Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners PDF Download
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Author: Marianne Davies
Publisher: Springer
ISBN: 3030165507
Category : Medical
Languages : en
Pages : 122
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Book Description
This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.
Author: Marianne Davies
Publisher: Springer
ISBN: 3030165507
Category : Medical
Languages : en
Pages : 122
Get Book Here
Book Description
This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.
Author: Robert C. Bast, Jr.
Publisher: John Wiley & Sons
ISBN: 1118934695
Category : Medical
Languages : en
Pages : 2003
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Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Manzoor Ahmad Mir
Publisher: Academic Press
ISBN: 0323961371
Category : Science
Languages : en
Pages : 262
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Book Description
Combinational Therapy in Triple Negative Breast Cancer discusses TNBC at the molecular level from a holistic approach, focusing on combinational strategies targeting various pathways involved in this specific cancer type. Using a monotherapy for the treatment of cancer, especially high-grade tumors like TNBC, is mostly worthless due to the inherent genetic instability of tumor cells to develop intrinsic and acquired resistance. Combination therapy presents more, or at least the same, effectiveness with lower doses of every single agent and decreases the likelihood of chemoresistance, making it essential to understand for multiple therapy options. The book is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of combinational therapies to treat triple negative breast cancer. - Presents up-to-date and cutting-edge knowledge of Triple negative breast cancer (TNBC) biology, clinical aspects and treatment options - Discusses novel targets and pathways involved in TNBC - Provides insights and approaches for future research on TNBC
Author: Robert Brian Cameron
Publisher: World Scientific
ISBN: 9814725536
Category : Medical
Languages : en
Pages : 1035
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Book Description
Modern Thoracic Oncology is the first comprehensive publication on thoracic oncology. Contributors who are world experts have authored concise, relevant and current topics in this field. Whether one desires information regarding lung cancer screening, esophageal cancer staging, mutational analysis, targeted therapies, stereotactic ablative radiation with real-time imaging, minimally-invasive and robotic surgery, combination immunotherapy, microwave/cryoablation, or methods of early cancer detection, this set of three volumes, encompass all of the latest information in the field of thoracic oncology. A rapidly advancing knowledgebase has led to dramatic improvements in individualized or 'personalized' care of patients. However, the myriad of rapid changes has also made it more challenging for thoracic oncologists to comprehend and incorporate these improvements into their daily practice. This staggering and rapid change requires a comprehensive thoracic oncology publication designed to keep clinicians, including pulmonologists, pathologists, radiologists, surgeons, medical oncologists, radiation oncologists and gastroenterologists, well-informed and up-to-date. To meet such needs and to ensure that all areas of thoracic oncology are covered indepth, Modern Thoracic Oncology is published in three volumes.Volume 1 entitled General Principles of Thoracic Oncology provides a comprehensive introduction to thoracic oncology. Principles of thoracic oncology care are discussed in detail and include topics such as thoracic anatomy and embryology, medical evaluation of cancer patients, appropriate imaging modalities with a specific discussion of lung cancer screening, and the basic principles underlying the various treatment modalities. Volume 2 entitled Trachea, Lung, and Pleura addresses lung cancer, one of the most common and deadliest malignancies in the world, as well as two relatively rare respiratory tumors. Volume 3 entitled Esophagus, Mediastinum, Chest Wall and Diaphragm covers esophageal cancer, one of the most rapidly growing malignancies in the world and which still poses significant challenges to thoracic oncologists. Esophageal squamous cell tumors are discussed by experts from Asia where this disease is endemic and adenocarcinoma of the esophagus is detailed by oncologists in the West who face this challenge on a daily basis.
Author: Manfred Dietel
Publisher: Springer
ISBN: 9783642432439
Category : Medical
Languages : en
Pages : 0
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Book Description
From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
Author: Donna D. Ignatavicius
Publisher: Elsevier Health Sciences
ISBN: 1437728014
Category : Medical
Languages : en
Pages : 1905
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Book Description
Using a uniquely collaborative and reader-friendly approach, expert authors Donna D. Ignatavicius and M. Linda Workman cover all the latest trends, evidence-based treatment guidelines, and additional updated information needed for safe clinical practice in medical-surgical nursing. This seventh edition features an expanded emphasis on patient safety and NCLEX? Examination preparation, new ties to the QSEN priorities for patient safety, and a greater alignment with the language and focus of clinical practice. A new chapter on evidence-based practice and a wealth of effective online learning tools help solidify your mastery of medical-surgical nursing.
Author: Donna D. Ignatavicius
Publisher: Elsevier Health Sciences
ISBN: 0323293441
Category : Medical
Languages : en
Pages : 1905
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Book Description
Using a uniquely collaborative and reader-friendly approach, expert authors Donna D. Ignatavicius and M. Linda Workman cover all the latest trends, evidence-based treatment guidelines, and additional updated information needed for safe clinical practice in medical-surgical nursing. This seventh edition features an expanded emphasis on patient safety and NCLEX® Examination preparation, new ties to the QSEN priorities for patient safety, and a greater alignment with the language and focus of clinical practice. A new chapter on evidence-based practice and a wealth of effective online learning tools help solidify your mastery of medical-surgical nursing. UNIQUE! Collaborative approach presents all medical, surgical, nursing, and other interventions through the lens of the nursing process. Reader-friendly, direct writing style makes this one of the most readable medical-surgical nursing textbooks available. UNIQUE! Cutting-edge focus on the latest trends in nursing practice and nursing education prepares you for both today and tomorrow’s nursing practice. UNIQUE! Integrated tools for NCLEX preparation get you ready for your licensure examination. Chapter-opening Learning Outcomes are linked to Self-Assessment Questions for the NCLEX Examination on the Evolve website. Unique chapter-ending Get Ready for the NCLEX Examination! sections include Key Points organized by NCLEX Client Needs Categories. UNIQUE! Focus on nursing concepts helps bridge the gap between the concepts learned in Nursing Fundamentals, and disorders content learned in the medical-surgical nursing course. UNIQUE! Emphasis on clinical decision-making teaches you to apply concepts to true-to-life clinical situations. UNIQUE! Concentration on the core body of knowledge for the RN level of medical-surgical nursing practice focuses your attention on "need-to-know" content to pass the NCLEX Examination and practice safely as a beginning nurse. Rich array of effective learning aids includes: Best Practice for Patient Safety & Quality Care Best Practice for Emergency Care Patient and Family Education: Preparing for Self-Management Nursing Focus on the Older Adult Home Care Assessment Focused Assessment Common Examples of Drug Therapy Evidence-Based Practice Concept Maps Laboratory Profiles Assessment Using Gordon’s Functional Health Patterns
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309466113
Category : Medical
Languages : en
Pages : 103
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Book Description
Palliative care is the interdisciplinary specialty focused on improving quality of life for people with serious illness and their families. This interdisciplinary care is provided by doctors, nurses, social workers, chaplains and others who work together with the patient's other doctors to provide an extra layer of support. Such care is appropriate for people at any age and at any stage in a serious illness, and can be provided together with curative treatment to address clinical, emotional, psychosocial and spiritual concerns of the patient and their family. To better understand how the principles of palliative care can be integrated into the overall provision of care and services to those facing serious illness, the Roundtable on Quality Care for People with Serious Illness held a public workshop in April 2017. This publication summarizes the presentations and discussions from the workshop.
Author: David O'Halloran
Publisher: Elsevier Health Sciences
ISBN: 0323881238
Category : Medical
Languages : en
Pages : 189
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Book Description
This new book covers the basics of oncology for all practitioners who are likely to provide health care to cancer patients, especially those who do not have an oncology or medical background. Cancer educator David O'Halloran provides a unique insight by bridging the gap between normal anatomy and what happens when cancer develops. Information is provided using a layered approach, starting with simple concepts of general cancer biology and moving through to more complicated aspects of specific tumour sites and cancer treatment. Easy to read and follow, Oncology: An Introduction for Nurses & Healthcare Professionals is written in such a way that non-specialist readers will quickly understand complex terminology and concepts, making them relatable and understandable for experienced and junior nurses alike. - Logical and easy-to-follow approach - Accessible language throughout – does not assume a prior level of knowledge - Explains cancer terminology for non-experts - Takes a graded approach to information to help learning - Provides an understanding of cancer and how it progresses, how to link anatomy to the staging of cancer, and how to explain how modern cancer treatments work - Invaluable in helping explain conditions and treatment to patients and families - Self-assessment exercises throughout help test learning
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 030913398X
Category : Medical
Languages : en
Pages : 340
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Book Description
Cancer is low or absent on the health agendas of low- and middle-income countries (LMCs) despite the fact that more people die from cancer in these countries than from AIDS and malaria combined. International health organizations, bilateral aid agencies, and major foundations—which are instrumental in setting health priorities—also have largely ignored cancer in these countries. This book identifies feasible, affordable steps for LMCs and their international partners to begin to reduce the cancer burden for current and future generations. Stemming the growth of cigarette smoking tops the list to prevent cancer and all the other major chronic diseases. Other priorities include infant vaccination against the hepatitis B virus to prevent liver cancers and vaccination to prevent cervical cancer. Developing and increasing capacity for cancer screening and treatment of highly curable cancers (including most childhood malignancies) can be accomplished using "resource-level appropriateness" as a guide. And there are ways to make inexpensive oral morphine available to ease the pain of the many who will still die from cancer.
