Technetium and Rhenium Complexes of Tripodal Ligands PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Technetium and Rhenium Complexes of Tripodal Ligands PDF full book. Access full book title Technetium and Rhenium Complexes of Tripodal Ligands by John Anthony Thomas. Download full books in PDF and EPUB format.
Author: John Anthony Thomas
Publisher:
ISBN:
Category :
Languages : en
Pages : 262
Get Book Here
Book Description
Author: John Anthony Thomas
Publisher:
ISBN:
Category :
Languages : en
Pages : 262
Get Book Here
Book Description
Author: Saul Cooper
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: Jin-Hui Wang
Publisher:
ISBN:
Category :
Languages : en
Pages : 281
Get Book Here
Book Description
Rhenium complexes play a significant role in nuclear medicine. Rhenium has been widely used as a surrogate of technetium for a long time, and the promising physical features of 186Re and 188Re, make 186/188Re-complexes promising candidates as therapeutic radiopharmaceuticals.Similarly, the interesting photoactive and photoluminescence properties of non-radioactive Re-complexes make them excellent catalysts, luminescent materials and imaging sensors.Thus, in this work, our goal was to (i) develop, using a click chemistry strategy, multidentate ligands for the stabilization of different rhenium cores [Re(CO)3]+ and [ReO]3+ (M = Re or 188Re) as well as the analogous 99mTc-cores in some examples, (ii) assess the potential of the rhenium(technetium) complexes as imaging (natRe or 99mTc) or therapeutic (188Re) agents. To do so, two rhenium(technetium) specific-chelating systems were used: a semi-rigid tripodal system in the second chapter and a pyta moiety in the third chapter, these two chelators being developed previously in our group. Thus, based on a N2O tridentate click ligand, two different studies were carried out in chapter II. In the first one, two synthetic pathways to a range of potentially N3O tetradentate ligands, designed to coordinate rhenium cores as well as their coordination behaviors towards different rhenium cores (oxidation states +I and +V), were investigated. The first radiolabeling results combined with the recent work reported by Dugave and co-workers indicated that this ligand could be a promising 99mTc-chelator for nuclear imaging applications. As perspectives to this work, the extension of the radiolabelling work using the [188ReVO]3+ core should be performed, and the in vitro stability should be tested under physiological conditions in human plasma and by cysteine exchange experiments. The second study was focused on the development of novel hypoxia-selective 99mTc radiopharmaceuticals. Our semi-rigid tripodal click framework was decorated with an appended nitro group (either a nitrobenzyl group or a metronidazole (Mtz) unit). Different positions were considered and at least only two metronidazole (Mtz)-containing ligands and one nitro group-containing ligand as well as their corresponding tricarbonyl rhenium(I) complexes were obtained and characterized, in particular by electrochemistry. The reduction potentials of NO2 group in complexes [Re(CO)3Cl(L2)] and [Re(CO)3(L6)] were similar to those of reported hypoxic imaging agents, prompting us to further investigate other properties of these complexes. Chapter III was focused on the study of AIE (aggregation-induced emission) effect in tricarbonyl Re(I) complexes, the association of this effect with the intrinsic properties of Re(I) complexes being expected to lead to very attractive compounds. To do that, we combined an organic fluorophore (PBO) which exhibits excellent stability and optical properties, with a tricarbonylrhenium(I) complex based on a pyta unit (either a 2-pyridyl-1,2,3-triazole or a 2-pyridyl-1,2,4-triazole ligands). Four compounds were studied. The X-Ray structures revealed spectacular discrepancies between the two first triazole-based complexes ReL8 and ReL9. Moreover, this study being a novel orientation in our group, this work is a great starting point for further investigations. Various organic dyes and/or structural modifications of the organic moiety will soon be considered in order to develop highly emissive rhenium(I) luminescent probes.
Author: Daniel Joshua Kramer
Publisher:
ISBN:
Category :
Languages : en
Pages : 440
Get Book Here
Book Description
(Cont.) Chapter Two: N-(2-mercaptoethyl)picolylamine (MEPAH) was studied as a potentially biologically relevant ligand for the 'fac-[M(CO)3]+" core (M = Re, 99Tc, 99mTc). To this end, the complex Re(CO)3(MEPA) was synthesized. The reaction of MEPAH with fac-[Re(CO)3(MeCN)3]+ took place over the course of seconds, showing the high affinity possessed by this ligand for the "fac-[Re(CO)3]+" core. A single crystal X-ray diffraction study was performed, confirming the nature of Re(CO)3(MEPA), a rare mononuclear rhenium(I) thiolate complex. Exploration into derivatization of the ligand backbone has afforded the analogous N-ethyl complex, Re(CO)3(MEPA-NEt). Further work has given rhenium complexes of bioconjugated ligands, whereby biologically active molecules have been tethered to the ligand framework. The high affinity of the ligand for the metal, coupled with the ease of its derivatization, implies that this ligand system is promising for the purposes of 99mTc radiopharmaceutical development. Chapter Three: The bioevaluation of 99mTc complexes of derivatives of MEPAH is described. Complexes analogous to the tricarbonylrhenium(I) complexes described in Chapter 2 were synthesized and characterized by HPLC. After confirmation of the composition of these 99mTc complexes, in vitro and in vivo studies were performed. These compounds of the "fac-[99mTc(CO)3]+' core, containing the biologically active molecules morpholine and nornicotine, were evaluated for uptake by melanoma and brain tissue, respectively, in mice.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 200
Get Book Here
Book Description
Author: Ali Barandov
Publisher:
ISBN:
Category :
Languages : en
Pages : 287
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Rhenium
Languages : en
Pages : 8
Get Book Here
Book Description
Author: Steven J. Mather
Publisher: Springer Science & Business Media
ISBN: 9400917686
Category : Medical
Languages : en
Pages : 248
Get Book Here
Book Description
Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of biochemistry, molecular biology and conventional drug design. The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. At the same time, the very latest developments in the field need to be communicated to the scientific community in order to stimulate the advancement of this exciting new direction of research.
Author: Raymond Dixon Peacock
Publisher:
ISBN:
Category : Rhenium
Languages : en
Pages : 156
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Power resources
Languages : en
Pages : 782
Get Book Here
Book Description
