Author: Gabriel N. Kapur
Publisher:
ISBN: 9781109844450
Category :
Languages : en
Pages : 259
Book Description
The northern hemisphere, which had been previously synthesized in our labs, was closely analyzed and synthesized again, with an improvement in the final three steps so that a more isomerically pure product resulted (15:1 now vs. 3:1 before). Finally, a crucial Suzuki coupling reaction of the northern and southern hemispheres was performed, which allowed the diol moiety at C19 and C20 to remain unprotected. This was followed by a saponification reaction to bring us to a very advanced carboxylic acid intermediate, one step from the closed 20-membered macrocycle.
Studies Directed Toward the Total Synthesis of (-)-apoptolidin
Author: Gabriel N. Kapur
Publisher:
ISBN: 9781109844450
Category :
Languages : en
Pages : 259
Book Description
The northern hemisphere, which had been previously synthesized in our labs, was closely analyzed and synthesized again, with an improvement in the final three steps so that a more isomerically pure product resulted (15:1 now vs. 3:1 before). Finally, a crucial Suzuki coupling reaction of the northern and southern hemispheres was performed, which allowed the diol moiety at C19 and C20 to remain unprotected. This was followed by a saponification reaction to bring us to a very advanced carboxylic acid intermediate, one step from the closed 20-membered macrocycle.
Publisher:
ISBN: 9781109844450
Category :
Languages : en
Pages : 259
Book Description
The northern hemisphere, which had been previously synthesized in our labs, was closely analyzed and synthesized again, with an improvement in the final three steps so that a more isomerically pure product resulted (15:1 now vs. 3:1 before). Finally, a crucial Suzuki coupling reaction of the northern and southern hemispheres was performed, which allowed the diol moiety at C19 and C20 to remain unprotected. This was followed by a saponification reaction to bring us to a very advanced carboxylic acid intermediate, one step from the closed 20-membered macrocycle.
Studies Directed Toward the Total Synthesis of ( - )-apoptolidin A
Author: Venkatesan Srinivasan
Publisher:
ISBN:
Category :
Languages : en
Pages : 872
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 872
Book Description
Studies Toward the Total Synthesis of ( - )-Apoptolidin
Author: Christina Goudreau Collison
Publisher:
ISBN:
Category :
Languages : en
Pages : 358
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 358
Book Description
Studies Toward the Total Synthesis of Apoptolidin
Author: Bin Wu
Publisher:
ISBN:
Category :
Languages : en
Pages : 550
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 550
Book Description
Studies on the Total Synthesis of ( - )-apoptolidin
Author: Xiaorong Liu
Publisher:
ISBN:
Category :
Languages : en
Pages : 524
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 524
Book Description
Part I. Studies Towards the Total Synthesis of (-)-Apoptolidin A ; Part II. Hydroxymethylation of Aldehydes and Its Application to (-)-Rasfonin
Author: Douglas J. Tusch
Publisher:
ISBN:
Category :
Languages : en
Pages : 240
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 240
Book Description
I. Design and Synthesis of Cysteine Protease Inhibitors. II. Total Synthesis of (-)-bafilomycin A1 III. Studies Directed Towards the Total Synthesis of Apoptolidin
Author: Karl A. Scheidt
Publisher:
ISBN:
Category :
Languages : en
Pages : 652
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 652
Book Description
Studies Directed Toward the Total Synthesis of Vernolepin
Author: Charles Garabed Chavdarian
Publisher:
ISBN:
Category :
Languages : en
Pages : 478
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 478
Book Description
Progress Towards the Total Synthesis of Apoptolidin
Author: Bohan Jin
Publisher:
ISBN:
Category :
Languages : en
Pages : 604
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 604
Book Description
The Total Synthesis of Leucascandrolide A ; Studies Directed Toward the Total Synthesis of Ingenol
Author: Keith Hornberger
Publisher:
ISBN:
Category :
Languages : en
Pages : 452
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 452
Book Description