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Author: N. V. Gerbeleu
Publisher: John Wiley & Sons
ISBN: 3527613811
Category : Science
Languages : de
Pages : 574
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Book Description
The synthesis of macrocycles is an art in itself. Template-controlled synthesis provides elegant access to fascinating macrocyclic structures. Polyazamacrocycles, crown ethers, cryptands, rotaxanes, knots -- the range of macrocyclic compounds is as broad as their potential application as molecular switches, in ion exchange, electron transfer or catalysis. This book provides authoritative information on all aspects of template-controlled macrocyclizations. It covers in depth the current state of research on template processes - novel synthetic techniques and mechanistic approaches. The critical discussion of the diverse synthetic routes includes the detailed characterization of the broad variety of macrocyclic products. References to applications of macrocyclic compounds and over 1,500 citations make this handbook an indispensable tool for chemists in academia and industry. Researchers in organic and supramolecular chemistry, biotechnology, and inorganic chemistry will find inspiration for the design, synthesis, and myriad uses of new synthetic macrocycles.
Author: N. V. Gerbeleu
Publisher: John Wiley & Sons
ISBN: 3527613811
Category : Science
Languages : de
Pages : 574
Get Book Here
Book Description
The synthesis of macrocycles is an art in itself. Template-controlled synthesis provides elegant access to fascinating macrocyclic structures. Polyazamacrocycles, crown ethers, cryptands, rotaxanes, knots -- the range of macrocyclic compounds is as broad as their potential application as molecular switches, in ion exchange, electron transfer or catalysis. This book provides authoritative information on all aspects of template-controlled macrocyclizations. It covers in depth the current state of research on template processes - novel synthetic techniques and mechanistic approaches. The critical discussion of the diverse synthetic routes includes the detailed characterization of the broad variety of macrocyclic products. References to applications of macrocyclic compounds and over 1,500 citations make this handbook an indispensable tool for chemists in academia and industry. Researchers in organic and supramolecular chemistry, biotechnology, and inorganic chemistry will find inspiration for the design, synthesis, and myriad uses of new synthetic macrocycles.
Author: Otilia Costisor
Publisher: World Scientific
ISBN: 9789812794819
Category : Science
Languages : en
Pages : 316
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Book Description
This book surveys the relatively new area of the synthesis of organic ligands when metal ions act as a template. In the last fifty years this field has undergone an explosive development, marked by a great amount of literature. The material in the book has been arranged according to the type of chemical reaction involved. In this frame, the basic principles of metal template reactions and the shape of the molecules are considered. Designed to satisfy the demands of students, young researchers doing their PhDs, and those working in the field of coordination chemistry, the book details the role of the metal ions and the specific properties of the formed complexes. Metal Mediated Template Synthesis of Ligands offers a comprehensive analysis with wide-ranging references and provides an extensive overview of research on metal-directed organic ligands over the past five decades. Contents: The Template Effect; Alkylation Reactions; Schiff Condensation; Mannich Condensation; Self Condensation of Nitriles; Self-Assembled Systems. Readership: Upper level undergraduates, graduate students, academics, researchers industrialists in inorganic, solid-state, supramolecular and organic chemistry.
Author: Eric Marsault
Publisher: John Wiley & Sons
ISBN: 1119092566
Category : Science
Languages : en
Pages : 617
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Book Description
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Author: K. Gloe
Publisher: Springer Science & Business Media
ISBN: 1402036876
Category : Science
Languages : en
Pages : 450
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Book Description
Macrocyclic Chemistry: Current Trends and Future Perspectives illustrates essential concepts in this expanding research field covering both basic and applied studies. Written by well-known experts from around the world, the topics of the chapters range from new macrocyclic architectures with different functions and self-assembly processes through to the modeling and dynamics of such systems. The content also reflects on application possibilities in analytical chemistry, separation processes, material preparation and medicine. Thus this book serves as a creative source of research strategies and methodic tools. Providing an excellent overview of the field, this book will be a valuable resource for researchers in industry and academic institutions as well as for teachers of science and graduate students. This book is devoted to the long-standing tradition of the International Symposia on Macrocyclic Chemistry (ISMC) and published to coincide with the 30th meeting, Dresden, Germany.
Author: Leonard F. Lindoy
Publisher: Cambridge University Press
ISBN: 052125261X
Category : Science
Languages : en
Pages : 281
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Book Description
This book contains an overview of complex formation by macrocyclic ligand systems. The study of macrocyclic chemistry represents a major area of activity which impinges on a range of other areas in both chemistry and biochemistry. The field has characteristically yielded many interesting and unusual compounds. The text discusses the structures and properties of macrocyclic compounds; the synthesis of macrocycles; polyether crown and related systems; metal-ion and molecular recognition (host-guest chemistry); as well as kinetic, thermodynamic and electrochemical aspects of a range of macrocyclic systems. A discussion of the different categories of naturally occurring macrocycles is also included. Specialist and non-specialist alike will find this a useful text. Apart from serving as a convenient reference for established workers in the field, it should also prove useful to new graduate students as well as to researchers from other areas who seek a general introduction to the subject. The topics discussed also provide a suitable basis for a senior undergraduate or graduate course in macrocyclic chemistry and inorganic complexes.
Author: G. W. Gokel
Publisher: Springer Science & Business Media
ISBN: 3642684513
Category : Science
Languages : en
Pages : 428
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Book Description
It seems likely that no project of this magnitude is undertaken in the absence of several motivations. This book is no exception. There are, from our perspective, at least two rational reasons for conducting this cataloging and organizational effort. The first of these is the obvious fact that a very large number of macrocyclic polyethers have now been prepared and nowhere is there a comprehensive listing of them. A number of excellent reviews have been published dealing with one or more aspects of macrocycle chemistry, but we felt a great need for a single source listing known compounds. We have, the- fore, attempted to provide such a listing to assist ourselves in keeping track as well as, we hope, helping others in this field. We also felt that there was a need for a survey of methods which have been utilized in the syntheses of these cation binders so that the novice could establish some starting point. Wherever possible, we have also attempted to point to the motivations which en gendered the various syntheses. The somewhat irrational reason which propelled us into this endeavor was the ques tioning of Charlie Morgan who often asked if one or another obscure compound had been synthesized. As often as not, we were uncertain arid now at least have a reference which, if not absolutely complete, will at least save face.
Author: Y.Z. Voloshin
Publisher: Elsevier
ISBN: 0080529178
Category : Science
Languages : en
Pages : 433
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Book Description
Clathrochelates are compounds which contain a metal ion encapsulated within a three dimensional cage of macrobicyclic ligand atoms. Within this cage the metal has unique properties and is to a great extent isolated from environmental factors. Such complexes are suitable as models of the most essential biological systems, membrane transport, electron carriers, highly selective and sensitive analytical reagents, catalysts for photochemical and redox processes, cation and anion receptors, etc. The aim of this monograph is to generalize and analyze experimental and theoretical data on clathrochelates in order to promote further research in this promising field of chemistry.Chapter 1 gives general concepts of complexes with encapsulated metal ions, discusses basic specific features of these compounds, considers and characterizes the main types of compounds with encapsulated metal ions and the main classes of clathrochelates, and includes the current nomenclature. Chapter 2 deals with the pathways of clathrochelate synthesis and the general procedures for the synthesis of macrobicyclic tris-dioximates, phosphorus-containing tris-diiminates, sepulchrates, sarcophagi-nates, and polyene and other types of clathrochelate complexes. Chapter 3 concerns studies of the electronic and spatial structure of clathrochelate complexes. In Chapter 4, the kinetics and mechanism of synthesis and decomposition reactions of macrobicyclic tris-dioximates, sarcophaginates, and sepulchrates in solution and gas phases are discussed. Chapter 5 considers the electrochemical, photochemical, and some other characteristics of clathrochelates and their applications associated with these characteristics. Finally, the practical applications of the unique properties of clathrochelates and perspectives on the synthesis of new clathrochelates are described in Chapters 6 and 7, respectively.
Author:
Publisher: John Wiley & Sons
ISBN: 0470132841
Category : Science
Languages : en
Pages : 260
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Book Description
The volumes in this continuing series provide a compilation of current techniques and ideas in inorganic synthetic chemistry. Includes inorganic polymer syntheses and preparation of important inorganic solids, syntheses used in the development of pharmacologically active inorganic compounds, small-molecule coordination complexes, and related compounds. Also contains valuable information on transition organometallic compounds including species with metal-metal cluster molecules. All syntheses presented here have been tested.
Author: Gordon Melson
Publisher: Springer Science & Business Media
ISBN: 1461329280
Category : Science
Languages : en
Pages : 676
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Book Description
Chemists have been aware of the existence of coordination compounds con taining organic macrocyclic ligands since the first part of this century ; however, only during the past few years have they expanded research into the chemistry of these compounds. The expansion was initiated in the early 1960s by the synthesis and characterization of compounds containing some new macrocyclic ligands. The synthesis of compounds which may serve as model systems for some natural products containing large rings as ligands provided the main goal for the early expansion of research effort; indeed, a recurrent theme behind much of the reported chemistry has been the analogy between synthetic macrocyclic compounds and many natural-product systems. More recently, the emphases of reported research have ranged over the whole spectrum of chemistry, and the number of publications that discuss macrocyclic chemistry has increased at a dramatic rate. The completed research has been reported in a variety of journals throughout the world but there has been no previous attempt to bring the major developments together under one cover. This book, therefore, attempts to satisfy the need for a single source in which there is both a collection and a correlation of information concerning the coordination chemistry of macrocyclic compounds. The chapters in this book discuss various aspects of macrocyclic chemistry, and while these chapters as a whole constitute an in-depth survey of the state-of the-art of the field, each chapter is written as a complete unit.
Author: Stefan Polowinski
Publisher: ChemTec Publishing
ISBN: 1895198151
Category : Biochemical templates
Languages : en
Pages : 144
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Book Description
"Template polymerization is a new field in polymer synthesis but common practice in the biosynthesis since DNA is the most popular template or matrix on which proteins are built by living species. This field is relevant to the synthesis of polymers of controlled structure but its application goes beyond the synthesis. Materials are formulated in complex mixtures always containing components which can be regarded as templates on which other materials are formed, modified, or are interacted with. In the new product development the relevance of these phenomena is controlled by the order of addition which affects probabilities and preferences of interaction. The current publication outlines mechanisms of template polymerization, polycondensation, and copolymerization. These mechanisms, illustrated with numerous examples, indicate a range of possibilities which can be encountered in materials and utilized to modify their properties. Orientation of substrates on template and their effect on modification of their reactivity and properties such as, for example, absorption of light or water are also discussed. Several chapters contain information on these studies discussed with sufficient detail to give reader comprehensive understanding of the methods used in various research laboratories and their findings."--Publisher's description.
