The Immunological Consequences of Regulated Cell Death in Infection and Inflammation PDF Download
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Author: Bart Tummers
Publisher: Frontiers Media SA
ISBN: 2832505317
Category : Medical
Languages : en
Pages : 165
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Book Description
Author: Bart Tummers
Publisher: Frontiers Media SA
ISBN: 2832505317
Category : Medical
Languages : en
Pages : 165
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Book Description
Author: Thomas Kaufmann
Publisher: Frontiers Media SA
ISBN: 288963695X
Category :
Languages : en
Pages : 134
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Book Description
Programmed cell death (PCD) is central in maintaining the life of multicellular organisms, during development as well as in healthy adulthood or in the context of disease. The best understood form of PCD is apoptosis, a caspase mediated, immunologically silent cell death that can be initiated in probably all cell types upon aging, lack of growth support, critical damage or infection. One of the key pathways of apoptosis involves mitochondrial outer membrane permeabilization (MOMP), a process tightly regulated by members of the BCL-2 family. Whereas PCD and apoptosis were used synonymously in the past, other forms of PCD have been discovered more recently, including RIPK1/3- and MLKL-dependent necroptosis, resulting in a necrotic phenotype, and pyroptosis. Interestingly, key components of the necroptotic pathway are actively suppressed by apoptotic caspases, and this interconnection allows a switch in cell death modalities with greatly impact on the host’s immune response. Recent findings link mitochondria and/or MOMP to non-apoptotic forms of PCD, including ferroptosis and necroptosis, putting this organelle even more in the center of cellular death. This article collection highlights the exciting potential and as yet undiscovered regulation of programmed cell death that can impact the immune system and its response.
Author: S.-Y. Seong
Publisher: Frontiers Media SA
ISBN: 2889743543
Category : Medical
Languages : en
Pages : 138
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Book Description
Author: Bharat B. Aggarwal
Publisher: Springer
ISBN: 3034808372
Category : Medical
Languages : en
Pages : 489
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Book Description
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author: Adriano Rossi
Publisher: Springer Science & Business Media
ISBN: 376437506X
Category : Medical
Languages : en
Pages : 246
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Book Description
This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: James Winkler
Publisher: Birkhäuser
ISBN: 3034887418
Category : Medical
Languages : en
Pages : 268
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Book Description
Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. However, many disease conditions utilize apoptosis for pathological ends, resulting in inappropriate cell death and tissue destruction. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases.
Author: John C. Marshall
Publisher: Springer Science & Business Media
ISBN: 9783540425892
Category : Medical
Languages : en
Pages : 458
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Book Description
This book brings together basic scientists or clinicians from a variety of different backgrounds - immunology, infectious diseases or critical care - who share a common interest in understanding the changes that occur in immune responses in sepsis. It provides an up-to-date and unrivalled synthesis of current research in this rapidly developing field.
Author: Han-Ming Shen
Publisher: Springer Science & Business Media
ISBN: 1461482208
Category : Science
Languages : en
Pages : 402
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Book Description
Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.
Author: Jixin Zhong
Publisher: Frontiers Media SA
ISBN: 2889459160
Category :
Languages : en
Pages : 580
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
