volume starts with a discussion of the concept of neurosecretory neuron that was introduced by Ernst Scharrer in 1928. This book discusses the challenges in the study of the development of the neuroendocrine system in insects, with a focus on Lepidoptera. Other chapters consider the neuroendocrine mechanisms that control the physiological processes in crustaceans. The reader is then introduced to the major neurohemal structures in crustaceans, including the sinus gland, the pericardial organs, and the post-commissural organs. The final chapter discusses the two brain systems that show impact of endogenous steroids that account for subsets of senescent changes. This book is a valuable resource for neurobiologists, molecular biologists, and immunologists.
Author:
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 352
Get Book Here
Book Description
Author: Sics Editore
Publisher: SICS Editore
ISBN: 8869304930
Category : Medical
Languages : en
Pages : 40
Get Book Here
Book Description
Screening for diabetic retinopathy prevents blindness and visual impairment and offers a good cost-benefit ratio . Fundus photography is a more sensitive screening tool than ophthalmoscopy . The screening programme can be the responsibility of the primary care physician until the patient develops more than mild changes or the sight worsens. Thereafter decisions about the frequency and methods of screening are the responsibility of an ophthalmologist, as are all decisions regarding treatment needs (based on fundus photographs or clinical examination). The maintenance of optimal glycaemic control and risk factor management are the responsibility of the patient and those caring for him/her. The treatment of all changes within the eye belongs to an ophthalmologist. Visual rehabilitation should be started as soon as sight-threatening changes are noted in the fundus of a diabetic patient.
Author: Enzo Bonora
Publisher: Springer
ISBN: 9783030366933
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
This book provides the reader with comprehensive information on the interactions between diabetes and a wide range of comorbid conditions and on disease management in such patients. It has the aim of empowering health care providers in their daily battle against the disease and its consequences. Diabetes has been identified by WHO and the United Nations as a medical emergency because of the increase in its global prevalence, which may reach one billion in three to four decades if the trend remains unchanged. Despite improved care that is helping to prolong life, diabetes impacts substantially on the quality of life of those affected and kills or disables several million people each year. The disease is systemic because all organs, tissues, and cells suffer in the presence of hyperglycemia and are damaged by the diabetic milieu. Unfortunately, most patients with diabetes will consequently experience chronic diabetic complications. This book will be of value for all physicians and nurses who care for patients with diabetes and face the challenge of treating hyperglycemia and related acute and chronic complications.
