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Author: Clifford P Stanners
Publisher: CRC Press
ISBN: 0203304217
Category : Science
Languages : en
Pages : 337
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Book Description
Considers the recent explosion of knowledge about the carcinoembryonic antigen (CEA) family, which resulted from the molecular cloning of family member genes in 1986. Results indicating CEA family members upregulated in cancer could have an instrumental role in malignant transformation and metastasis, while those that are downregulated could have tumor suppressive functions are considered. Reviews, recent results, hypotheses, and clinical applications regarding a gene family that, from its widespread changes in expression in tumors at many sites, should be regarded as a "major player" in human cancer are also discussed. The normal functions such as epithelial and hematopoietic adhesion and signalling molecules are explored, and the possibly unique role of this family in evolution is introduced. This volume will be of interest to researchers in the fields of intercellular adhesion, evolution, and molecular recognition, as well as clinicians interested in the recent knowledge regarding a tumor marker commonly utilised in the clinic, and companies wishing to exploit this cancer-related family for novel commercial applications in the biomedical sphere.
Author: Clifford P Stanners
Publisher: CRC Press
ISBN: 0203304217
Category : Science
Languages : en
Pages : 337
Get Book Here
Book Description
Considers the recent explosion of knowledge about the carcinoembryonic antigen (CEA) family, which resulted from the molecular cloning of family member genes in 1986. Results indicating CEA family members upregulated in cancer could have an instrumental role in malignant transformation and metastasis, while those that are downregulated could have tumor suppressive functions are considered. Reviews, recent results, hypotheses, and clinical applications regarding a gene family that, from its widespread changes in expression in tumors at many sites, should be regarded as a "major player" in human cancer are also discussed. The normal functions such as epithelial and hematopoietic adhesion and signalling molecules are explored, and the possibly unique role of this family in evolution is introduced. This volume will be of interest to researchers in the fields of intercellular adhesion, evolution, and molecular recognition, as well as clinicians interested in the recent knowledge regarding a tumor marker commonly utilised in the clinic, and companies wishing to exploit this cancer-related family for novel commercial applications in the biomedical sphere.
Author: Cea Sunrise Person
Publisher: HarperCollins
ISBN: 1443449075
Category : Biography & Autobiography
Languages : en
Pages : 242
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Book Description
NATIONAL BESTSELLER From the author of the bestselling memoir North of Normal comes the harrowing story of a past that won’t let go, and one woman’s attempt to put her life back together after everything falls apart In her bestselling memoir North of Normal, Cea wrote with grace about her unconventional childhood—her early years living in a tipi in Alberta with her pot-smoking, free-loving counterculture family. But her struggles do not end when she leaves her family at the age of thirteen to become a model. Honest and daring, Nearly Normal reveals the many ways that Cea’s unconventional childhood continues to reverberate through the years. At the age of thirty-seven, Cea has built a life that looks like the normal one she craved as a child—husband, young son, beautiful house, enviable career. But her carefully art-directed world is about to crumble around her. As she confronts the death of her still-young mother, the disintegration of her second marriage and the demise of her business, all within a few months, she finally faces the need to look at her past to make sense of her present. The Globe and Mail says “Person’s best gifts as a writer are her memory, her knack for knowing when to dig down into the finer details of a scene, and when to pull back.” Nearly Normal chronicles the many stories Cea left untold but that needed telling. Settled into a new and much happier life after the release of her first book, she is nonetheless compelled to continue searching for answers about her enigmatic family. She discovers the value in the lessons they taught her, and the power of taking responsibility for her own choices.
Author: National Cancer Institute (U.S.)
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 744
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Book Description
Author: United States. Congress. House. Committee on Financial Services. Subcommittee on Housing and Community Opportunity
Publisher:
ISBN:
Category : Business & Economics
Languages : en
Pages : 136
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Book Description
Author: Cea Sunrise Person
Publisher: HarperCollins Publishers
ISBN: 9781443451796
Category : Biography & Autobiography
Languages : en
Pages : 416
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Book Description
“North of Normal contains so many jaw-dropping scenes it makes Jeannette Walls’ childhood (The Glass Castle) look almost conventional.” —Toronto Star In the late 1960s, Cea’s grandfather uproots his family from suburban California and moves them to the Canadian wilderness. Cea spends the first decade of her life living in a canvas tipi, surviving fierce storms, food shortages and adults more interested in their own desires than parenting a child. Knowing no other world, Cea is happy enough. But her mother is missing one crucial element: a man. When she strikes out to look for love, spinning from one boyfriend to the next, Cea is forced along for the ride—and into a harsh awakening. Shocking and heartbreaking, yet often funny, North of Normal is the story of a woman’s desire to find her normal—no matter what it takes. Cea’s journey of self-discovery and acceptance celebrates the strength we all carry within us to shape our destiny.
Author:
Publisher:
ISBN:
Category : Genomes
Languages : en
Pages : 264
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Book Description
Author: Hans G. Beger
Publisher: Springer Science & Business Media
ISBN: 3642737218
Category : Medical
Languages : en
Pages : 347
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Book Description
A variety of new cancer therapy modalities are discussed and evaluated in this book. It aims to demonstrate that the combination of classical chemo- and radiotherapy with new approaches in the field of immunotherapy can result in an improved treatment modality. Immunotherapy in this context consists of therapy with monoclonal antibodies, hematopoietic growth factors and other lymphokines. Results of early clinical trials with IL-2, GM-CSF and monoclonal antibodies against gastrointestinal tumors and melanoma are included. The progress in regional chemotherapy strategies, for example of the liver, is shown. In addition, the development of new chemotherapeutic agents with a different mode of action as well as better tolerability is presented. The use of hormones, such as LH-RH agonists, allows hormone-dependent tumors such as prostatic and breast cancer to be treated without strong adverse reactions. These recent findings give the reader insight into exciting therapeutic directions made possible by such combined, rather than single, modalities.
Author: Barbara Ferry
Publisher: BoD – Books on Demand
ISBN: 9535132490
Category : Medical
Languages : en
Pages : 338
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Book Description
The amygdala is a central component of the limbic system, which is known to play a critical role in emotional processing of learning and memory. Over these last 20 years, major advances in techniques for examining brain activity greatly helped the scientific community to determine the nature of the contribution of the amygdala to these fundamental aspects of cognition. Combined with new conceptual breakthroughs, research data obtained in animals and humans have also provided major insights into our understanding of the processes by which amygdala dysfunction contributes to various brain disorders, such as autism or Alzheimer's disease. Although the primary goal of this book is to inform experts and newcomers of some of the latest data in the field of brain structures involved in the mechanisms underlying emotional learning and memory, we hope it will also help stimulate discussion on the functional role of the amygdala and connected brain structures in these mechanisms.
Author: Chris J. Dolan
Publisher: Rowman & Littlefield
ISBN: 9780742547292
Category : Biography & Autobiography
Languages : en
Pages : 300
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Book Description
The Presidency and the Economic Policy offers an update on how economic issues have developed and evolved since the first version of the book was published in 1994. This book addresses the extent to which the president influences the domestic and global economy, manages and coordinates the economic policymaking process, and determines various economic issues on the national public policy agenda.
Author: Benoît Pelopidas
Publisher: Taylor & Francis
ISBN: 1003836178
Category : History
Languages : en
Pages : 203
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Book Description
This book offers the first non-official history of French nuclear policies which goes beyond the divide between nuclear weapons and nuclear energy policies. It addresses the sizing of France’s nuclear forces, technological assistance to countries with nuclear weapons programs, uranium prospection, nuclear testing, its health effects and protests against it, as well as plans to prevent and manage accidents in nuclear power plants. It is based on new questions and new sources from France and abroad. The chapters in this volume show how independent and interdisciplinary scholarship free from conflicts of interests can uniquely advance our understanding of nuclear history and politics. This is the case because it does not treat the categories and judgments of official discourse as neutral starting points of the analysis. This volume is based on untapped primary sources from France, the UK, the US, India, South Africa and Iran, on a new assessment of the health consequences of French nuclear testing in Polynesia thanks to a modern atmospheric particle transport code coupled with historical weather data, open-source information about radioactive debris (“mushroom”) clouds, as well as data on the composition and particle sizes of the fallout; and on new survey data about French knowledge of and attitudes towards nuclear weapons and nuclear energy. They show notably that the first generation of French nuclear forces lacked technical credibility despite reliance on outside help. Several French officials knew this, as did France's allies and adversaries. Moreover, French strategic collaborations associated to nuclear programs extended to India and South Africa; nuclear safety regulations changed fundamentally after the Cold War, and approximately 110,000 people, i.e. 90% of the French Polynesian population in the 1970s, could have received doses that would qualify them for compensation according to French law. The volume will be of interest to scholars and students of history, politics, international relations, military history, war studies, conflict and global governance. Most of the chapters in this book were originally published as a special issue in Cold War History. A few chapters were first published in the Nonproliferation Review, Diplomacy & Statecraft and Science & Global Security.
