Author:
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Category :
Languages : en
Pages : 0
Book Description
Synthesis and testing of novel porphyrins for use in photodynamic therapy
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Synthesis and Testing of Novel Porphyrins for Use in Photodynamic Therapy
Author: Alexandra M. P. Santana Sorensen
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Synthesis and Studies of Novel Porphyrins and Their Potential Use in Photodynamic Therapy
Author: Telmo L. C. Figueiredo
Publisher:
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Languages : en
Pages :
Book Description
Publisher:
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Category :
Languages : en
Pages :
Book Description
The Design, Synthesis and Biological Testing of Porphyrins as Photodynamic Therapy Agents
Author: Fargol Taba
Publisher:
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Category : Photochemotherapy
Languages : en
Pages : 488
Book Description
Publisher:
ISBN:
Category : Photochemotherapy
Languages : en
Pages : 488
Book Description
Synthesis and Biological Evaluation of Porphyrins for Use in Photodynamic Therapy
Author: Kathryn Wynne Woodburn
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 334
Book Description
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 334
Book Description
Design, Synthesis and Evaluation of Core and Substituent Modified Porphyrins as Novel Second Generation Photodynamic Therapy Sensitizers
Author: Corey E. Stilts
Publisher:
ISBN:
Category :
Languages : en
Pages : 262
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 262
Book Description
Synthesis of a Novel Water-soluble Porphyrin Derivative for Use as a Potential Phototherapeutic Cancer Treatment
Author: Joseph Earl Bradshaw
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Photodynamic therapy (PDT) agents are light-activated materials used for localized disease treatment. Porphyrins are classic representations of photosensitive agents. Identified by their large, planar molecular structure, porphyrins are centrally composed of four pyrrole rings. Through this project, the starting material, H2TPPC, a tetra-carboxylic acid porphyrin, was first synthesized and later modified through the addition of the amine, morpholin-2-ylmethanol. This multi-step synthesis resulted in the highly water-soluble porphyrin product H2TPP-MorphMeOH. Following this synthesis, the compound was purified using liquid chromatography, and then structurally identified and classified using infrared (IR), nuclear magnetic resonance (NMR), and UV-Vis spectroscopies. Lastly, to determine its utility as a potential PDT agent, the cytotoxicity of H2TPP-MorphMeOH was determined using an MTT assay on MDA-MB-231 triple negative breast cancer cells comparing exposure and absence of white light.
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Photodynamic therapy (PDT) agents are light-activated materials used for localized disease treatment. Porphyrins are classic representations of photosensitive agents. Identified by their large, planar molecular structure, porphyrins are centrally composed of four pyrrole rings. Through this project, the starting material, H2TPPC, a tetra-carboxylic acid porphyrin, was first synthesized and later modified through the addition of the amine, morpholin-2-ylmethanol. This multi-step synthesis resulted in the highly water-soluble porphyrin product H2TPP-MorphMeOH. Following this synthesis, the compound was purified using liquid chromatography, and then structurally identified and classified using infrared (IR), nuclear magnetic resonance (NMR), and UV-Vis spectroscopies. Lastly, to determine its utility as a potential PDT agent, the cytotoxicity of H2TPP-MorphMeOH was determined using an MTT assay on MDA-MB-231 triple negative breast cancer cells comparing exposure and absence of white light.
Photosensitization of Porphyrins and Phthalocyanines
Author: Ichiro Okura
Publisher: CRC Press
ISBN: 1351590545
Category : Medical
Languages : en
Pages : 269
Book Description
Photosensitization of Porphyrins and Phthalocyanines covers the scentific background to porphyrins and phthalocyanines, and applications of the compounds, especially for the application for photosensitization. It also has a review of advances in research and applications in this field.
Publisher: CRC Press
ISBN: 1351590545
Category : Medical
Languages : en
Pages : 269
Book Description
Photosensitization of Porphyrins and Phthalocyanines covers the scentific background to porphyrins and phthalocyanines, and applications of the compounds, especially for the application for photosensitization. It also has a review of advances in research and applications in this field.
The Porphyrin Handbook: Medical aspects of porphyrins
Author:
Publisher:
ISBN:
Category : Porphyrins
Languages : en
Pages : 396
Book Description
Publisher:
ISBN:
Category : Porphyrins
Languages : en
Pages : 396
Book Description
Methods in Porphyrin Photosensitization
Author: David Kessel
Publisher: Springer Science & Business Media
ISBN: 1461321654
Category : Science
Languages : en
Pages : 346
Book Description
The use of porphyrins for localization and photodynamic therapy of neoplastic disease has been the topic of several international symposia, reviews and books during the preceeding five years. The literature on this topic has continued to grow, as have numbers of presentations at national and international meetings relating to photobiology, chemistry, and lasers. In this volume, it is the intention of the editor to provide both information on current research projects, and detailed methodology used in such investigations. A bibliography on the subjects of porphyrin localization and therapy is included. The manuscripts contained in this volume are based on reports given at a Porphyrin Photosensitization Workshop which was held in Philadel phia, July 6-7, 1984. This Workshop was supported by NIH grant CA 36746, together with funds from the Fogarty International Center. Authors were requested to update their contributions to provide a summary of progress to mid 1985. Manuscripts containing material not presented in Philadelphia are also included, notably a series of articles describ ing current clinical and pre-clinical results from China. Since the Philadelphia Workshop, a meeting was held in Alghero, Sardinia (May, 1985), and additional conferences are now being planned; this attests to the continued interest in photodynamic therapy involving porphyrin photo sensitization.
Publisher: Springer Science & Business Media
ISBN: 1461321654
Category : Science
Languages : en
Pages : 346
Book Description
The use of porphyrins for localization and photodynamic therapy of neoplastic disease has been the topic of several international symposia, reviews and books during the preceeding five years. The literature on this topic has continued to grow, as have numbers of presentations at national and international meetings relating to photobiology, chemistry, and lasers. In this volume, it is the intention of the editor to provide both information on current research projects, and detailed methodology used in such investigations. A bibliography on the subjects of porphyrin localization and therapy is included. The manuscripts contained in this volume are based on reports given at a Porphyrin Photosensitization Workshop which was held in Philadel phia, July 6-7, 1984. This Workshop was supported by NIH grant CA 36746, together with funds from the Fogarty International Center. Authors were requested to update their contributions to provide a summary of progress to mid 1985. Manuscripts containing material not presented in Philadelphia are also included, notably a series of articles describ ing current clinical and pre-clinical results from China. Since the Philadelphia Workshop, a meeting was held in Alghero, Sardinia (May, 1985), and additional conferences are now being planned; this attests to the continued interest in photodynamic therapy involving porphyrin photo sensitization.