Structural Templates for Protein Design: the Assembly of Peptidyl Motifs with Defined Supersecondary Structure PDF Download
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Author: Mary Denise Struthers
Publisher:
ISBN:
Category :
Languages : en
Pages : 608
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Author: Mary Denise Struthers
Publisher:
ISBN:
Category :
Languages : en
Pages : 608
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Author: Raphael Guerois
Publisher: Springer Science & Business Media
ISBN: 1597451169
Category : Science
Languages : en
Pages : 303
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Book Description
Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.
Author: Norbert Sewald
Publisher: John Wiley & Sons
ISBN: 3527802657
Category : Science
Languages : en
Pages : 771
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Book Description
Der "Sewald/Jakubke" ist und bleibt das einzige moderne, auf dem neuesten wissenschaftlichen Stand gehaltene fortgeschrittene Lehrbuch der Peptid-Biochemie! Auch für diese zweite, um ein Viertel erweitere Auflage haben die Autoren Hunderte von Publikationen gelesen und zu einem informativen und vollständigen Überblick über das Fachgebiet zusammengefasst. Nach einer Einführung in die Grundlagen der Peptidstruktur und -synthese werden die wichtigsten Familien biologisch aktiver Peptide systematisch abgehandelt. Mit interdisziplinärem Anspruch werden dann wichtige Anwendungen aus der Biotechnologie, Pharmazie und Biomedizin besprochen. Selbstverständlich werden auch Themen der Spitzenforschung berücksichtigt, zum Beispiel Pseudopeptide, Peptidmimetika und Aspekte der kombinatorischen Synthese. -- Neu in dieser Auflage sind Fragen und Übungsaufgaben, die das Nacharbeiten von Vorlesungen oder das Selbststudium erleichtern.
Author: Owen Lancaster
Publisher:
ISBN:
Category :
Languages : en
Pages : 224
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Author: Rossen Donev
Publisher: Elsevier
ISBN: 0323992293
Category : Science
Languages : en
Pages : 432
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Book Description
Protein Design and Structure, Volume 130 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Includes the latest information on protein design and structure
Author: Dan Ethan McNamara
Publisher:
ISBN:
Category :
Languages : en
Pages : 355
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Book Description
All aspects of life are controlled by proteins which often assemble into complex arrangements. Research on natural and unnatural protein assemblies enhances our understanding of biological science. The research described here provides structural and mechanistic insights into how protein assemblies could be utilized to improve or develop novel protein functions. Bacterial protein assemblies, microtubule-targeting compounds, and designed protein assemblies were investigated with X-ray crystallography and our results may further the understanding of these targets in pursuit of therapeutics for cancer, obesity, and other conditions. The first study revealed an unexpectedly large structure and putative mechanism for the enzyme DmrB that may help in the design of anti-obesity drugs targeting gut bacteria. A second effort helped to explain how the outer shells of huge bacterial microcompartments may assemble together. The research carried out may help better implement efforts underway to engineer more stable microcompartments for new biotechnology approaches. Structural studies of the interactions which mediate enzyme encapsulation in bacterial microcompartments were also pursued. Our results establish methods for the isolation and subsequent characterization of binary and potentially ternary complexes of microcompartment shell proteins and luminal enzymes. Current tubulin-targeting cancer therapeutics suffer from many drawbacks underscoring the need to further understand the structure of eukaryotic protein assemblies such as microtubules. We describe the structural characterization of two recently-identified compounds that potently kill cancer cell lines. High-throughput screening identified MI-181 and C2 in contexts of mitotic inhibition and cancer cell-death. X-ray crystal structures of MI-181 and C2 bound to a complex containing -tubulin, tubulin tyrosine ligase, and the tubulin-binding protein stathmin revealed details of how these compounds interact with -tubulin subunits. These structures clarify the unknown binding properties and may guide the improvement of these compounds as candidates for therapeutics or chemical probes for better understanding cell division. In addition to natural protein assemblies, unnatural symmetric protein materials can be achieved through protein design. We have solved crystal structures of four computationally-designed protein assemblies. Additional structural studies of designed proteins revealed structures of sequences engineered to form cyclic oligomers and three-dimensional lattice symmetries. These structures emphasize the design accuracy that can be achieved using computational methods in favorable cases. These most recent designed assemblies are built from two distinct components, a strategy that lends itself to versatile construction of functional nanomaterials for a variety of applications. Furthermore, we have developed an additional new method to design two-component protein assemblies which may be engineered for new functions. Fusion of a self-associating heterologous pair of helical elements to symmetric oligomers can be implemented in a way that generates three-dimensional closed systems or extended arrays of protein. Protein engineering applications are proposed and intial designs are described for several biotechnology purposes. Self-assembling protein designs will contain short peptide ligands for cancer-related growth receptors. Designs in which symmetric oligomers self-assemble into extended rod-like filaments were tested for this application. Proper assembly was investigated with electron microscopy after purification from bacteria. The coiled-coil fusion design approach identified candidates for novel nanomaterials which may induce cellular responses related to cell growth and cancer in cultured endothelial cells. Finally, improving the properties of key enzymes can overcome limitations of in vitro metabolic engineering systems. Enzymes for synthesizing isoprene - a starting compound for generating a variety of value-added products - are a useful test-bed. We incorporated a dimeric plant enzyme for isoprene synthesis into the design of a single-layer array of self-assembling symmetric oligomeric enzymes. Two designs are described which enable the isolation of two components separately which may self-assemble upon mixing to form a two-dimensional layer.
Author: Owen Lancaster
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 712
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![Schematikon, an Encyclopedia of Structural Motifs in Proteins [microform] PDF](https://books.google.com/books/content/images/frontcover/fmf5tgAACAAJ?fife=w80-h100)
Author: Bhooma Thiruvahindrapuram
Publisher: Library and Archives Canada = Bibliothèque et Archives Canada
ISBN: 9780494021415
Category :
Languages : en
Pages : 206
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Book Description
We have compiled a comprehensive dictionary of local structural motifs and their corresponding sequence patterns. We start from the hypothesis that frequently recurring structural patterns correspond to low energy conformations, which arise due to specific residue interactions and conformational preferences. As source data we have defined a dataset of non-homologous structures. We define and identify "motifs" as local maxima of density, by applying a procedure called "kernel density estimation". The sequence profiles for motifs with strong sequence preferences are compiled. Our encyclopedia consists of 982 motifs, over 90% of these show significant sequence preference at least one position. The average coverage of protein domains in the non-homologous dataset was found to be 65%. We have identified several of the previously described structural motifs and some novel patterns. The anticipated uses include applications in protein engineering, structure annotation, structure prediction from sequence and detailed studies of sequence-structure relationships.
Author: Chaim A. Schramm
Publisher:
ISBN:
Category :
Languages : en
Pages : 176
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