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Author: Anca Ioviţă
Publisher: Anca Ioviţă
ISBN: 8822878795
Category : Science
Languages : en
Pages : 131
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Book Description
Aging is a puzzle to solve. This process is traditionally studied in a couple of biological models like fruit flies, worms and mice. What all these species have in common is their fast aging. This is excellent for lab budgets. It is a great short-term strategy. Who has time to study species that live for decades? But lifespan differences among species are magnitudes of order larger than any lifespan variation achieved in the lab. This is the reason for which I studied countless information resources in an attempt to gather highly specialized research into one easy-to-follow book. I wanted to see the forest among the trees. I wanted to expose the aging gap between species in an easy-to-follow and logical sequence. This book is my attempt at doing just that. What are the mechanisms underlying the aging gap between species? I intentionally chose to write the answer to this question in plain English. Aging research is too important to hide it behind the closed doors of formal scientific jargon. This book could not have existed if green tea, libraries and the Internet were not invented. The amount of data I had to browse in order to keep the essential patterns is huge. Yet this book is not exhaustive. This is not a dry academic textbook. I tried to instill life in a topic that is hugely important for the extension of human lifespan. Only you can decide if I achieved this. ********* TABLE OF CONTENTS *********** Finding the Forest Among the Trees Being Reliable Counts The Mathematics of Aging The Speed of Senescence Case Study: Aging in Fish How to Estimate Chronological Age Taking Life Slowly On Temperature and Aging Dormancy The Housekeeping Problem Case Study: Aging in Turtles Intracellular Junk Case Study: Aging in Crustaceans Extracellular Junk Case Study: Protein Quality Control The Sweet Poison Are Cell Membranes the Pacemakers of Metabolism? Could Reproduction Set up the Pacemaker of Senescence? The Segregation of Somatic and Germ Cells Clonal Senescence Versus Mechanical Senescence Same Species, Different Lifespans Case Study: Eusocial Species Case Study: Parasite/Free-Living Populations Case Study: Island Versus Inland Populations Hormones as Pacemakers of Senescence Case Study: Low Hormone Levels in Long-lived Rodents Is Aging a Form of Dehydration? The Immune Pacemaker of Senescence Innate Versus Adaptive Immunity Senescent Cells Case Study: Thymic Involution in Negligible Senescence Species Reverse Engineering the Body Case Study: Why Are Sponges Potentially Immortal? Modular Growth and Aging Case Study: Youth Is Forever Gone. Unless You Are a Hydra. Or an Immortal Jellyfish Down The Neoteny Lane Case Study: Neoteny in Amphibians Case Study: Neoteny in Mammals It's All About Neoteny Does Aging Start When Growth Stops? Case Study: Indeterminate Growth in Crustaceans The Rate of Growth Case Study: Aging in Bivalves Is Telomerase The New Fountain of Youth? Case Study: Same Species, Different Telomerase Expression Telomerase Gene Therapy Case Study: Sea Urchins Perennial Plants and Their Regenerating Roots Case Study: The Bristlecone Pine Unitary Versus Colonial Organisms Cancer The Paradox of Peto Case Study: Cancer in Long-Lived Species The End Acknowledgments Bibliography
Author: Anca Ioviţă
Publisher: Anca Ioviţă
ISBN: 8822878795
Category : Science
Languages : en
Pages : 131
Get Book Here
Book Description
Aging is a puzzle to solve. This process is traditionally studied in a couple of biological models like fruit flies, worms and mice. What all these species have in common is their fast aging. This is excellent for lab budgets. It is a great short-term strategy. Who has time to study species that live for decades? But lifespan differences among species are magnitudes of order larger than any lifespan variation achieved in the lab. This is the reason for which I studied countless information resources in an attempt to gather highly specialized research into one easy-to-follow book. I wanted to see the forest among the trees. I wanted to expose the aging gap between species in an easy-to-follow and logical sequence. This book is my attempt at doing just that. What are the mechanisms underlying the aging gap between species? I intentionally chose to write the answer to this question in plain English. Aging research is too important to hide it behind the closed doors of formal scientific jargon. This book could not have existed if green tea, libraries and the Internet were not invented. The amount of data I had to browse in order to keep the essential patterns is huge. Yet this book is not exhaustive. This is not a dry academic textbook. I tried to instill life in a topic that is hugely important for the extension of human lifespan. Only you can decide if I achieved this. ********* TABLE OF CONTENTS *********** Finding the Forest Among the Trees Being Reliable Counts The Mathematics of Aging The Speed of Senescence Case Study: Aging in Fish How to Estimate Chronological Age Taking Life Slowly On Temperature and Aging Dormancy The Housekeeping Problem Case Study: Aging in Turtles Intracellular Junk Case Study: Aging in Crustaceans Extracellular Junk Case Study: Protein Quality Control The Sweet Poison Are Cell Membranes the Pacemakers of Metabolism? Could Reproduction Set up the Pacemaker of Senescence? The Segregation of Somatic and Germ Cells Clonal Senescence Versus Mechanical Senescence Same Species, Different Lifespans Case Study: Eusocial Species Case Study: Parasite/Free-Living Populations Case Study: Island Versus Inland Populations Hormones as Pacemakers of Senescence Case Study: Low Hormone Levels in Long-lived Rodents Is Aging a Form of Dehydration? The Immune Pacemaker of Senescence Innate Versus Adaptive Immunity Senescent Cells Case Study: Thymic Involution in Negligible Senescence Species Reverse Engineering the Body Case Study: Why Are Sponges Potentially Immortal? Modular Growth and Aging Case Study: Youth Is Forever Gone. Unless You Are a Hydra. Or an Immortal Jellyfish Down The Neoteny Lane Case Study: Neoteny in Amphibians Case Study: Neoteny in Mammals It's All About Neoteny Does Aging Start When Growth Stops? Case Study: Indeterminate Growth in Crustaceans The Rate of Growth Case Study: Aging in Bivalves Is Telomerase The New Fountain of Youth? Case Study: Same Species, Different Telomerase Expression Telomerase Gene Therapy Case Study: Sea Urchins Perennial Plants and Their Regenerating Roots Case Study: The Bristlecone Pine Unitary Versus Colonial Organisms Cancer The Paradox of Peto Case Study: Cancer in Long-Lived Species The End Acknowledgments Bibliography
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
ISBN: 1441906398
Category : Medical
Languages : en
Pages : 462
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Book Description
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Author: José Cordeiro
Publisher: Springer Nature
ISBN: 3031289277
Category : Technology & Engineering
Languages : en
Pages : 272
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Book Description
Is death inevitable? Until now, the history of mankind has been marked by this fatal fact. Religions, borders and progress are born from an ancient fear of death, comfort from this fear man often found only in religious paradigms. But according to José Luis Cordeiro and David Wood, the incontrovertible fact of death is no longer an absolute certainty - science and technology are preparing to tear down the final frontier: that of immortality. This accessible book provides insight into recent exponential advances in artificial intelligence, tissue regeneration, stem cell treatment, organ printing, cryopreservation, and genetic therapies that, for the first time in human history, offer a realistic chance to solve the problem of the aging of the human body. In this book, Cordeiro and Wood not only present all the major developments, initiatives, and ideas for eternal life, they also show why there are a number of good arguments for seeing death for what it is: the last undefeated disease. Enter any drugstore or bookstore, and we confronted with a mountain of nonsense concerning the aging process. Society seems obsessed with aging. That is why The Death of Death is such a refreshing delight, able to cut through the hype and reveal a balanced, authoritative, and lucid discussion of this controversial topic. It summarizes the astonishing breakthroughs made recently in revealing how science may one day conquer the aging process. Michio Kaku, theoretical physicist and author of The God Equation: The Quest for a Theory of Everything We are entering a Fantastic Voyage into life extension, crossing different bridges that will take us to indefinite life spans. The Death of Death explains clearly how we might soon reach longevity escape velocity and live long enough to live forever. Ray Kurzweil, co-author of Fantastic Voyage: Live Long Enough to Live Forever and co-founder of Singularity University The Death of Death is a truly revolutionary book. This is a visionary book that confronts us with the terrible reality of aging, and its authors are friends and connoisseurs of the subject. I believe that the authoritative and exhaustive description of this crusade that José and David make in this excellent book will accelerate this process. Forward! Aubrey de Grey, founder of LEV (Longevity Escape Velocity) Foundation and co-author of Ending Aging
Author: Jacob Jewusiak
Publisher: Cambridge University Press
ISBN: 1108585906
Category : Literary Criticism
Languages : en
Pages : 223
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Book Description
The rapid onset of dementia after an illness, the development of gray hair after a traumatic loss, the sudden appearance of a wrinkle in the brow of a spurned lover. The realist novel uses these conventions to accelerate the process of aging into a descriptive moment, writing the passage of years on the body all at once. Aging, Duration, and the English Novel argues that the formal disappearance of aging from the novel parallels the ideological pressure to identify as being young by repressing the process of growing old. The construction of aging as a shameful event that should be hidden - to improve one's chances on the job market or secure a successful marriage - corresponds to the rise of the long novel, which draws upon the temporality of the body to map progress and decline onto the plots of nineteenth-century British modernity.
Author: Katherine A. McManus
Publisher:
ISBN:
Category : Eastern hemlock
Languages : en
Pages : 248
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Book Description
Author: Frans de Waal
Publisher: Crown
ISBN: 0307407772
Category : Psychology
Languages : en
Pages : 302
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Book Description
In this thought-provoking book, the acclaimed author of Our Inner Ape examines how empathy comes naturally to a great variety of animals, including humans. Are we our brothers' keepers? Do we have an instinct for compassion? Or are we, as is often assumed, only on earth to serve our own survival and interests? By studying social behaviors in animals, such as bonding, the herd instinct, the forming of trusting alliances, expressions of consolation, and conflict resolution, Frans de Waal demonstrates that animals–and humans–are "preprogrammed to reach out." He has found that chimpanzees care for mates that are wounded by leopards, elephants offer "reassuring rumbles" to youngsters in distress, and dolphins support sick companions near the water's surface to prevent them from drowning. From day one humans have innate sensitivities to faces, bodies, and voices; we've been designed to feel for one another. De Waal's theory runs counter to the assumption that humans are inherently selfish, which can be seen in the fields of politics, law, and finance. But he cites the public's outrage at the U.S. government's lack of empathy in the wake of Hurricane Katrina as a significant shift in perspective–one that helped Barack Obama become elected and ushered in what perhaps could become an Age of Empathy. Through a better understanding of empathy's survival value in evolution, de Waal suggests, we can work together toward a more just society based on a more generous and accurate view of human nature. Written in layman's prose with a wealth of anecdotes, wry humor, and incisive intelligence, The Age of Empathy is essential reading for our embattled times. "An important and timely message about the biological roots of human kindness."—Desmond Morris, author of The Naked Ape
Author: Roger Lewin
Publisher: John Wiley & Sons
ISBN: 1405156147
Category : Science
Languages : en
Pages : 288
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Book Description
The brief length and focused coverage of Human Evolution: An Illustrated Introduction have made this best-selling textbook the ideal complement to any biology or anthropology course in which human evolution is taught. The text places human evolution in the context of humans as animals, while also showing the physical context of human evolution, including climate change and the impact of extinctions. Chapter introductions, numerous drawings and photographs, and an essential glossary all add to the accessibility of this text.The fifth edition has been thoroughly updated to include coverage of the latest discoveries and perspectives, including: · New early hominid fossils from Africa and Georgia, and their implications · New archaeological evidence from Africa on the origin of modern humans · Updated coverage of prehistoric art, including new sites · New perspectives on molecular evidence and their implications for human population history. An Instructor manual CD-ROM for this title is available. Please contact our Higher Education team at
[email protected] for more information.
Author: Jack Thornburg
Publisher: Rowman & Littlefield
ISBN: 1666958794
Category : Nature
Languages : en
Pages : 341
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Book Description
The Age of Capitalism, Consumer Culture, and the Collapse of Nature in the Anthropocene argues that the stability of post-industrial, postmodern society is threatened by the convergence of three distinct, yet interrelated, crises: environmental degradation, capitalist economic development, and the primacy of consumption and self-absorption as the basis for economic development at the expense of community and social relationships. Jack Thornburg contrasts advanced modern society with indigenous cultures in terms of nature and conceptions of the communal self. The complex nature of capitalist-oriented society has influenced how individuals conceptualize themselves. The outcome, the author contends, is a competitive society in which individuals are alienated living in uncertain times. One consequence of these crises (all of which derive from the Enlightenment and the concomitant appearance and evolution of capitalism) has been the destruction of a worldview balancing and connecting well-being with prosperity of the natural world. Money and materialism cannot buy happiness as capitalist narrative asserts. Thornburg claims that the happiness sought by individuals seeking meaning through consumption can only be realized by reintegrating nature with the human spirit.
Author: Sandra Gordon-Salant
Publisher: Springer Science & Business Media
ISBN: 1441909931
Category : Medical
Languages : en
Pages : 311
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Book Description
This volume brings together noted scientists who study presbycusis from the perspective of complementary disciplines, for a review of the current state of knowledge on the aging auditory system. Age-related hearing loss (ARHL) is one of the top three most common chronic health conditions affecting individuals aged 65 years and older. The high prevalence of age-related hearing loss compels audiologists, otolaryngologists, and auditory neuroscientists alike to understand the neural, genetic and molecular mechanisms underlying this disorder. A comprehensive understanding of these factors is needed so that effective prevention, intervention, and rehabilitative strategies can be developed to ameliorate the myriad of behavioral manifestations.
Author: Fran Saborido-Rey
Publisher: Frontiers Media SA
ISBN: 2832531091
Category : Science
Languages : en
Pages : 214
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Book Description
