The Endothelium, Part I PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Endothelium, Part I PDF full book. Access full book title The Endothelium, Part I by Michel Félétou. Download full books in PDF and EPUB format.
Author: Michel Félétou
Publisher: Biota Publishing
ISBN: 1615041249
Category : Science
Languages : en
Pages : 308
Get Book Here
Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author: Michel Félétou
Publisher: Biota Publishing
ISBN: 1615041249
Category : Science
Languages : en
Pages : 308
Get Book Here
Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
ISBN: 1615041230
Category : Science
Languages : en
Pages : 309
Get Book Here
Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author: Thomas F. Luscher
Publisher: CRC Press
ISBN: 1000083314
Category : Medical
Languages : en
Pages : 393
Get Book Here
Book Description
First published in 1990: The Endothelium: Modulator of Cardiovascular Function takes a comprehensive look at the role of the endothelium in cardiovascular control in health and disease. Experts offer detailed reviews on specific topics that address these roles of the endothelium: diffusion barrier, blood-brain barrier, regulator of capillary permeability, metabolic function (uptake and enzymatic destruction), conversion of vasoactive products, production of prostanoids, production and release of endothelium-derived relaxing factors, production of endothelium-derived contracting factors, production of coagulation factors, production of fibrinolytic factors, reticulo-endothelial function, role in atherosclerosis, and changes in function with aging and disease. This overview provides the reader with an update on the role of one of the most fascinating cells in cardiovascular biology. It focuses on the multiple functions of those cells and offers the first attempt to draw a parallel between these functions. Anyone studying the fields of physiology and pharmacology will benefit from this "must have" reference resource.
Author: Shauna Dauphinee
Publisher: Springer Science & Business Media
ISBN: 3034601689
Category : Medical
Languages : en
Pages : 243
Get Book Here
Book Description
Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.
Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
Get Book Here
Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Joseph Flynn
Publisher: Springer Science & Business Media
ISBN: 1627034900
Category : Medical
Languages : en
Pages : 597
Get Book Here
Book Description
The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
Author: David Webb
Publisher: Springer
ISBN: 9783540629436
Category : Medical
Languages : en
Pages : 154
Get Book Here
Book Description
This book reports on the current discussion of the role of endothelial function in hypertension. Topics like the role of endothelium in the regulation of vascular and blood pressure, platelet aggregation and thrombosis, lipid metabolism and desposition and the development of artherosclerosis are covered. Contributions by numerous specialists reflect the state-of-the-art of endothelial research from molecular biology to clinical application.
Author: Abel A. Garibaldi, MD
Publisher: Abel A. Garibaldi. MD
ISBN: 1737911507
Category : Antiques & Collectibles
Languages : en
Pages : 245
Get Book Here
Book Description
The presently accepted model of the circulation is based on the work of Dr. William Harvey in the 17th century. But what Dr. Harvey described was what we now call the Macrocirculation, this is, the heart, lungs, arteries, and veins. The technology at the time did not permit a study of the capillaries, the interstitial fluid, and the lymphatic system. How did oxygen and other molecules traveled from the capillary lumen to the parenchymal cells was not known. A lot of scientific knowledge has been acquired since Dr. Harvey's description. Dr. Marcello Malpighi, and Italian physician and biologist, visualized and discovered the capillaries also in the 17th Century. Claude Bernard, a French physiologist introduced the concept of the internal environment in the 19th Century, and physiologist Adolf Fick first reported a law governing mass transport through diffusive means in 1855. There was knowledge about the Lymphatic System for many years but only recently we have come to understand that it is a part of the microcirculation and the main avenue to drain cellular waste products from the cells to the circulation and out to the external environment. We can now clearly divide the circulation into a macrocirculation and a microcirculation. The former comprises the heart, lungs, arteries, and veins and has been described in detail in many volumes. The purpose of this book is to describe the microcirculation, composed of capillaries, venules, the interstitial space (the internal environment), and the lymphatic system. And to describe how important molecules travel from the capillary lumen, to the interstitial space, to the parenchymal cells, to the lymphatic system, and to the macrocirculation, to finally be expelled, in a modified form, into the external environment, which is the world we live in.
Author: Sivakumar Joghi Thatha Gowder
Publisher:
ISBN: 9535130838
Category :
Languages : en
Pages : 334
Get Book Here
Book Description
