Author: Alan B. G. Lansdown
Publisher: Royal Society of Chemistry
ISBN: 1849737193
Category : Science
Languages : en
Pages : 449
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Book Description
This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examines each of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book is an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia.
Author: Faik Atroshi
Publisher: BoD – Books on Demand
ISBN: 178923140X
Category : Medical
Languages : en
Pages : 82
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Book Description
Cancer risk factors include exposure to certain substances, which may contribute to the development of cancer. However, substances can have different levels of cancer-causing potential, and the risk of developing cancer is dependent on several factors, including individual genetic background and the amount and duration of the exposure. This book focuses on various cancer risk factors, covering numerous known, probable, and possible carcinogens; their role in carcinogenesis; mechanisms of carcinogenicity; and methods for detecting carcinogens. And due to the growing concerns over the effects that substances and environmental exposures can have on human health, the chapters also emphasize on the vital need for further topic-related research as well as development and implementation of beneficial approaches.
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Conference
Publisher:
ISBN:
Category : Carcinogens
Languages : en
Pages :
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Book Description
Author: Anuradha Mudipalli
Publisher: Springer
ISBN: 3319554484
Category : Medical
Languages : en
Pages : 235
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Book Description
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Author: Gaspar Banfalvi
Publisher: Springer Science & Business Media
ISBN: 9400704283
Category : Medical
Languages : en
Pages : 348
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Book Description
The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.
Author: Xianglin Shi
Publisher: Springer Science & Business Media
ISBN: 1461507936
Category : Science
Languages : en
Pages : 232
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Book Description
These proceedings focus on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.
Author: Ozgur Karcioglu
Publisher: BoD – Books on Demand
ISBN: 1838807853
Category : Medical
Languages : en
Pages : 130
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Book Description
Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.
Author: Gunnar F. Nordberg
Publisher: Academic Press
ISBN: 0128231386
Category : Medical
Languages : en
Pages : 1054
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Book Description
Handbook on the Toxicology of Metals, Volume II: Specific Metals, Fifth Edition provides complete coverage of 38 individual metals and their compounds. This volume is the second volume of a two-volume work which emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health. - Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems with a focus on human health effects - Includes information on sources, transport, and the transformation of metals in the environment - Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment, and prevention of 38 metallic elements and their compounds
Author: Robert H. Kretsinger
Publisher: Springer
ISBN: 9781461415329
Category : Science
Languages : en
Pages : 0
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Book Description
In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
Author: PERCIVALL. POTT
Publisher: Gale Ecco, Print Editions
ISBN: 9781379727637
Category :
Languages : en
Pages : 220
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Book Description
The 18th century was a wealth of knowledge, exploration and rapidly growing technology and expanding record-keeping made possible by advances in the printing press. In its determination to preserve the century of revolution, Gale initiated a revolution of its own: digitization of epic proportions to preserve these invaluable works in the largest archive of its kind. Now for the first time these high-quality digital copies of original 18th century manuscripts are available in print, making them highly accessible to libraries, undergraduate students, and independent scholars. Medical theory and practice of the 1700s developed rapidly, as is evidenced by the extensive collection, which includes descriptions of diseases, their conditions, and treatments. Books on science and technology, agriculture, military technology, natural philosophy, even cookbooks, are all contained here. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ British Library T007127 With a half-title, and divisional half-titles for each section. London: printed by T.J. Carnegy, for L. Hawes, W. Clarke, and R. Collins, 1775. [4], xi, [1],208p.; 8°
