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Author: Maria M. Picken
Publisher: Humana Press
ISBN: 3319192949
Category : Medical
Languages : en
Pages : 536
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Book Description
The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Author: Maria M. Picken
Publisher: Humana Press
ISBN: 3319192949
Category : Medical
Languages : en
Pages : 536
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Book Description
The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
Author: Gerald Litwack
Publisher: Academic Press
ISBN: 0128138157
Category : Medical
Languages : en
Pages : 740
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Book Description
Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug design who need to focus on a specific step along the pathway. This is a must have reference for researchers in endocrinology and practicing endocrinologists, but it is also ideal for biochemists, pharmacologists, biologists and students. - Serves as a valuable desk reference for researchers - Provides information on the structure of a given hormone, its receptor(s), and the pathways that become activated - Includes extensive citations to the literature that will enable the reader to dig more deeply into the effects of a given hormone
Author: James A. Carr
Publisher: Frontiers Media SA
ISBN: 2889195376
Category : Corticotropin releasing hormone
Languages : en
Pages : 116
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Book Description
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Author: Guangyu Wu
Publisher: Academic Press
ISBN: 0128029552
Category : Science
Languages : en
Pages : 351
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Book Description
G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms. - Written by future leaders in the pain field - Covers a wide range of targets - Contains provocative ideas about GPCR trafficking
Author:
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805579691
Category :
Languages : en
Pages : 117
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Book Description
Author: Giuseppe Nardulli
Publisher: World Scientific
ISBN: 9814489441
Category : Technology & Engineering
Languages : en
Pages : 293
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Book Description
In the last few years, concepts and methodologies initially developed in physics have found high applicability in many different areas. This book, a result of cross-disciplinary interaction among physicists, biologists and physicians, covers several topics where methods and approaches rooted in physics are successfully applied to analyze and to model biomedical data. Included are papers on physiological rhythms and synchronization phenomena, gene expression patterns, the immune system, decision support systems in medical science, protein folding and protein crystallography. The volume can be used as a valuable reference for graduate students and researchers at the interface of physics, biology and medicine.The proceedings have been selected for coverage in:• Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)
Author: Denis Plotnikov
Publisher: Frontiers Media SA
ISBN: 283253838X
Category : Science
Languages : en
Pages : 134
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Book Description
Author: Vickram Ramkumar
Publisher: Springer
ISBN: 3319925075
Category : Medical
Languages : en
Pages : 237
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Book Description
Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatment of hearing loss. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could produce injury to the cochlea which stimulates local and/or circulating inflammatory cells. A similar finding was observed in the cochlea following administration of the anticancer drug, cisplatin. In addition, our laboratory and others have provided a plausible mechanism by which noise or chemotherapeutic agents could stimulate the inflammatory response. Surprisingly, this mechanism involves ROS activation of transcription factors linked to inflammatory processes in the cochlea. These studies have led to the use of anti-inflammatory agents for the treatment of hearing loss. Preliminary studies targeting inflammatory cytokines appear especially promising in preclinical studies. A primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this relates to cochlear inflammation. Several different aspects of the cochlear inflammatory process will be discussed in detail, ranging from the sources of inflammatory cells, chemokines, inflammatory cytokines, and cochlea resident immune cells. Molecular pathways leading to activation of the local inflammatory process will be highlighted and treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-typmanic steroids will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.
Author:
Publisher: ScholarlyEditions
ISBN: 1481670913
Category : Medical
Languages : en
Pages : 109
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Book Description
Advances in Limbic System Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about ZZZAdditional Research. The editors have built Advances in Limbic System Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Limbic System Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Shafiqur Rahman
Publisher: Academic Press
ISBN: 0123855071
Category : Medical
Languages : en
Pages : 471
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Book Description
The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain. - Discusses new discoveries, approaches, and ideas - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields
