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Author: David A. Jans
Publisher: Springer Science & Business Media
ISBN: 1475706804
Category : Medical
Languages : en
Pages : 228
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Book Description
Author: David A. Jans
Publisher: Springer Science & Business Media
ISBN: 1475706804
Category : Medical
Languages : en
Pages : 228
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Book Description
Author:
Publisher: Academic Press
ISBN: 0080584896
Category : Science
Languages : en
Pages : 507
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Book Description
Current Topics in Membranes and Transport
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 1483273687
Category : Science
Languages : en
Pages : 455
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Book Description
The Receptors, Volume II deals with receptors for somatostatin, vitamin D, insulin, and animal viruses, as well as for the ?2-adrenergic and Ah systems. The significance of translational modifications of receptor ligands is discussed, along with the mechanisms of receptor-ligand interactions. The role of receptors in development and their regulation by tumors are also considered. Comprised of 12 chapters, this volume begins with a detailed account of the vitamin D receptor, paying particular attention to its biochemical and physical properties as well as its mechanism of action. The discussion then turns to experimental discrimination between alternative mechanistic models for the receptor-mediated stimulation of adenylate cyclase; the role of microaggregation in hormone-receptor-effector interactions; and the biology and biochemistry of the Ah receptor. Subsequent chapters explore the interactions of animal viruses with cell surface receptors; insulin receptors; determination of the size of neurotransmitter receptors by radiation inactivation-target size analysis; and protein glycosylation and receptor-ligand interactions. This book will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.
Author: George Poste
Publisher: Springer Science & Business Media
ISBN: 146132131X
Category : Medical
Languages : en
Pages : 446
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Book Description
It is less than 80 years since John Newport Langley first proposed the role of "receptive substances" as the site of drug action from his obser vations on the effects of nicotine and curare at the myoneural junction. The many advances in our understanding of receptor biology that have occurred during the intervening period mirror the extraordinary growth of knowledge in the biological sciences and in cell and molecular biology in particular. Receptor biology, in common with many other topics in contemporary biology, is on the threshold of a transition from being a descriptive, phenomenological discipline to one in which underlying mechanisms and regulatory principles can be defined with increasing pre cision. This change, together with the evolution of powerful analytical techniques and timely convergence of ideas from a number of previously separate fields of inquiry, is generating an increasingly unified theoretical and experimental framework for the study of receptor function. These themes, and the mood of anticipation that a real understanding of receptor function in health and disease is emerging, are reflected in in this volume, which summarizes the proceedings of the Sec the papers ond Smith Kline & French Research Symposium on New Horizons in Therapeutics held in Philadelphia in 1984.
Author: T. Kenakin
Publisher: Springer Science & Business Media
ISBN: 364257081X
Category : Medical
Languages : en
Pages : 456
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Book Description
This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A. J. CLARK, authored the fourth volume of this series 63 years ago. In that volume CLARK further developed his version of receptor theory first described four years earlier in his classic book The Mode of Action of Drugs. An examination of the topics covered in volume 4 reveals a striking similarity to the topics covered in this present volume; pharmacologists today are still as interested in unlocking the secrets of dose-response relationships to reveal the biological and che mical basis of drug action as they were over half a century ago. Sections in that 1937 volume such as "Curves relating exposure to drugs with biological effects" and "Implications of monomolecular theory" show Clark's keen insight into the essential questions that required answers to move pharma cology forward. With the advent of molecular biological cloning of human receptors has come a transformation of receptor pharmacology. Thus the expression of human receptors into surrogate host cells helped unlock secrets of receptor mechanisms and stimulus-transduction pathways. To a large extent, this elim inates the leap of faith required to apply receptor activity of drugs tested on animal receptor systems to the human therapeutic arena. However, a new leap of faith concerning the veracity of the effects found in recombinant systems with respect to natural ones is now required.
Author: Osamu Hayaishi
Publisher: CRC Press
ISBN: 1040294952
Category : Medical
Languages : en
Pages : 254
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Book Description
This book deals with molecular neurobiology based on neurochemical approaches and focuses on neural plasticity studied by neurophysiological methods. It offers discussions on prospects of neuroscience from the respective stances of the participants.
Author: P. CUATRECASAS AND M. F. GREAVES
Publisher: Springer
ISBN: 1489968628
Category : Science
Languages : en
Pages : 207
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Book Description
Author:
Publisher: Academic Press
ISBN: 0080586244
Category : Science
Languages : en
Pages : 353
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Book Description
International Review of Cytology
Author: Arthur Christopoulos
Publisher: CRC Press
ISBN: 1420041878
Category : Medical
Languages : en
Pages : 260
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Book Description
Up to the last decade or so, most general modeling approaches to the study of molecular components of biological responses have required significant amount of computer time, expertise, and resources, as well as highly specialized and often custom-written programs. With Biomedical Applications of Computer Modeling you don't have to be a computer sci
Author: Lee A. Segel
Publisher: Cambridge University Press
ISBN: 9780521391849
Category : Mathematics
Languages : en
Pages : 234
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Book Description
This book demonstrates how an understanding of biological kinetics can lead to knowledge about the biological model being examined.
