Antioxidants in Therapy and Preventive Medicine PDF Download
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Author: Ingrid Emerit
Publisher: Springer Science & Business Media
ISBN: 1468457306
Category : Medical
Languages : en
Pages : 585
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Book Description
Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications.
Author: Ingrid Emerit
Publisher: Springer Science & Business Media
ISBN: 1468457306
Category : Medical
Languages : en
Pages : 585
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Book Description
Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications.
Author: Jeffrey B. Harborne
Publisher: Springer
ISBN: 1489929096
Category : Science
Languages : en
Pages : 1218
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Book Description
The flavonoids, one of the most numerous and widespread groups of natural constituents, are important to man not only because they contribute to plant colour but also because many members (e.g. coumestrol, phloridzin, rotenone) are physiologically active. Nearly two thousand substances have been described and as a group they are universally distributed among vascular plants. Although the anthocyanins have an undisputed function as plant pigments, the raison d'etre for the more widely distributed colourless flavones and flavonols still remains a mystery. It is perhaps the challenge of discovering these yet undisc10sed functions which has caused the considerable resurgence of interest in flavonoids during the last decade. This book attempts to summarize progress that has been made in the study of these constituents since the first comprehensive monograph on the chemistry of the flavonoid compounds was published, under the editorship of T. A. Geissman, in 1962. The present volume is divided into three parts. The first section (Chapters 1-4) deals with advances in chemistry, the main emphasis being on spectral techniques to take into account the re cent successful applications of NMR and mass spectral measurements to structural identifications. Recent developments in isolation techniques and in synthesis are also covered in this section. Advances in chemical knowledge of individual c1asses of flavonoid are mentioned inter aha in later chapters of the book.
Author: Bohm
Publisher: CRC Press
ISBN: 9789057023538
Category : Science
Languages : en
Pages : 520
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Book Description
Offering a wide ranging view of this important class of plant pigments, after a brief examination of the history & literature of flavonoids, this book explores structural variation of all subclasses of flavonoids, techniques for isolation, purification, & determination of structures, chemical syntheses, biosynthesis & genetics, patterns of distribution in the plant kingdom, & uses. Lastly, the functions of flavonoids in nature are investigated, as well as ways in which these compounds may have a more direct impact upon the human race. Contents: Introduction & Historical Perspective * Structural Variation * Occurrence & Distribution of Flavonoids * Extraction, Purification, & Identification of Flavonoids * Synthesis & Interconversions of Flavonoids * Biosynthesis & Genetics * Flavonoid Functions in Nature * Human Uses of Flavonoids
Author: Chao-Hui Feng
Publisher: Nova Science Publishers
ISBN: 9781685074463
Category : Science
Languages : en
Pages : 362
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Book Description
"In this book, two of the primary sources of flavonoids, i.e. plants and fruits (oranges to be specific) are comprehensively reviewed, along with their flavonoid content and antioxidant activity (including action against COVID-19) and toxicity. Besides, a general overview of the analytical techniques for flavonoids determination in their natural sources is provided. Finally, a detailed description of flow techniques and their evolution, together with their role in the automation of the sample pretreatment and its combination with separation techniques, is also included"--
Author: Erich Grotewold
Publisher: Springer Science & Business Media
ISBN: 9780387745503
Category : Science
Languages : en
Pages : 300
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Book Description
This is the only book of its kind to provide an overview of the science of flavonoids in plants.
Author: Theodore Albert Geissman
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 688
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Book Description
Author: José Justino
Publisher: BoD – Books on Demand
ISBN: 953513423X
Category : Science
Languages : en
Pages : 486
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Book Description
Flavonoids are abundant secondary metabolites found in plants and fungi that have various roles in these organisms, including pigmentation, cell signalling, plant defence and inter-organism communication. Due to their abundance in nature, flavonoids are also important components of the human diet, and the last four decades have seen an intense study focused on the structure characterization of flavonoids and on their roles in mammal metabolism. This book reviews most of the well-established activities of flavonoids, and we also present more recent research studies on the area of flavonoids, including the chemical aspects of structure characterization of flavonoids, the biosynthesis of flavonoids in model plants as well as their role in abiotic stress situations and in agriculture, the role of flavonoids in metabolism and health and their importance in foods, from consumption to their use as bioactive components.
Author: Sumira Jan
Publisher: Elsevier
ISBN: 0081022360
Category : Science
Languages : en
Pages : 318
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Book Description
Himalayan Phytochemicals: Sustainable Options for Sourcing and Developing Bioactive Compounds provides a detailed review of the important medicinal plants which have already been discovered in the Himalayan region, outlining their discovery, activity and underlying chemistry. In addition, it supports a global shift towards sustainable sourcing of natural products from delicate ecosystems. Across the world, environmental destruction and overharvesting of medicinal plants are reducing and destroying multiple important sources and potential leads before researchers have the chance to discover, explore or synthesize them effectively. By identifying this problem and discussing its impact on the Himalayan region, Himalayan Phytochemicals: Sustainable Options for Sourcing and Developing Bioactive Compounds frames the ongoing global struggle and highlights the key factors that must be considered and addressed when working with phytochemicals from endemic plant sources. - Reviews both well-known and recently discovered plants of this region - Highlights methods for phytochemical extraction and analysis - Provides context to support a shift towards sustainable sourcing of natural products
Author: Tom Mabry
Publisher: Springer Science & Business Media
ISBN: 364288458X
Category : Medical
Languages : en
Pages : 362
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Book Description
About 1958, the late Professor R. E. ALSTON and Professor B. L. TURNER, both of the Department ofBotany, The University ofTexas at Austin, initiated a general systematic investigation ofthe legurne genus Baptisia. They found that flavonoid patterns, as revealed by two-dimensional paper chromatography, were valid criteria for the recognition of the Baptisia species and for the documentation of their numerous natural hybrids. Later, they showed that the flavonoid chemistry could be used for the analysis of gene flow among populations. At that time no attempt was made to even partially identify the flavonoids which were detected chromatographically. Neverthe1ess, it soon became apparent that the full value of the chemical data for systematic purposes required knowledge of the structures of the flavonoids. In 1962, one of us (T.J.M.) in collaboration with Drs. ALSTON and TURNER beg an the chemical analysis of the more than 60 flavonoids which had been chromatographi cally detected in the 16 Baptisia species. In the intervening years, a number of chemists and botanists, inc1uding Drs. K. BAETCKE, B. BREHM, M. CRANMER, D. HORNE, J. KAGAN, B. KROSCHEWSKY, J. MCCLURE, H. RÖSLER, and J. WALLACE, participated in the devel opment of techniques and procedures for the rapid identification of known flavonoids and in the structure determination of new flavonoids. In addition, the flavonoid chem istry of many plants other than Baptisia was investigated.
Author: H.P. Vasantha Rupasinghe
Publisher: MDPI
ISBN: 3036500006
Category : Science
Languages : en
Pages : 346
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Book Description
Flavonoids are ubiquitously present in plant-based foods and natural health products. The molecule of flavonoids is characterized by a 15-carbon skeleton of C6–C3–C6, with the different structural configuration of subclasses. The major subclasses of flavonoids with health-promotional properties are the flavanols or catechins (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavonols (e.g., quercetin glycosides from apples, berries, and onion), the flavanones (e.g., naringenin from citrus), the anthocyanins (e.g., cyanidin-3-O-glucoside from berries), and the isoflavones (e.g., genistein from soya beans). Scientific evidence has strongly shown that regular intake of dietary flavonoids in efficacious amounts reduces the risk of oxidative stress- and chronic inflammation-mediated pathogenesis of human diseases such as cardiovascular disease, certain cancers, and neurological disorders. The physiological benefits of dietary flavonoids have been demonstrated to be due to multiple mechanisms of action, including regulating redox homeostasis, epigenetic regulations, activation of survival genes and signaling pathways, regulation of mitochondrial function and bioenergetics, and modulation of inflammation response. The role of flavonoids on gut microbiota and the impact of microbial metabolites of flavonoids on optimal health has begun to unravel. The complex physiological modulations of flavonoid molecules are due to their structural diversity. However, some flavonoids are not absorbed well, and their bioavailability could be enhanced through structural modifications and applications of nanotechnology, such as encapsulation. This Special Issue consists of four review articles on flavonoids and 15 original research articles, which cover the latest findings on the role of dietary flavonoids and their derivatives in disease prevention and treatment.
