Author: Daniella Azulai
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 0
Book Description
The development of antibiotic resistance within microbial communities, especially in clinical settings, is currently an important public health issue. Human activity, such as the clinical overuse of therapeutic antibiotics, as well as the spread of antibiotics in the environment by anthropogenic pollution, is mainly responsible for this observed rise in resistance. Furthermore, it is predicted that as antibiotic resistance increases in bacterial populations, as will virulence: the capacity of these microbes to infect. This is due to the selection of antibiotic resistance, through widespread antibiotic use, co-selecting for virulence via shared cellular mechanisms between the two factors. We investigated the proposed link between antibiotic resistance and virulence by utilizing larval zebrafish and Pseudomonas aeruginosa of varying degrees of antibiotic resistance as a host-pathogen model. We were successful in developing a novel method to test virulence via static immersion. Using this technique, we found that there was no significant correlation between antibiotic resistance and virulence in the P. aeruginosa strains that we tested. We conclude that the developed method of static immersion will prove useful in understanding host-pathogen interactions, and can be utilized in future studies moving forward. Lastly, we suggest that further P. aeruginosa strains should be tested, as the lack of correlation between antibiotic resistance and virulence could be due to the small sample size used in this study. Investigating the connection between antibiotic resistance and virulence is crucial in understanding the impacts and consequences of society's current antibiotic use, and potentially in remediating the human activity responsible for the rise of antibiotic resistance in microbial populations.
The Co-Occurrence of Antibiotic Resistance and Virulence in the Opportunistic Pathogen Pseudomonas Aeruginosa
Author: Daniella Azulai
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 0
Book Description
The development of antibiotic resistance within microbial communities, especially in clinical settings, is currently an important public health issue. Human activity, such as the clinical overuse of therapeutic antibiotics, as well as the spread of antibiotics in the environment by anthropogenic pollution, is mainly responsible for this observed rise in resistance. Furthermore, it is predicted that as antibiotic resistance increases in bacterial populations, as will virulence: the capacity of these microbes to infect. This is due to the selection of antibiotic resistance, through widespread antibiotic use, co-selecting for virulence via shared cellular mechanisms between the two factors. We investigated the proposed link between antibiotic resistance and virulence by utilizing larval zebrafish and Pseudomonas aeruginosa of varying degrees of antibiotic resistance as a host-pathogen model. We were successful in developing a novel method to test virulence via static immersion. Using this technique, we found that there was no significant correlation between antibiotic resistance and virulence in the P. aeruginosa strains that we tested. We conclude that the developed method of static immersion will prove useful in understanding host-pathogen interactions, and can be utilized in future studies moving forward. Lastly, we suggest that further P. aeruginosa strains should be tested, as the lack of correlation between antibiotic resistance and virulence could be due to the small sample size used in this study. Investigating the connection between antibiotic resistance and virulence is crucial in understanding the impacts and consequences of society's current antibiotic use, and potentially in remediating the human activity responsible for the rise of antibiotic resistance in microbial populations.
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 0
Book Description
The development of antibiotic resistance within microbial communities, especially in clinical settings, is currently an important public health issue. Human activity, such as the clinical overuse of therapeutic antibiotics, as well as the spread of antibiotics in the environment by anthropogenic pollution, is mainly responsible for this observed rise in resistance. Furthermore, it is predicted that as antibiotic resistance increases in bacterial populations, as will virulence: the capacity of these microbes to infect. This is due to the selection of antibiotic resistance, through widespread antibiotic use, co-selecting for virulence via shared cellular mechanisms between the two factors. We investigated the proposed link between antibiotic resistance and virulence by utilizing larval zebrafish and Pseudomonas aeruginosa of varying degrees of antibiotic resistance as a host-pathogen model. We were successful in developing a novel method to test virulence via static immersion. Using this technique, we found that there was no significant correlation between antibiotic resistance and virulence in the P. aeruginosa strains that we tested. We conclude that the developed method of static immersion will prove useful in understanding host-pathogen interactions, and can be utilized in future studies moving forward. Lastly, we suggest that further P. aeruginosa strains should be tested, as the lack of correlation between antibiotic resistance and virulence could be due to the small sample size used in this study. Investigating the connection between antibiotic resistance and virulence is crucial in understanding the impacts and consequences of society's current antibiotic use, and potentially in remediating the human activity responsible for the rise of antibiotic resistance in microbial populations.
Bacterial Pathogenesis
Author:
Publisher: Academic Press
ISBN: 9780080860565
Category : Science
Languages : en
Pages : 620
Book Description
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control
Publisher: Academic Press
ISBN: 9780080860565
Category : Science
Languages : en
Pages : 620
Book Description
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control
Mechanisms of antibiotic resistance
Author: Jun Lin
Publisher: Frontiers Media SA
ISBN: 2889195260
Category : Antibiotics
Languages : en
Pages : 226
Book Description
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
Publisher: Frontiers Media SA
ISBN: 2889195260
Category : Antibiotics
Languages : en
Pages : 226
Book Description
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
Resistance of Pseudomonas Aeruginosa
Author: Michael Robert Withington Brown
Publisher: John Wiley & Sons
ISBN:
Category : Medical
Languages : en
Pages : 360
Book Description
Publisher: John Wiley & Sons
ISBN:
Category : Medical
Languages : en
Pages : 360
Book Description
Microbial Endocrinology
Author: Mark Lyte
Publisher: Springer Science & Business Media
ISBN: 1441955763
Category : Medical
Languages : en
Pages : 325
Book Description
Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.
Publisher: Springer Science & Business Media
ISBN: 1441955763
Category : Medical
Languages : en
Pages : 325
Book Description
Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.
Principles and Practice of Pediatric Infectious Diseases
Author: Sarah S. Long
Publisher: Saunders
ISBN: 9780702034688
Category : Medical
Languages : en
Pages : 1618
Book Description
"In print, online, or on your mobile device, Principles and Practice of Pediatric Infectious Disease provides the comprehensive and actionable coverage you need to understand, diagnose, and manage the ever-changing, high-risk clinical problems caused by infectious diseases in children and adolescents. With new chapters, expanded and updated coverage, and increased worldwide perspectives, this authoritative medical reference offers the latest need-to-know information in an easily-accessible, high-yield format for quick answers and fast, effective intervention!"--Publisher's website.
Publisher: Saunders
ISBN: 9780702034688
Category : Medical
Languages : en
Pages : 1618
Book Description
"In print, online, or on your mobile device, Principles and Practice of Pediatric Infectious Disease provides the comprehensive and actionable coverage you need to understand, diagnose, and manage the ever-changing, high-risk clinical problems caused by infectious diseases in children and adolescents. With new chapters, expanded and updated coverage, and increased worldwide perspectives, this authoritative medical reference offers the latest need-to-know information in an easily-accessible, high-yield format for quick answers and fast, effective intervention!"--Publisher's website.
Antimicrobial Resistance
Author: Mihai Mares
Publisher: BoD – Books on Demand
ISBN: 1839624329
Category : Medical
Languages : en
Pages : 210
Book Description
Tackling the realities of the antimicrobial resistance (AMR) situation today is no longer uncommon. Many battles have been fought in the past since the discovery of antibiotics between man and microbes. In the tussle of new antibiotic modifications, the transmission of resistant genes, both vertically and horizontally unveils yet another resistant attribute for the microbe, for it only to be faced with a more powerful, wide spectrum antibiotic; the cycle continues-and the winner is yet to be known. This book aims to provide some insight into various molecular mechanisms, agricultural mitigation methods, and the One Health applications to maybe, just maybe, tip the scales towards us.
Publisher: BoD – Books on Demand
ISBN: 1839624329
Category : Medical
Languages : en
Pages : 210
Book Description
Tackling the realities of the antimicrobial resistance (AMR) situation today is no longer uncommon. Many battles have been fought in the past since the discovery of antibiotics between man and microbes. In the tussle of new antibiotic modifications, the transmission of resistant genes, both vertically and horizontally unveils yet another resistant attribute for the microbe, for it only to be faced with a more powerful, wide spectrum antibiotic; the cycle continues-and the winner is yet to be known. This book aims to provide some insight into various molecular mechanisms, agricultural mitigation methods, and the One Health applications to maybe, just maybe, tip the scales towards us.
Olives and Olive Oil in Health and Disease Prevention
Author: Victor R Preedy
Publisher: Academic Press
ISBN: 0080922201
Category : Technology & Engineering
Languages : en
Pages : 1520
Book Description
Long used in sacred ceremonies and associated with good health, the nutritional and health promoting benefits of olives and olive oils have been proven by an ever-increasing body of science. From cardiovascular benefits to anti-microbial, anti-cancer, antioxidant activity and effects on macrophages and aptoptosis to cellular and pathophysiollogical process, olives and olive oils are proving important in many healthful ways. For example, reactive components in olive oils or olive oil by-products have now been isolated and identified. These include tyrosol, hydroxytyrosol, 3,4-dihydroxyphenyl acetic acid elenolic acid and oleuropein. Oleic acid is the main monosaturated fatty acid of olive oil. These have putative protective effects and modulate the biochemistry of a variety of cell types including those of the vascular system. Some but not all components have been characterised by their putative pharmacological properties. It is possible that usage of these aforementioned products may have beneficial application in other disease. However, in order for this cross-fertilization to take place, a comprehensive understanding of olives and olive oils is required. Finding this knowledge in a single volume provides a key resource for scientists in a variety of food an nutritional roles. Explores olives and olive oil from their general aspects to the detailed level of important micro-and micronutrients Includes coverage of various methodologies for analysis to help scientists and chemists determine the most appropriate option for their own studies, including those of olive-related compounds in other foods Relates, in a single volume resource, information for food and nutritional chemists, pharmaceutical scientists, nutritionists and dieticians Presents information in three key categories: General aspects of olives an olive oils; Nutritional, pharmacological and metabolic properties of olives and olive oil; Specific components of olive oil and their effects on tissue and body systems
Publisher: Academic Press
ISBN: 0080922201
Category : Technology & Engineering
Languages : en
Pages : 1520
Book Description
Long used in sacred ceremonies and associated with good health, the nutritional and health promoting benefits of olives and olive oils have been proven by an ever-increasing body of science. From cardiovascular benefits to anti-microbial, anti-cancer, antioxidant activity and effects on macrophages and aptoptosis to cellular and pathophysiollogical process, olives and olive oils are proving important in many healthful ways. For example, reactive components in olive oils or olive oil by-products have now been isolated and identified. These include tyrosol, hydroxytyrosol, 3,4-dihydroxyphenyl acetic acid elenolic acid and oleuropein. Oleic acid is the main monosaturated fatty acid of olive oil. These have putative protective effects and modulate the biochemistry of a variety of cell types including those of the vascular system. Some but not all components have been characterised by their putative pharmacological properties. It is possible that usage of these aforementioned products may have beneficial application in other disease. However, in order for this cross-fertilization to take place, a comprehensive understanding of olives and olive oils is required. Finding this knowledge in a single volume provides a key resource for scientists in a variety of food an nutritional roles. Explores olives and olive oil from their general aspects to the detailed level of important micro-and micronutrients Includes coverage of various methodologies for analysis to help scientists and chemists determine the most appropriate option for their own studies, including those of olive-related compounds in other foods Relates, in a single volume resource, information for food and nutritional chemists, pharmaceutical scientists, nutritionists and dieticians Presents information in three key categories: General aspects of olives an olive oils; Nutritional, pharmacological and metabolic properties of olives and olive oil; Specific components of olive oil and their effects on tissue and body systems
Pseudomonas
Author: Bernd H. A. Rehm
Publisher: John Wiley & Sons
ISBN: 3527622012
Category : Science
Languages : de
Pages : 424
Book Description
Concise and up-to-date, this handy guide fills a gap in the literature by providing the essential knowledge for everyone with an interest in the topic. The result is a comprehensive overview of the most important model organism in applied microbiology that covers basic biology, pathology and biotechnological applications.
Publisher: John Wiley & Sons
ISBN: 3527622012
Category : Science
Languages : de
Pages : 424
Book Description
Concise and up-to-date, this handy guide fills a gap in the literature by providing the essential knowledge for everyone with an interest in the topic. The result is a comprehensive overview of the most important model organism in applied microbiology that covers basic biology, pathology and biotechnological applications.
Drug resistance, global epidemiology and virulence of acinetobacter
Author: Raffaele Zarrilli
Publisher: Frontiers Media SA
ISBN: 2832518389
Category : Science
Languages : en
Pages : 183
Book Description
Publisher: Frontiers Media SA
ISBN: 2832518389
Category : Science
Languages : en
Pages : 183
Book Description