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Author: Dan L. Lindsley
Publisher: Academic Press
ISBN: 0323139841
Category : Science
Languages : en
Pages : 1144
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Book Description
Dedicated to the memory of George Lefevre in recognition of his exhaustive cytogenetic analysis of the X chromosome, The Genome of Drosophila melanogaster is the complete compendium of what is known about the genes and chromosomes of this widely used model organism. The volume is an up-to-date revision of Lindsley and Grell's 1968 work, Genetic Variations of Drosophila melanogaster. The new edition contains complete descriptions of normal and mutant genes including phenotypic, cytological, molecular, and bibliographic information. In addition, it describes thousands of recorded chromosome rearrangements used in research on Drosophila. This handbook and its accompanying polytene chromosome maps, are sturdily bound into the book as foldouts and available as a separate set, are essential research tools for the Drosophila community. - Describes phenotype, cytology, and molecular biology of all recorded genes of Drosophila melanogaster, plus references to the literature - Describes normal chromosome complement, special chromosome constructs, transposable elements, departures from diploidy, satellite sequences, and nonchromosomal inheritance - Describes all recorded chromosome rearrangements of Drosophila melanogaster as of the end of 1989 Contains the cytogenetic map of all genes as of mid-1991 - Contains the original polytene maps of C.B. Bridges, plus G. Lefevre's photographic equivalents, and the detailed maps of the chromosome arms produced by C.B. and P.M. Bridges - All maps are reprinted as high-quality foldouts sturdily bound into the volume - Maps may also be purchased separately in an eight-map packet, for laboratory and student use
Author: Dan L. Lindsley
Publisher: Academic Press
ISBN: 0323139841
Category : Science
Languages : en
Pages : 1144
Get Book Here
Book Description
Dedicated to the memory of George Lefevre in recognition of his exhaustive cytogenetic analysis of the X chromosome, The Genome of Drosophila melanogaster is the complete compendium of what is known about the genes and chromosomes of this widely used model organism. The volume is an up-to-date revision of Lindsley and Grell's 1968 work, Genetic Variations of Drosophila melanogaster. The new edition contains complete descriptions of normal and mutant genes including phenotypic, cytological, molecular, and bibliographic information. In addition, it describes thousands of recorded chromosome rearrangements used in research on Drosophila. This handbook and its accompanying polytene chromosome maps, are sturdily bound into the book as foldouts and available as a separate set, are essential research tools for the Drosophila community. - Describes phenotype, cytology, and molecular biology of all recorded genes of Drosophila melanogaster, plus references to the literature - Describes normal chromosome complement, special chromosome constructs, transposable elements, departures from diploidy, satellite sequences, and nonchromosomal inheritance - Describes all recorded chromosome rearrangements of Drosophila melanogaster as of the end of 1989 Contains the cytogenetic map of all genes as of mid-1991 - Contains the original polytene maps of C.B. Bridges, plus G. Lefevre's photographic equivalents, and the detailed maps of the chromosome arms produced by C.B. and P.M. Bridges - All maps are reprinted as high-quality foldouts sturdily bound into the volume - Maps may also be purchased separately in an eight-map packet, for laboratory and student use
Author: Jessika L. Regan
Publisher: Nova Science Publishers
ISBN: 9781631175152
Category : Drosophila melanogaster
Languages : en
Pages : 0
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Book Description
Drosophila melanogaster is a species of fly in the family drosophilidae. It is generally known as the common fruit fly or vinegar fly. The use of Drosophila melanogaster in biological sciences has spanned over 100 years. Its history has a promising beginning, where D. melanogaster become one of the most popular models for studies involving modern biology. The fly is small and yellow-brown, with brick red eyes and transverse black rings across the abdomen. Although it has a relatively simple body structure, Drosophila has a number of characteristics which make it a suitable model for studying host interactions with important human pathogens. The contributors of this book discuss genes linked to species diagnostic phenotype in Drosophila; Drosophila melanogaster and how it relates to human malignancies; and Drosophila melanogaster as a host model for studying the pathogenesis and host-pathogen interaction of the Staphylococcus aureus infection.
Author: Julien Y Dutheil
Publisher:
ISBN: 9781013271403
Category : Science
Languages : en
Pages : 464
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Book Description
This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, pointers to the relevant literature, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Statistical Population Genomics aims to promote and ensure successful applications of population genomic methods to an increasing number of model systems and biological questions. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author: Costas B. Krimbas
Publisher: CRC Press
ISBN: 9780849365478
Category : Science
Languages : en
Pages : 680
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Book Description
Inversion polymorphism in Drosophila has long served as a research subject for a variety of evolutionary studies and continues to be extremely important in understanding evolutionary principles today. Until now, no single volume has ever been assembled as a summary of this work. Drosophila Inversion Polymorphism provides background information, explores new and rigorous approaches to reconstructing phylogenetic relationships from inversion variation, and discusses inversion polymorphism in the six most studied species groups. Some chapters examine general principles and conclusions, some present detailed data sets (many of which have never before been published), and others offer detailed chromosome maps for identification. The book is a one-of-a-kind source of summary discussions and data ripe for analysis. Geneticists, evolutionary biologists, biologists, and all investigators researching inversion polymorphisms should consider Drosophila Inversion Polymorphism a "must-have" volume.
Author: Dario Leister
Publisher: Springer Science & Business Media
ISBN: 1588296679
Category : Medical
Languages : en
Pages : 1195
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Book Description
Mitochondrial Genomics and Proteomics Protocols offers a broad collection of methods for studying the molecular biology, function, and features of mitochondria. In the past decade, mitochondrial research has elucidated the important influence of mitochondrial processes on integral cell processes such as apoptosis and cellular aging. This practical guide presents a wide spectrum of mitochondrial methods, each written by specialists with solid experience and intended for implementation by novice and expert researchers alike. Part I introduces major experimental model systems and discusses their specific advantages and limitations for functional analysis of mitochondria. The concise overview of general properties of mitochondrial systems is supplemented by detailed protocols for cultivation of model organisms. Parts II-VI comprise a robust collection of protocols for studying different molecular aspects of mitochondrial functions including: genetics and microbiology, biochemistry, physiology, dynamics and morphology, and functional genomics. Emphasis is placed on new and emerging topics in mitochondrial study, such as the examination of apoptotic effects, fusion and fission of mitochondria, and proteome and transcriptome analysis.
Author: Pierre Capy
Publisher: Springer Science & Business Media
ISBN: 9780792346906
Category : Science
Languages : en
Pages : 366
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Book Description
During the last 50 years, the perception oftransposable elements (TEs) has changed considerably from selfish DNA to sequences that may contribute significantly to genome function and evolution. The recent increased interest in TEs is based on the realization that they are a major genetic component (at least 10--20%) of all organisms and a major contributor to the mutation process. It is currently estimated that 70--80% of spontaneous mutations are the result of TE-mediated insertions, deletions, or chromosomal rearrangements. Thus, it seems at least plausible that TEs may playa significant role in the adaptation and evolution of natural populations and species. The ubiquity of TEs suggests that they are an old component of genomes which have been vertically transmitted through generations over evolutionary time. However, detailed analyses carried out over the last 20 years have revealed several unusual features of TE evolution: (i) TEs can be horizontally transferred between species; (ii) TE evolutionary rates can be dramatically increased by specific inactivation processes, such as the RIP (Repeat Induced Point mutation) mechanism in fungi; (iii) TEs can influence the regulation of other TEs by insertion or deletion; (iv) different classes of TEs in even distantly related species can be remarkably similar in both structure and function.
Author: Pierre Capy
Publisher: Springer Science & Business Media
ISBN: 9781402019593
Category : Medical
Languages : en
Pages : 288
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Book Description
This book brings together most of the information available concerning two species that diverged 2-3 million years ago. The objective was to try to understand why two sibling species so similar in several characteristics can be so different in others. To this end, it was crucial to confront all data from their ecology and biogeography with their behavior and DNA polymorphism. Drosophila melanogaster and Drosophila simulans are among the two sibling species for which a large set of data is available. In this book, ecologists, physiologists, geneticists, behaviorists share their data on the two sibling species, and several scenarios of evolution are put forward to explain their similarities and divergences. This is the first collection of essays of its kind. It is not the final point of the analyses of these two species since several areas remain obscure. However, the recent publication of the complete genome of D. melanogaster opens new fields for research. This will probably help us explain why D. melanogaster and D. simulans are sibling species but false friends.
Author: Carla Mucignat-Caretta
Publisher: CRC Press
ISBN: 1466553413
Category : Medical
Languages : en
Pages : 614
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Book Description
Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.
Author: M. Ashburner
Publisher: CSHL Press
ISBN: 0879698020
Category : Science
Languages : en
Pages : 128
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Book Description
This is the story of the sequencing of the fly genome as told by one of the participants, Michael Ashburner. Written in a diary-like form, half the story is told in numerous footnotes. Ashburner has written a delightful, candid, irreverent, on-the-scene tale filled with eccentric personalities all focused on a single goal. The book also contains an Epilogue that puts Drosophilaas a model system in historical context, and an Afterword that discusses the impact the genome sequence has had on the study of Drosophila.Also included are portraits by Lewis Miller of some of the principal characters. About the author:Michael Ashburner is Professor of Biology in the Department of Genetics at the University of Cambridge. By training and inclination, he is a Drosophilageneticist, although for more than a decade, he has not been where he belongs – the lab bench – but in front of computer screens. He spent six years at the European Bioinformatics Institute, first as the Institute's Research Programme Coordinator, and then as its Joint-Head. He is a Fellow of the Royal Society and an Honorary Foreign Member of the American Academy of Arts and Sciences.
Author: Stephanie Elizabeth Mohr
Publisher: Harvard University Press
ISBN: 0674984730
Category : Science
Languages : en
Pages : 273
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Book Description
A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny? Drosophila’s importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a simple but intact living system. Fly research provides answers to some of the most challenging questions in biology and biomedicine, including how cells transmit signals and form ordered structures, how we can interpret the wealth of human genome data now available, and how we can develop effective treatments for cancer, diabetes, and neurodegenerative diseases. Written by a leader in the Drosophila research community, First in Fly celebrates key insights uncovered by investigators using this model organism. Stephanie Elizabeth Mohr draws on these “first in fly” findings to introduce fundamental biological concepts gained over the last century and explore how research in the common fruit fly has expanded our understanding of human health and disease.
