Drugs Targeting B-Cells in Autoimmune Diseases PDF Download
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Author: Xavier Bosch
Publisher: Springer Science & Business Media
ISBN: 3034807066
Category : Medical
Languages : en
Pages : 300
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Book Description
This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.
Author: Xavier Bosch
Publisher: Springer Science & Business Media
ISBN: 3034807066
Category : Medical
Languages : en
Pages : 300
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Book Description
This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.
Author: Peter E. Lipsky
Publisher:
ISBN:
Category :
Languages : en
Pages : 27
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Book Description
Author: William Stohl
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805578512
Category : Medical
Languages : en
Pages : 321
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Book Description
The understanding of B cell biology has increased and expanded enormously in the last three decades. It is now known that B cells, in addition to just differentiating into antibody-secreting cells, serve many other vital functions. For example, their roles as antigen-presenting cells and cytokine-producing cells as well as effector cells and regulatory cells are well appreciated now. Indeed, the pathologic role of B cells in many autoimmune disorders may be largely autoantibody-independent. Today, the B cell is of considerable interest not only to immunologists but also to mainstream clinicians and scientists. The current volume covers the latest information on the functions of B cells in normal and disease states, and their therapeutic antagonism. Chapters cover cutting-edge topics from the basic to the clinical, including B cells in infection and autoimmunity, CD19-CD21 signal transduction complex, marginal zone B cell physiology and disease, B cell growth and differentiation, their role in rheumatoid arthritis, SLE treatment, the BAFF/APRIL system and B lymphocyte malignancies. This book is recommended reading for cellular and molecular immunologists as well as for rheumatologists, hematologists and clinical immunologists, and all those interested in human diseases in which B cells play an important contributory role.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Tomohiro Kurosaki
Publisher: Springer
ISBN: 3319261339
Category : Medical
Languages : en
Pages : 231
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Book Description
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Author: Edward L. Krawitt
Publisher: Raven Press (ID)
ISBN:
Category : Medical
Languages : en
Pages : 296
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Book Description
With contributions from over 20 specialists, this text covers the pathogenesis, immunogenetics, pathology, immunological manifestations and diagnosis, prognosis and treatment of autoimmune chronic active hepatitis, primary biliary cirrhosis and primary schlerosing cholangitis.
Author: Marinos C. Dalakas
Publisher: Butterworth-Heinemann
ISBN: 1483163040
Category : Health & Fitness
Languages : en
Pages : 362
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Book Description
Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.
Author: Tasuku Honjo
Publisher: Academic Press
ISBN: 9780123979339
Category : Science
Languages : en
Pages : 0
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Book Description
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Author: Rui Li
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Important antibody-independent pathogenic roles of B cells are emerging in autoimmune diseases including MS. The contrasting results of different treatments targeting B cells in patients (in spite of predictions of therapeutic benefit from animal models) call for a better understanding of the multiple roles that distinct human B cell subsets likely play in this illness. Cytokines expressed by B cells can be used as potential markers to define functionally distinct subsets. In spite of work carried out in mice, there remain substantial gaps in our knowledge of human cytokine-defined B cell subsets. The aim of my thesis is to better understand human cytokine-defined B cell subsets in both health and in MS, including their surface phenotype, distinct functions and the mechanisms (both external and internal) that regulate them. In the first part (Chapter 2) of my manuscript-based thesis, I identified a novel GM-CSF+ TNF[alpha]high IL-6high IL-10- effector B cell (Beff) subset that is abnormally increased, and more readily induced, in the peripheral blood of MS patients. These Beff cells strongly enhanced macrophage pro-inflammatory cytokine production through a GM-CSF-dependent mechanism. STAT5 and STAT6 were found to be important regulators of the balance between the Beff and Breg B cell subsets. Studies in patients with MS demonstrated that removal of total B cells using anti-CD20 therapy (which is very effective in limiting new MS activity) resulted in decreased myeloid cell pro-inflammatory responses. When B cells reconstituted in these patients, myeloid cells remained less inflammatory, in keeping with the lesser inflammatory profile of the reconstituting B cells. In chapter 3, I wished to investigate the impact of distinct B cell cytokine-defined subsets on T cell responses. To date, the study of B cell:T cell interactions in humans has been limited in part due to the lack of antigen specific systems to assess these interactions. I was able to establish a novel antigen-specific B-T co-culture system and used it to demonstrate that Beff cells can significantly enhance antigen-specific T cells responses to pathogens in an MHC-II restricted, CD80/CD86 and IL-6 dependent fashion. In chapter 4, I examined more closely the impact of human IL-10 expressing Breg cells on myeloid responses. I found that pro-inflammatory myeloid cell cytokine (IL-6, IL-12, TNF[alpha]) responses are significantly inhibited in co-culture with CpG-induced human Breg, an effect that was partially IL-10 dependent. CpG induced Bregs also inhibited expression of myeloid cell MHC-II and the co-stimulatory molecule CD86. Interestingly, atacicept (a TACI-Ig fusion protein) appeared to limit the induction of IL-10 expressing Bregs, providing a potential explanation for the paradoxical increase in MS disease activity seen with atacicept treatment. Together, the studies of my thesis enhance our understanding of human cytokine-defined, functionally distinct B cell subsets, both in healthy individuals and in MS patients. My results provide novel insights into the therapeutic mode of action of B cell depleting therapies in autoimmune disease, and the rational for selective targeting of distinct B cell subsets for future therapeutic approaches to both infectious and immune-mediated disease. " --
Author: Marie-Caroline Dieu-Nosjean
Publisher: Humana Press
ISBN: 9781493987085
Category : Medical
Languages : en
Pages : 289
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Book Description
This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.
