Surrogate Tissue Analysis PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Surrogate Tissue Analysis PDF full book. Access full book title Surrogate Tissue Analysis by Michael E. Burczynski. Download full books in PDF and EPUB format.
Author: Michael E. Burczynski
Publisher: CRC Press
ISBN: 1420038095
Category : Medical
Languages : en
Pages : 329
Get Book
Book Description
Both an introduction and a fundamental reference, this book explores how to apply genomic, proteomic, and metabolomic technologies to surrogate tissue analysis. It reviews fundamental analytical issues and actual initial results generated using these technologies. The book covers transcriptional profiling (genomics), protein profiling (proteomics), methylation profiling (epigenomics), metabolite profiling (metabolomics) and additional biomarker identification methods that can be applied to surrogate tissues. This book is useful to researchers and scientists interested in applying novel methodologies for identifying biomarkers in the fields of pharmacology, toxicology, and medicine.
Author: Michael E. Burczynski
Publisher: CRC Press
ISBN: 1420038095
Category : Medical
Languages : en
Pages : 329
Get Book
Book Description
Both an introduction and a fundamental reference, this book explores how to apply genomic, proteomic, and metabolomic technologies to surrogate tissue analysis. It reviews fundamental analytical issues and actual initial results generated using these technologies. The book covers transcriptional profiling (genomics), protein profiling (proteomics), methylation profiling (epigenomics), metabolite profiling (metabolomics) and additional biomarker identification methods that can be applied to surrogate tissues. This book is useful to researchers and scientists interested in applying novel methodologies for identifying biomarkers in the fields of pharmacology, toxicology, and medicine.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309157277
Category : Medical
Languages : en
Pages : 335
Get Book
Book Description
Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Author: Svetlana Dambinova
Publisher: Royal Society of Chemistry
ISBN: 1849734747
Category : Science
Languages : en
Pages : 246
Get Book
Book Description
Due to injuries sustained in sports and in combat, interest in TBI has never been greater. Biomarkers for Traumatic Brain Injury will fulfil a gap in our understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging. This knowledge will be useful for all researchers and clinicians interested in the biochemical and structural sequelae underpinning clinical manifestations of TBI and help guide appropriate patient management. Current and prospective biomarkers for the assessment of traumatic brain injury (TBI), particularly mild TBI, are examined using a multidisciplinary approach involving biochemistry, molecular biology, and clinical chemistry. The book incorporates presentations from outstanding researchers and clinicians in the area and describes advanced proteomic and degradomic technologies in the development of novel biomarker assays. For practical purposes, the focus of this volume is on detection of blood-based biomarkers to improve diagnostic certainty of mild TBI in conjunction with radiological and clinical findings. It represents contributions from internationally-recognized researchers at the forefront of traumatic brain injury many of whom are recipients of grants and contracts from the United States Department of Defense for research specifically on developing diagnostic tests for TBI. The book will be essential reading for scientists, pharmacologists, chemists, medical and graduate students.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309187001
Category : Medical
Languages : en
Pages : 141
Get Book
Book Description
In 2010 the Institute of Medicine (IOM) recommended a framework for the evaluation of biomarkers in the chronic disease setting. Published in the book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease, the framework is intended to bring consistency and transparency to the previously disparate process of biomarker evaluation. Following the book's release, the IOM convened a 2-day discussion forum in Washington, DC, in order to provide an opportunity for stakeholders to learn about, react to, and discuss the book. Presentations reviewed the authoring committee's work process, recommendations, and provided perspectives on the book from the point of view of participants. Thomas Fleming, professor of biostatistics and statistics at the University of Washington, gave a keynote presentation on the critical issues in the validation of surrogate endpoints, a specific use of a biomarker. The present volume recounts the discussion forum proceedings, focusing in turn on each represented sector. A summary of Dr. Fleming's presentation then sets the committee's recommendations within the context of biomarker utilization. Lastly, this summary examines the main themes raised by stakeholders, and the challenges and opportunities presented to stakeholders by the book's recommendations.
Author: Kalindi Vora
Publisher: U of Minnesota Press
ISBN: 1452943532
Category : Political Science
Languages : en
Pages : 243
Get Book
Book Description
From call centers, overseas domestic labor, and customer care to human organ selling, gestational surrogacy, and knowledge work, such as software programming, life itself is channeled across the globe from one population to another. In Life Support, Kalindi Vora demonstrates how biological bodies have become a new kind of global biocapital. Vora examines how forms of labor serve to support life in the United States at the expense of the lives of people in India. She exposes the ways in which even seemingly inalienable aspects of human life such as care, love, and trust—as well as biological bodies and organs—are not only commodifiable entities but also components essential to contemporary capitalism. As with earlier modes of accumulation, this new global economy has come to rely on the reproduction of life for expansion. Human bodies and subjects are playing a role similar to that of land and natural resource dispossession in the period of capitalist growth during European territorial colonialism. Indeed, the rapid pace at which scientific knowledge of biology and genetics has accelerated has opened up the human body as an extended site for annexation, harvest, dispossession, and production.
Author: Tomasz Burzykowski
Publisher: Springer Science & Business Media
ISBN: 0387270809
Category : Medical
Languages : en
Pages : 417
Get Book
Book Description
Covers the latest research on a sensitive and controversial topic in a professional and well researched manner. Provides practical outlook as well as model guidelines and software tools that should be of interest to people who use the software tools described and those who do not. Related title by Co-author Geert Molenbergh has sold more than 3500 copies world wide. Provides dual viewpoints: from scientists in the industry as well as regulatory authorities.
Author: Melinda Cooper
Publisher: Duke University Press
ISBN: 0822377004
Category : Social Science
Languages : en
Pages : 290
Get Book
Book Description
Forms of embodied labor, such as surrogacy and participation in clinical trials, are central to biomedical innovation, but they are rarely considered as labor. Melinda Cooper and Catherine Waldby take on that project, analyzing what they call "clinical labor," and asking what such an analysis might indicate about the organization of the bioeconomy and the broader organization of labor and value today. At the same time, they reflect on the challenges that clinical labor might pose to some of the founding assumptions of classical, Marxist, and post-Fordist theories of labor. Cooper and Waldby examine the rapidly expanding transnational labor markets surrounding assisted reproduction and experimental drug trials. As they discuss, the pharmaceutical industry demands ever greater numbers of trial subjects to meet its innovation imperatives. The assisted reproductive market grows as more and more households look to third-party providers for fertility services and sectors of the biomedical industry seek reproductive tissues rich in stem cells. Cooper and Waldby trace the historical conditions, political economy, and contemporary trajectory of clinical labor. Ultimately, they reveal clinical labor to be emblematic of labor in twenty-first-century neoliberal economies.
Author: Margot Note
Publisher: Elsevier
ISBN: 1780630565
Category : Computers
Languages : en
Pages : 233
Get Book
Book Description
This book explores issues surrounding all aspects of visual collection management, taken from real-world experience in creating management systems and digitizing core content. Readers will gain the knowledge to manage the digitization process from beginning to end, assess and define the needs of their particular project, and evaluate digitization options. Additionally, they will select strategies which best meet current and future needs, acquire the knowledge to select the best images for digitization, and understand the legal issues surrounding digitization of visual collections. Offers practical information for the busy information professional Concentrates solely on image management Focuses on unique needs of born digital and digitized images
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309044375
Category : Science
Languages : en
Pages : 224
Get Book
Book Description
The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Author: Ramesh C. Gupta
Publisher: Academic Press
ISBN: 0124046495
Category : Medical
Languages : en
Pages : 1152
Get Book
Book Description
Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more
