Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264242244
Category :
Languages : en
Pages : 25
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Book Description
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264242244
Category :
Languages : en
Pages : 25
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Book Description
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264906
Category :
Languages : en
Pages : 24
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Book Description
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Author: Patrick Schnider
Publisher: Royal Society of Chemistry
ISBN: 1788012275
Category : Science
Languages : en
Pages : 541
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Book Description
Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.
Author: Saura C. Sahu
Publisher: John Wiley & Sons
ISBN: 1119896223
Category : Science
Languages : en
Pages : 453
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Book Description
Impact of Engineered Nanomaterials in Genomics and Epigenomics Overview of current research and technologies in nanomaterial science as applied to omics science at the single cell level Impact of Engineered Nanomaterials in Genomics and Epigenomics is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies. Combining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field. Impact of Engineered Nanomaterials in Genomics and Epigenomics includes detailed information on sample topics such as: Impact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism Toxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics Adverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity Meta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure Artificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses This comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments.
Author: Albert P. Li
Publisher: CRC Press
ISBN: 9780849388156
Category : Medical
Languages : en
Pages : 508
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Book Description
Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents.
Author: Alok Dhawan
Publisher: Academic Press
ISBN: 0128047712
Category : Science
Languages : en
Pages : 250
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Book Description
In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. - Discusses new techniques and protocols in a clear and concise manner - includes examinations of nanotoxicity, genotoxicity and carcinogenicity - Explains practical laboratory methods and the theories behind in vitro testing
Author: Chiara Frazzoli
Publisher: Frontiers Media SA
ISBN: 2889457915
Category :
Languages : en
Pages : 154
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Book Description
One Health (OH) is the conceptual and operational framework that links environment, food-producing organisms and human health. OH is a developing field, that deals with the multifaceted web of feed-backs and interactions among its components. In order to avoid “drowning into complexity”, priority issues should be identified, either for research and for risk analysis. To date OH approaches have frequently pivoted on infectious agents shared among animals and humans and the related problems, such as antibiotic resistance. Nevertheless, the OH scenarios include, and should increasingly include, environment-and-health problems. Food and environment do interact. Environment influences the living organisms that produce human food and, in the meanwhile, food production outputs influence the environmental quality; as for foods of animal origin, feed materials and practices are driving components of the environment-food interactions. In this book, we aimed at highlighting the importance of environment, chemical exposures and toxicological issues in the field of OH, as well as the need for multidisciplinary integration in order to support OH approaches into diseases prevention and health promotion.
Author: Manuel C. Peitsch
Publisher: Academic Press
ISBN: 0128209356
Category : Medical
Languages : en
Pages : 622
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Book Description
Toxicological Evaluation of Electronic Nicotine Delivery Products (ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them. This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation. - Delivers a comprehensive overview of current state of science - Offers an integrated analysis of e-cigarettes and heated tobacco products - Provides guidance for methodologies
Author: OECD
Publisher: OECD Publishing
ISBN: 9264274766
Category :
Languages : en
Pages : 60
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Book Description
Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to obtain an overview of the recent changes that ...
Author: Des W. Connell
Publisher: John Wiley & Sons
ISBN: 1119377633
Category : Science
Languages : en
Pages : 564
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Book Description
Describes the transport of pollutants through the environment and their impact on natural and human systems, fully updated to cover key topics in modern pollution science Chemistry and Toxicology of Pollution examines the interactions and adverse effects of pollution on both natural ecosystems and human health, addressing chemical, toxicological, and ecological factors at both the regional and global scale. The book is written using a conceptual framework that follows the interaction of a pollutant with the environment from distribution in the various abiotic sectors of the environment to exposure and effects on individuals and ecosystems. The authors also highlight the critical role of various socio-economic, political, and cultural aspects in achieving sustainable goals, strategies, and science-based solutions to pollution and health. This comprehensive volume covers the chemical behavior and governing principles of pollutants, their interactions with humans and ecosystems, and the methods and processes of environmental risk assessment and pollution management. Extensively revised and expanded, the second edition equips readers with the knowledge required to help lead the way towards a healthy and sustainable future. New chapters address current pollution issues such as global warming and climate change, recent advances in environmental science, the monitoring and evaluation of new and emerging pollutants, risk assessment and remediation, and innovative pollution management approaches and techniques. With in-depth material on human toxicology integrated throughout the text, Chemistry and Toxicology of Pollution: Provides an effective framework for interpreting the information produced by international, national, and local agencies Presents unifying theories and principles supported by up-to-date scientific literature Offers broad coverage of pollution science with an emphasis on North America, the UK, Europe, China, India, and Australia Discusses the similarities and differences of the impact of pollutants on the natural environment and humans Chemistry and Toxicology of Pollution, Second Edition enables readers to view pollution in its correct perspective and develop appropriate control measures. It is essential reading for scientists, academic researchers, policymakers, professionals working in industry, and advanced students in need of a clear understanding of the nature and effects of environmental pollution.
