Studies Toward the Total Synthesis of (")-chartelline C and ( - )-platensimycin PDF Download

Author: Evan Adam Hecker
Publisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 542

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Book Description
Herein is described our work towards the total synthesis of the marine natural product (")-chartelline C and the potent antibiotic ( - )-platensimycin. Part 1 relates the (")-chartelline C project. The first chapter reviews (")-chartelline C's isolation, biogeneity, and previously reported studies relevant to the area. Chapter 2 tells of our contributions including the development of a convergent, regioselective assembly of an indole-imidazole compound en route to the natural product. Chapter 3 includes the experimental details of this work and the characterization of previously unreported compounds. Part 2 recounts the ( - )-platensimycin research project. Chapter 4 discusses the importance of the natural product and the relevant previous research reported. Chapter 5 describes our efforts in this area, culminating in the stereoselective synthesis of an intermediate closely related to a known compound, which was converted to the natural product. Chapter 6 includes the experimental details of this work and the characterization of previously unreported compounds.