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Author: Geoffrey Howard Bourne
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 408
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Book Description
Author: Geoffrey Howard Bourne
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 408
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Book Description
Author: David B. Burr
Publisher: Academic Press
ISBN: 0123914590
Category : Science
Languages : en
Pages : 390
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Book Description
This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. - Presents an in-depth overview of skeletal biology from the molecular to the organ level - Offers "refresher" level content for clinicians or researchers outside their areas of expertise - Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology
Author: John P. Bilezikian
Publisher: Academic Press
ISBN: 0080568750
Category : Medical
Languages : en
Pages : 2074
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Book Description
Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. - Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field - The essential resource for anyone involved in the study of bones and bone diseases - Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics - Readers can easily search and locate information quickly as it will be online with this new edition
Author: Geoffrey Bourne
Publisher: Elsevier
ISBN: 0323161510
Category : Science
Languages : en
Pages : 601
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Book Description
The Biochemistry and Physiology of Bone, Second Edition: Volume IV: Calcification and Physiology explores the biochemical and physiological aspects of bone calcification. It discusses the comparative physiology of bone, the organelles involved in the local mechanism of calcification, bone tracer uptake and removal, and matrix vesicles of cartilage and bone. It explains the parathyroid biosynthesis and metabolism, cellular and humoral factors in bone resorption, electrical properties of bone, circulation in relation to bone growth and metabolism, and dentin and bone formation. Organized into 12 chapters, this edition begins with an overview of noncalcifying matrix and its conversion to calcifiable matrix, impregnation of collagen, and extraskeletal calcification. The remaining chapters focus on the effects of pyrophosphate and diphosphonates on calcium metabolism and skeletal turnover, calcium kinetics in plasma, the method matrix vesicles use in initiating calcification, the chemistry of parathyroid biosynthesis and metabolism, and mammalian osteopetrosis as a model for investigating cellular and humoral factors involved in bone resorption. It also discusses the use of electron spin resonance spectrometry in studying mineralized tissues, electrical response in flexed wet bone, bone blood volume and flow, and origin and fate of bone cells. The book concludes with a chapter on the biogenesis of matrix and mineral components of dentin and bone tissues. This book is highly recommended to biochemists, cell biologists, physiologists, anatomists, orthopedists, pathologists, clinicians, biomedical engineers, graduate students, professors, and others interested in the calcification and physiology of bone.
Author: Geoffrey H. Bourne
Publisher: Elsevier
ISBN: 1483258696
Category : Science
Languages : en
Pages : 890
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Book Description
The Biochemistry and Physiology of Bone focuses on the advancements of techniques, methodologies, and approaches involved in bone studies, including general anatomy, tissues, collagen fibers, and calcification. The selection first offers information on the general anatomy and histology of bone and bone as a mechanical engineering problem. Topics include strength of healing fractures, nervous influences on bone, growth of the skull, bone strength, primary constituents of bony tissue, and types and organization of bony tissue. The text then elaborates on the ground substance of connective tissue and cartilage, organic matrix of bone, and collagen fibers of connective tissue. The publication takes a look at the ultrastructure and distribution of mineral salts in bone tissue, osteoblast, and osteoclast. Discussions focus on microscopical appearances, integration of morphological and histochemical studies, cytochemistry, distribution of inorganic salts in bone tissue, relation of collagen to its environment, and structure of collagen fibers. The publication also examines pathological calcification, effects of radiation on bone, parathyroid glands and bone, and anterior pituitary regulation of skeletal development. The selection is a dependable source of data for researchers interested in the biochemistry and physiology of bone.
Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0
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Book Description
Author: Francis H. Glorieux
Publisher: Academic Press
ISBN: 0123820405
Category : Medical
Languages : en
Pages : 885
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Book Description
Pediatric osteology, a medical specialty that has come of age, has contributed to the understanding of adult bone diseases as well. This second edition reference updates the 2003 edition with more emphasis on management as well as new and revised contributions. Thirty chapters present basic information regarding bone development, tools and techniques for evaluation (including a new chapter on radiographic imaging), and the specifics of various diseases. The three editors are affiliated as follows: Francis H. Glorieux (McGill U., Canada), John M. Pettifor (Chir Hani Baragwanath Hospital, South Africa), and Harald Juppner (Harvard Medical School, US). Academic Press is an imprint of Elsevier. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com).
Author: N. M. Hancox
Publisher: CUP Archive
ISBN: 9780521083423
Category : Medical
Languages : en
Pages : 216
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Book Description
Author: Susan Y. Smith
Publisher: Springer
ISBN: 3319561928
Category : Medical
Languages : en
Pages : 479
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Book Description
The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.
Author: United States Public Health Service
Publisher:
ISBN: 9781410219275
Category : Health & Fitness
Languages : en
Pages : 0
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Book Description
This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.
