Author: Raimo Pohjanvirta
Publisher: John Wiley & Sons
ISBN: 1118140567
Category : Science
Languages : en
Pages : 858
Get Book Here
Book Description
This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.
Author: Sangdun Choi
Publisher: Springer
ISBN: 9781493968008
Category : Medical
Languages : en
Pages : 6330
Get Book Here
Book Description
The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Author: Michael Denison
Publisher: CRC Press
ISBN: 9781439805923
Category : Medical
Languages : en
Pages : 260
Get Book Here
Book Description
Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are direc
Author: D.J. Smith
Publisher: Springer Science & Business Media
ISBN: 1461547032
Category : Science
Languages : en
Pages : 226
Get Book Here
Book Description
Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.
Author: Ulf G. Ahlborg
Publisher: Nordic Council of Ministers
ISBN: 9789291200757
Category : Science
Languages : en
Pages : 136
Get Book Here
Book Description
Author: Alvaro Puga
Publisher: CRC Press
ISBN: 9781439805978
Category : Medical
Languages : en
Pages : 604
Get Book Here
Book Description
Encouraging the incorporation of molecular biology techniques into the experimental approach to various toxicological problems, the format of the book is two-staged. Each chapter first introduces how various molecular techniques can be successfully applied to solving a specific toxicology question and proceeds to describe the techniques themselves. Also included is a discussion of the benefits and limitations of these techniques . This book will prove of value to practising researchers, but also to graduate students dealing with conceptual issues relating to molecular toxicology.
Author:
Publisher: ScholarlyEditions
ISBN: 148160242X
Category : Science
Languages : en
Pages : 125
Get Book Here
Book Description
Orphan Nuclear Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Orphan Nuclear Receptors in a concise format. The editors have built Orphan Nuclear Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Orphan Nuclear Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Orphan Nuclear Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Mostafa Z. Badr
Publisher: Springer Nature
ISBN: 3030783154
Category : Medical
Languages : en
Pages : 676
Get Book Here
Book Description
Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
Author: Dorothy May Tappenden
Publisher:
ISBN: 9781124383057
Category : Aromatic compounds
Languages : en
Pages : 153
Get Book Here
Book Description
Author: Brian J. McMillan
Publisher:
ISBN:
Category :
Languages : en
Pages : 152
Get Book Here
Book Description
