Author: Philippe Gastaud
Publisher:
ISBN:
Category :
Languages : en
Pages : 172
Book Description
Studies Toward an Enantioselective Total Synthesis of (+)-Duocarmycin A
Author: Philippe Gastaud
Publisher:
ISBN:
Category :
Languages : en
Pages : 172
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 172
Book Description
Studies Toward an Enantioselective Total Synthesis of (-)- Aleurodiscal
Author: Todd M. Heidelbaugh
Publisher:
ISBN:
Category :
Languages : en
Pages : 694
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 694
Book Description
Studies Toward the Enantioselective Total Synthesis of Quadrigemine H
Author: Leonard Sung
Publisher:
ISBN: 9780549716709
Category :
Languages : en
Pages : 38
Book Description
Synthetic efforts toward the [3+1] quadrigemine alkaloids are described in this dissertation. Chapter 1 reviews the quadrigemine alkaloids from a historical perspective and discusses methods for the construction of their highly congested vicinal and diaryl all-carbon quaternary stereocenters. The application of these methods is featured in the presentation of the enantioselective syntheses of hodgkinsine and quadrigemine C.
Publisher:
ISBN: 9780549716709
Category :
Languages : en
Pages : 38
Book Description
Synthetic efforts toward the [3+1] quadrigemine alkaloids are described in this dissertation. Chapter 1 reviews the quadrigemine alkaloids from a historical perspective and discusses methods for the construction of their highly congested vicinal and diaryl all-carbon quaternary stereocenters. The application of these methods is featured in the presentation of the enantioselective syntheses of hodgkinsine and quadrigemine C.
Studies Toward the Enantioselective Total Synthesis of Stemonine
Author: Beth Ann Plattner
Publisher:
ISBN:
Category :
Languages : en
Pages : 138
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 138
Book Description
Studies Toward the Enantioselective Total Synthesis of ( - )-Cochleamycin A
Author: Jiyoung Chang
Publisher:
ISBN:
Category : Cochleamycin A
Languages : en
Pages :
Book Description
Abstract: A synthetic approach to the tricyclic ring system of the unnatural enantiomer of cochleamycin A is described. An (E, Z, E)-1,6,8-nonatriene was prepared by coupling two building blocks synthesized from L-( - )-malic and L-( - )-ascorbic acids, respectively. A highly enantioselective synthesis of the fully functionalized AB ring system was achieved by a stereocontrolled intramolecular Diels-Alder reaction that proceeds via an endo transition state. The resulting cis-tetrahydroindane system was examined for its potential along two flexible pathways to construct the CD ring system. Formation of the ten-membered carbocycle was initially explored. Different cyclization methods including the Nozaki-Hiyama-Kishi reaction, ring-closing olefin metathesis, and the Ramberg-Backlund rearrangement were not effective. As an alternative way, ten-membered macrolactone formation was also investigated. C ring formation was achieved by the Yamaguchi macrolactonization protocol. Attempts to complete the D ring system of the target molecule involving reductive cyclization of bromo lactone with a Weinreb amide were unsuccessful. The Nozaki-Hiyama-Kishi reaction of bromo aldehyde 4.27 proved to be unreliable. In one instance, HRMS data was obtained indicating the possible formation of a very small amount of the target tetracyclic system. However, this observation could not be reproduced.
Publisher:
ISBN:
Category : Cochleamycin A
Languages : en
Pages :
Book Description
Abstract: A synthetic approach to the tricyclic ring system of the unnatural enantiomer of cochleamycin A is described. An (E, Z, E)-1,6,8-nonatriene was prepared by coupling two building blocks synthesized from L-( - )-malic and L-( - )-ascorbic acids, respectively. A highly enantioselective synthesis of the fully functionalized AB ring system was achieved by a stereocontrolled intramolecular Diels-Alder reaction that proceeds via an endo transition state. The resulting cis-tetrahydroindane system was examined for its potential along two flexible pathways to construct the CD ring system. Formation of the ten-membered carbocycle was initially explored. Different cyclization methods including the Nozaki-Hiyama-Kishi reaction, ring-closing olefin metathesis, and the Ramberg-Backlund rearrangement were not effective. As an alternative way, ten-membered macrolactone formation was also investigated. C ring formation was achieved by the Yamaguchi macrolactonization protocol. Attempts to complete the D ring system of the target molecule involving reductive cyclization of bromo lactone with a Weinreb amide were unsuccessful. The Nozaki-Hiyama-Kishi reaction of bromo aldehyde 4.27 proved to be unreliable. In one instance, HRMS data was obtained indicating the possible formation of a very small amount of the target tetracyclic system. However, this observation could not be reproduced.
Enantioselective Total Syntheses of Teubrevin G and Teubrevin H and Studies Toward the Enantioselective Total Synthesis of Vinigrol
Author: Ivan V. Efremov
Publisher:
ISBN:
Category :
Languages : en
Pages : 552
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 552
Book Description
Studies Toward the Enantioselective Total Synthesis of (-) Stemonine Samarium Diiodide Mediated Additions of Iodomethyl Oxazoles and Thiazoles to Aldehydes
Author: Bryan Stroup
Publisher:
ISBN:
Category :
Languages : en
Pages : 146
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 146
Book Description
Studies Toward the Enantioselective Synthesis of an Epidithiapiperazinedione Ring and Pummerer Reaction Chemistry
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Catalytic Enantioselective Dearomatization and Studies Towards the Total Synthesis of (-)-morphine
Author: Robert David Matthew Pace
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Enantioselective Total Synthesis of Either Enantiomer of the Antifungal Antibiotic Preussin (L-657,398)
Author: Wei Deng
Publisher:
ISBN:
Category :
Languages : en
Pages : 316
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 316
Book Description