THE HUMAN CIRCULATING MICRORNA MIR-28-3P IS A POTENTIAL BIOMARKER FOR ISCHEMIC STROKE ETIOLOGY CLASSIFICATION. PDF Download
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Author: Elena Jimenez-Xarrie
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Background and Aims:Cardioembolic and large-artery atherothrombosis (LAAT) ischemic stroke are two of the most frequent ischemic stroke etiologies. In some patients, it is not straightforward to find the stroke cause and it remains undetermined. In this context, biomarkers would be a useful diagnostic tool. MicroRNAs (miRNA) have demonstrated potential as biomarkers as they can be detected in blood, are stable, and change dynamically with pathologic processes. The aim of this study was to identify a distinctive miRNA expression profile between cardioembolic and LAAT stroke patients.Methods:A non-targeted screening analysis was performed analyzing 179 miRNAs in plasma from 3 groups: cardioembolic patients (n=8), LAAT patients (n=8) and healthy controls (n=8) with Serum/Plasma Focus microRNA Panel (Exiqon). Afterwards, with the selected miRNAs in the screening phase, a validation analysis was performed with 17 patients in each group and 8 in control group. The 2-u0394Ct relative expression levels were calculated. MiR-29a-3p was used as endogenous control for normalization. Non-parametric Kruskall-Wallis test was used for statistical analysis.Results:In the screening phase, 7 candidate miRNAs (miR-378a-3p, miR-421, miR-127-3p, miR-136-3p, miR-28-3p, miR-629-5p and miR-7-5p) with p
Author: Elena Jimenez-Xarrie
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Background and Aims:Cardioembolic and large-artery atherothrombosis (LAAT) ischemic stroke are two of the most frequent ischemic stroke etiologies. In some patients, it is not straightforward to find the stroke cause and it remains undetermined. In this context, biomarkers would be a useful diagnostic tool. MicroRNAs (miRNA) have demonstrated potential as biomarkers as they can be detected in blood, are stable, and change dynamically with pathologic processes. The aim of this study was to identify a distinctive miRNA expression profile between cardioembolic and LAAT stroke patients.Methods:A non-targeted screening analysis was performed analyzing 179 miRNAs in plasma from 3 groups: cardioembolic patients (n=8), LAAT patients (n=8) and healthy controls (n=8) with Serum/Plasma Focus microRNA Panel (Exiqon). Afterwards, with the selected miRNAs in the screening phase, a validation analysis was performed with 17 patients in each group and 8 in control group. The 2-u0394Ct relative expression levels were calculated. MiR-29a-3p was used as endogenous control for normalization. Non-parametric Kruskall-Wallis test was used for statistical analysis.Results:In the screening phase, 7 candidate miRNAs (miR-378a-3p, miR-421, miR-127-3p, miR-136-3p, miR-28-3p, miR-629-5p and miR-7-5p) with p
Author: Yinong Huang
Publisher: Frontiers Media SA
ISBN: 2832536832
Category : Medical
Languages : en
Pages : 220
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Book Description
Author: Philip V Peplow
Publisher: Royal Society of Chemistry
ISBN: 1788017811
Category : Science
Languages : en
Pages : 500
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Book Description
From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.
Author: World Health Organization
Publisher:
ISBN: 9789241565707
Category :
Languages : en
Pages : 126
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Book Description
World Health Statistics 2019 summarizes recent trends and levels in life expectancy and causes of death, and reports on the health and health-related Sustainable Development Goals (SDGs) and associated targets. Where possible, the 2019 report disaggregates data by WHO region, World Bank income group, and sex; it also discusses differences in health status and access to preventive and curative services, particularly in relation to differences between men and women.
Author: Tilo Kircher
Publisher: Cambridge University Press
ISBN: 9780521533508
Category : Medical
Languages : en
Pages : 502
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Book Description
This 2003 book focuses on neuropsychiatric models of self-consciousness, set against introductory essays describing the philosophical, historical and psychological approaches.
Author: Junjie Xiao
Publisher: Springer
ISBN: 9811043973
Category : Science
Languages : en
Pages : 300
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Book Description
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.
Author: Vijay Nambi
Publisher: Elsevier Health Sciences
ISBN: 0323548369
Category : Medical
Languages : en
Pages : 400
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Book Description
Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today’s available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.
Author: Philip V. Peplow
Publisher: Humana
ISBN: 9781493996810
Category : Medical
Languages : en
Pages : 0
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Book Description
This volume presents the latest data on recent achievements in new and emerging technologies for stroke biomarkers and innovations in stroke assessment. The topics discussed in this book explore the role of upcoming biomarkers in different types of stroke, and explores techniques that will allow researchers to be more effective when approaching clinical management and patient care. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to ensure successful results in the laboratory. Cutting-edge and comprehensive, Stroke Biomarkers is a valuable resource for both experimental and clinical scientists interested in expanding their knowledge in the field of stroke research.
Author: Rajanikant G. K.
Publisher: Springer
ISBN: 9789811548000
Category : Medical
Languages : en
Pages : 0
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Book Description
There has been an enormous increase in information relating to microRNA (miRNA) and its strategic role in numerous diseases. This book reviews the emerging role of microRNAs in cerebral ischemia, providing comprehensive details of the links between this small RNA molecule and ischemic stroke, the more prevalent of the two main types of stroke. The chapters address questions relating to microRNA’s function in various pathological features of stroke, like oxidative stress, excitotoxicity and cell death, as well as its role as a biomarker and diagnostic agent, and the current therapeutic interventions. Further, the book highlights the latest research on how miRNAs contribute to neuroregeneration following stroke, discussing the myriad computational tools and databases used in miRNA research, and decsribes how how miRNA modulates other cerebrovascular diseases. The book concludes with fresh insights into the effect of long non-coding RNA in cerebral ischemia.
Author: Y-h. Taguchi
Publisher: MDPI
ISBN: 3038977683
Category : Science
Languages : en
Pages : 348
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Book Description
This book includes updated information about microRNA regulation, for example, in the fields of circular RNAs, multiomics analysis, biomarkers and oncogenes. The variety of topics included in this book reaffirms the extent to which microRNA regulation affects biological processes. Although microRNAs are not translated to proteins, their importance for biological processes is not less than proteins. An understanding of their roles in various biological processes is critical to understanding gene function in these biological processes. Although non-coding RNAs other than microRNAs have recently come under investigation, microRNA still remains the front runner as the subject of genetic and biological studies. In reading the collection of papers, readers can grasp the most updated information regarding microRNA regulation, which will continue to be an important topic in genetics and biology.
