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Author: Ningning Hou
Publisher: Frontiers Media SA
ISBN: 2832550665
Category : Medical
Languages : en
Pages : 160
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Book Description
Metabolic syndrome (MetS), including obesity, hyperglycemia, hyperlipidemia, hyperinsulinemia, are associated with disturbed energy homeostasis, limited whole-body insulin sensitivity, and an increased risk of cardiovascular and chronic kidney disease (CKD). The prospective and cross-sectional studies have shown a close association between the MetS and CKD. Chronic inflammation and vascular dysfunction are two key MetS-related etiological factors for renal injury. CKD is characterized by mitochondrial dysfunction, oxidative stress, and aberrant autophagy at the cellular level, which is also typical of metabolic disorders. However, the relationship and mechanism between metabolic disease and chronic kidney dysfunction still call for deeper understanding. This Research Topic aims to gather both Reviews and Original Research articles focused on discovering the truth behind the phenomenon that glucose and lipid metabolic disorders and obesity have important public health implications in terms of individuals with CKD. The studies covering new insights to determine the link between MetS-related immunity response and renal dysfunction will also be considered.
Author: Ningning Hou
Publisher: Frontiers Media SA
ISBN: 2832550665
Category : Medical
Languages : en
Pages : 160
Get Book Here
Book Description
Metabolic syndrome (MetS), including obesity, hyperglycemia, hyperlipidemia, hyperinsulinemia, are associated with disturbed energy homeostasis, limited whole-body insulin sensitivity, and an increased risk of cardiovascular and chronic kidney disease (CKD). The prospective and cross-sectional studies have shown a close association between the MetS and CKD. Chronic inflammation and vascular dysfunction are two key MetS-related etiological factors for renal injury. CKD is characterized by mitochondrial dysfunction, oxidative stress, and aberrant autophagy at the cellular level, which is also typical of metabolic disorders. However, the relationship and mechanism between metabolic disease and chronic kidney dysfunction still call for deeper understanding. This Research Topic aims to gather both Reviews and Original Research articles focused on discovering the truth behind the phenomenon that glucose and lipid metabolic disorders and obesity have important public health implications in terms of individuals with CKD. The studies covering new insights to determine the link between MetS-related immunity response and renal dysfunction will also be considered.
Author: Ningning Hou
Publisher: Frontiers Media SA
ISBN: 2832503535
Category : Medical
Languages : en
Pages : 116
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Book Description
Author: William F. Keane
Publisher: Karger Medical and Scientific Publishers
ISBN: 9783805563895
Category : Medical
Languages : en
Pages : 248
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Book Description
During the past decade, experimental and clinical studies have suggested that dyslipidemia may be an important risk factor for the progression of renal disease. This volume explores in great detail recent advances in our understanding of the pathogenesis and treatment of this common complication of progressive renal injury. In the experimental investigations presented, emphasis is placed on specific disturbances of lipids that are seen in progressive renal disease including the effects of oxidatively modified lipoproteins and Lp(a) on various functions of the glomerular cells. Clinical studies have identified dyslipidemia as a risk factor for progressive renal disease in diabetes mellitus, various non-diabetic renal diseases, and most recently in patients with progressive renal allograft loss. An emerging interest in the genetics of dyslipidemia has recently arisen and this topic as it specifically relates to progressive renal disease is discussed. The final section of the book offers new insights into the mechanisms of action of antilipemic therapy used in the treatment of dyslipidemia. This volume should be read by all nephrologists caring for patients with progressive renal disease and by physicians interested in the biology of lipids, diabetes and essential hypertension.
Author: Andrew J. Krentz
Publisher: Springer
ISBN: 3030117480
Category : Medical
Languages : en
Pages : 557
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Book Description
This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Author: Neil N. Turner
Publisher: Oxford University Press
ISBN: 0191017655
Category : Medical
Languages : en
Pages : 3045
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Book Description
This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.
Author: Neal Halfon
Publisher: Springer
ISBN: 3319471430
Category : Medical
Languages : en
Pages : 667
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Book Description
This book is open access under a CC BY 4.0 license. This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.
Author: John A. Kellum
Publisher: Oxford University Press
ISBN: 019022553X
Category : Medical
Languages : en
Pages : 329
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Book Description
Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance for the management of critically ill patients with acute renal failure, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice.
Author: Terry Mahan Buttaro
Publisher: Elsevier Health Sciences
ISBN: 0323355218
Category : Medical
Languages : en
Pages : 1717
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Book Description
Prepare for success in today's fast-paced, collaborative healthcare environment! Offering expert perspectives from a variety of primary care and nurse practitioners, Primary Care: A Collaborative Practice, 5th Edition helps you diagnose, treat, and manage hundreds of adult disorders. Care recommendations indicate when to consult with physicians or specialists, and when to refer patients to an emergency facility. This edition includes six new chapters, a fresh new design, the latest evidence-based guidelines, and a new emphasis on clinical reasoning. Combining academic and clinical expertise, an author team led by Terry Mahan Buttaro shows NPs how to provide effective, truly interdisciplinary health care. UNIQUE! A collaborative perspective promotes seamless continuity of care, with chapters written by NPs, physicians, PAs, and other primary care providers. Comprehensive, evidence-based content covers every major disorder of adults seen in the outpatient office setting, reflects today's best practices, and includes the knowledge you need for the NP/DNP level of practice. A consistent format in each chapter is used to describe disorders, facilitating easier learning and quick clinical reference. Diagnostics and Differential Diagnosis boxes provide a quick reference for diagnosing disorders and making care management decisions. Complementary and alternative therapies are addressed where supported by solid research evidence. Referral icons highlight situations calling for specialist referral or emergency referral. NEW chapters cover topics including transitional care, risk management, LGBTQ patient care, bullous pemphigoid, pulmonary embolism, and dysphagia. NEW! An emphasis on clinical reasoning helps you develop skills in diagnosis and treatment, with coverage moving away from pathophysiology and toward diagnostic reasoning and disease management — including pharmacologic management. NEW focus on interdisciplinary care underscores the importance of interprofessional education and practice, and includes Interdisciplinary Management features. UPDATED chapters reflect the latest literature and evidence-based treatment guidelines, including new content on the Affordable Care Act as well as new coverage of patient satisfaction metrics, quality metrics, value-based purchasing, pharmacogenetics/genomics, and teen pregnancy and abnormal pregnancy. NEW quick-reference features make it easier to locate important information, through colorful section tabs, bulleted summaries, additional algorithms, a more logical table of contents, an Index to Standardized Treatment Guidelines, and a Reference to Common Laboratory Values.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 2068
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author: Severin Ringoir
Publisher: Springer Science & Business Media
ISBN: 1468454455
Category : Science
Languages : en
Pages : 292
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Book Description
The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.
