Synthesis and Characterization of Silica Hydride-based Pentynoic Acid Stationary Phase PDF Download
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Author: Nasrin Syed
Publisher:
ISBN:
Category : High performance liquid chromatography
Languages : en
Pages : 92
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Book Description
High performance liquid chromatography is an important analytical technique used for the separation and identification of components in a mixture. The aim of this research project was to synthesize and characterize a silica hydride-based pentynoic acid stationary phase. Analytical techniques like elemental analysis and diffuse reflectance infrared fourier transform spectroscopy (DRIFT) were used to confirm the success of bonding between silica hydride and pentynoic acid moiety. The pentynoic acid Si-H column allows for retention of both polar and non-polar compounds by carefully selecting the concentration ratio of organic solvent to water in the mobile phase. The characterization of the column was done using a series of polar and nonpolar compounds by studying their aqueous normal-phase and reversed-phase chromatographic behavior. The interactions between the stationary phase and the analyte include both hydrophobic and ionic/electrostatic interactions. The effect of varying the pH of the mobile phase on retention time was examined. The column's ability to run under reverse and aqueous normal phase conditions provides unmatched versatility compared to type-B silica columns.
Author: Nasrin Syed
Publisher:
ISBN:
Category : High performance liquid chromatography
Languages : en
Pages : 92
Get Book Here
Book Description
High performance liquid chromatography is an important analytical technique used for the separation and identification of components in a mixture. The aim of this research project was to synthesize and characterize a silica hydride-based pentynoic acid stationary phase. Analytical techniques like elemental analysis and diffuse reflectance infrared fourier transform spectroscopy (DRIFT) were used to confirm the success of bonding between silica hydride and pentynoic acid moiety. The pentynoic acid Si-H column allows for retention of both polar and non-polar compounds by carefully selecting the concentration ratio of organic solvent to water in the mobile phase. The characterization of the column was done using a series of polar and nonpolar compounds by studying their aqueous normal-phase and reversed-phase chromatographic behavior. The interactions between the stationary phase and the analyte include both hydrophobic and ionic/electrostatic interactions. The effect of varying the pH of the mobile phase on retention time was examined. The column's ability to run under reverse and aqueous normal phase conditions provides unmatched versatility compared to type-B silica columns.
Author: Prema Gangadhara
Publisher:
ISBN:
Category : High performance liquid chromatography
Languages : en
Pages : 136
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Book Description
The silanization/hydrosilation process was developed to overcome some of the drawbacks associated with the use of organosilane reagents for the synthesis of high pressure liquid chromatography (HPLC) stationary phases. The first step is called silanization, in which silica or other oxides react with triethoxysilane (TES), resulting in the formation of a silica hydride surface. Endcapping the stationary phase using trimethylchlorosilane (TMCS) and hexamethyldisilazane (HMDS) eliminates the unreacted and accessible silanols on the silica hydride intermediate. This research employed the modification of bare silica to silica hydride via silanization. Endcapping after silanization eliminated accessible and unreacted silanols. Endcapping was confirmed by using diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy. The stationary phase was characterized for its hydrophobicity and silanophilicity properties. The effectiveness of the stationary phase was determined for its aqueous normal phase and reversed-phase chromatographic behavior. The performance was compared with the performance of C8 silica hydride column under similar conditions. This research confirmed that endcapped columns could be used in the aqueous normal phase and reversed-phase modes. Endcapping increased the hydrophobicity of the surface, which in turn increased the efficiency of separation for nonpolar solutes.
Author: Kavita Vipool Prajapati
Publisher:
ISBN:
Category : Amino acids
Languages : en
Pages : 178
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Book Description
Silica-based fluorinated bonded stationary phases have shown enhanced selectivity with altered elution orders for molecules differing in hydrophobicity and hydrophilicity in comparison with C8 and C18 reversed phase columns. Hence, two novel silica hydride-based fluorinated bonded phases have been synthesized using a hydrosilation procedure to exploit fluorine-based unique selectivity for polar basic metabolites. Bonded moieties have been characterized by elemental and spectral analyses. Silica hydride-based aqueous normal phase (ANP) chromatography has retention behavior similar to normal phase chromatography, except for the use of water as a part of the binary solvent (>60 % acetonitrile : water). In ANP, a higher percentile of nonpolar mobile phase shows increased retention for acids and bases, and nonpolar solutes can also be retained as in reversed phase chromatography (RPC). The synergistic effects of fluorinated phases' altered selectivity and aqueous normal phase retentivity have been explored for small polar metabolites using high performance liquid chromatography (HPLC) coupled with several detectors. Hydride-based fluorinated stationary phases showed good stability and remarkable reproducibility in retention time with %RSD
Author: Kamalakannan Kailasam
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Ali Abdali
Publisher:
ISBN: 9783954047048
Category :
Languages : en
Pages : 122
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Book Description
Author: Deogratius Titus Maiga
Publisher:
ISBN:
Category : Infrared spectroscopy
Languages : en
Pages : 150
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Book Description
Author: Derek H. R. Barton
Publisher: Pergamon
ISBN:
Category : Chemistry, Organic
Languages : en
Pages : 552
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Book Description
R.B. Woodward, Professor of Science at Harvard University, who died in July 1979, was generally considered to be the greatest organic chemist of modern times. He was one of the founders of Tetrahedron and Tetrahedron Letters and this volume, containing papers from over 50 of the world's leading organic chemists, is dedicated to his memory. The contents cover all areas of modern organic chemistry and therefore present a synopsis of current research in this area of science.
Author: Anatolii D. Pomogailo
Publisher: Springer Science & Business Media
ISBN: 3642105742
Category : Technology & Engineering
Languages : en
Pages : 311
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Book Description
Data on the synthesis and physicochemical studies of salts of mono- or dibasic unsaturated carboxylic acids and macromolecular metal carboxylates are generalised and described systematically in this monograph. The structures and properties of the COO group in various compounds and characteristic features of the structures of carboxylate are analysed. The main routes and kinetics of polymerisation transformations of unsaturated metal carboxylates are considered. The attention is focused on the effect of the metal ion on the monomer reactivity and the polymer morphology and structure. The possibility of stereochemical control of radical polymerisation of unsaturated metal carboxylates is demonstrated. The electronic, magnetic, optical, absorption and thermal properties of metal (co)polymers and nanocomposites and their main applications are also considered.
Author: Bradley D. Fahlman
Publisher: Springer
ISBN: 9402412557
Category : Technology & Engineering
Languages : en
Pages : 817
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Book Description
The 3rd edition of this successful textbook continues to build on the strengths that were recognized by a 2008 Textbook Excellence Award from the Text and Academic Authors Association (TAA). Materials Chemistry addresses inorganic-, organic-, and nano-based materials from a structure vs. property treatment, providing a suitable breadth and depth coverage of the rapidly evolving materials field — in a concise format. The 3rd edition offers significant updates throughout, with expanded sections on sustainability, energy storage, metal-organic frameworks, solid electrolytes, solvothermal/microwave syntheses, integrated circuits, and nanotoxicity. Most appropriate for Junior/Senior undergraduate students, as well as first-year graduate students in chemistry, physics, or engineering fields, Materials Chemistry may also serve as a valuable reference to industrial researchers. Each chapter concludes with a section that describes important materials applications, and an updated list of thought-provoking questions.
Author: Stefan Bräse
Publisher: John Wiley & Sons
ISBN: 0470682523
Category : Science
Languages : en
Pages : 536
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Book Description
Most current state-of-the-art overview of this important class of compounds, encompassing many new and emerging applications The number of articles on organic azides continues to increase tremendously; on average, there are more than 1000 new publications a year Covers basic chemistry as well as state-of-the-art applications in life science and materials science World-ranked authors describe their own research in the wider context of azide chemistry Includes a chapter on safe synthesis and handling (azides can decompose explosively)
