Synthesis of Some 1,5-disubstituted Tetrazoles PDF Download
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Author: Bernard Richard Schaafsma
Publisher:
ISBN:
Category :
Languages : en
Pages : 86
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Book Description
Author: Bernard Richard Schaafsma
Publisher:
ISBN:
Category :
Languages : en
Pages : 86
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Book Description
Author: Frances Gertrude Fallon
Publisher:
ISBN:
Category : Organic compounds
Languages : en
Pages : 384
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Book Description
Author: Robert Larry Shone
Publisher:
ISBN:
Category : Growth (Plants)
Languages : en
Pages : 82
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Author: Willard Jason Haak
Publisher:
ISBN:
Category : Iminotetrazolines
Languages : en
Pages : 100
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Book Description
![Expedient Synthesis of Tetrazoles Using [2 + 3] Dipolar Cycloadditions PDF](https://books.google.com/books/content/images/frontcover/XtK6tAEACAAJ?fife=w80-h100)
Author: Zachary Paul Demko
Publisher:
ISBN: 9780493613796
Category : Organic compounds
Languages : en
Pages : 250
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Book Description
Several general routes to various classes of tetrazoles, including 1 H -tetrazoles, fused bicyclic tetrazoles, 5-sulfonyl tetrazoles, 5-heterotetrazoles, and 5-acyl tetrazoles have been developed. A convenient and general route to transform nitriles to 1H -tetrazoles using sodium azide, zinc salts as catalysts, and refluxing water as a solvent is discussed. Yields are high, and isolation procedures are extremely simple. This method is shown to apply especially well to the transformation of [alpha]-amino nitriles to [alpha]-amino tetrazoles, the pharmaceutically important tetrazole analogs of [alpha]-amino acids. When the [alpha]-amino nitriles are Cbz protected, yields are at least 90%. Enantiomeric purity of starting materials is largely preserved. Fused 5-heterotetrazole ring systems are synthesized in high yield via intramolecular [2+3] cycloadditions of organic azides and heteroatom substituted nitriles. Cyanates, thiocyanates and cyanamides are all competent dipolarophiles in the reaction. A variety of scaffolds are tolerated when the new enclosed ring is 5- or 6-membered. Sulfonyl cyanides are shown to react very cleanly with azides when heated, neat, to give 5-sulfonyl tetrazoles. When unhindered alkyl azides are used as the dipole, yields are quantitative. The resulting tetrazoles are readily functionalized by SN Ar chemistry to give a variety of 1,5-disubstituted tetrazoles. In a similar vein, acyl cyanides are shown to react well with azides when heated, neat, to give 5-acyl tetrazoles. Isolation is simple, and yields are generally above 90%. When p-nitrocyanoformate is used as the dipolarophile, the resulting tetrazoles are easily functionalizable to give a range of 1,5-disubstituted acyltetrazoles.
Author: Michael Decker
Publisher: Elsevier
ISBN: 0081011180
Category : Science
Languages : en
Pages : 354
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Book Description
Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. - Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes - Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied - Compares the advantages and disadvantages of these compounds - Includes the very latest developments, such as photoactivatable and photo-responsive drugs
Author: Joseph M. Lesser
Publisher:
ISBN:
Category :
Languages : en
Pages : 198
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Author: James Pennington Settle
Publisher:
ISBN:
Category : Dioxane
Languages : en
Pages : 94
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Book Description
Author:
Publisher: Academic Press
ISBN: 0128211520
Category : Science
Languages : en
Pages : 432
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Book Description
Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Optical Imaging and Conjugation, Volume 639, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Fluorogenic detection of protein aggregates in live cells using the AggTag method, Synthesis and Application of Ratiometric Probes for Hydrogen Peroxide Detection, Chemical Tools for Multicolor Protein FRET with Tryptophan, Fluorescing Isofunctional Ribonucleosides for Adenosine Deaminase Activity and Inhibition, Temporal profiling establishes a dynamic S-palmitoylation cycle, Solvation-guided design of fluorescent probes for discrimination of amyloids, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Author: Benjamin F. Cravatt
Publisher: Springer
ISBN: 3030111431
Category : Medical
Languages : en
Pages : 420
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Book Description
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
