Author: Raj Deepak Pai
Publisher:
ISBN:
Category :
Languages : en
Pages : 374

Get Book Here

Book Description

Author: Marina V. Rodnina
Publisher: Springer Science & Business Media
ISBN: 3709102154
Category : Medical
Languages : en
Pages : 428

Get Book Here

Book Description
The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

Author: Roger A. Garrett
Publisher: Amer Society for Microbiology
ISBN: 9781555811846
Category : Medical
Languages : en
Pages : 565

Get Book Here

Book Description
Complete coverage of the ribosome and mechanisms of protein synthesis. * Examines the structure and function of numerous extra-chromosomal factors. * Offers the first detailed account of crystal structures of the ribosome as well as insights into the mechanisms and action of antibiotics. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Author: Christopher Swanson
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 0

Get Book Here

Book Description
The mechanism of action of argyrin B and the molecular interactions of L11 and L12 has been undetermined and underrepresented in the research of bacterial translation. This work seeks to examine the mechanism of action of argyrin B by performing in vitro structural studies of its interaction with its specific target protein elongation factor-G. We demonstrate that argyrin B inhibits translation, and allows GTPase activity to proceed, contrary to assumptions made in prior research. We determine that ribosome recycling is the likely step through which argyrin B acts as an antibiotic, since translocation is unaffected by argyrin B and association with post-termination complexes are increased in the presence of argyrin B. We propose that the mechanism of action involves the ratcheting of EF-G 45 ° from a normal binding conformation with the ribosome, which sterically hinders the positioning of loop II of domain IV of EF-G and the cooperativity of EF-G and RRF in interrupting Bridge 2a, the largest intersubunit bridge on the ribosome. Furthermore, we provide preliminary insight on the molecular interactions present between L11 and the L12 C Terminal Domain by performing alanine scanning mutations on select glutamic acid and aspartic acid residues around an electronegatively charged pocket. These mutations while not effecting L11 binding in a tangible way, strongly influenced select GTPase activity.

Author: Knud H. Nierhaus
Publisher: John Wiley & Sons
ISBN: 3527616381
Category : Science
Languages : en
Pages : 597

Get Book Here

Book Description
Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.

Author: Walter Ensign Hill
Publisher: ASM Press
ISBN:
Category : Science
Languages : en
Pages : 716

Get Book Here

Book Description
This book is recommended as a 'hitchhiker's guide to the ribosome' for everyone with an interest in translation, RNA-protein structures, and macromolecular structure-function relationships Science >.

Author: Eleanor Spicer Ward
Publisher:
ISBN:
Category : Ribosomes
Languages : en
Pages : 468

Get Book Here

Book Description

Author: Alexander Spirin
Publisher: Springer Science & Business Media
ISBN: 1461578175
Category : Science
Languages : en
Pages : 417

Get Book Here

Book Description
This book is based on an advanced course of lectures on ribosome structure and protein biosynthesis that I offer at the Moscow State University. These lectures have been part of a general course on molecular biology for almost three decades, and they have undergone considerable evolution as knowledge has been pro gressing in this field. The progress continues, and readers should be prepared that some facts, statements, and ideas included in the book may be incomplete or out of-date. In any case, this is primarily a textbook, but not a comprehensive review. It provides a background of knowledge and current ideas in the field and gives ex amples of observations and their interpretations. I understand that some interpre tations and generalizations may be tentative or disputable, but I hope that this will stimulate thinking and discussing better than if I left white spots. The book has a prototype: it is my monograph "Ribosome Structure and Pro tein Biosynthesis" published by the Benjamin/Cummings Publishing Company, Menlo Park, California, in 1986. Here I have basically kept the former order of pre sentation ofthe topics and the subdivision into chapters. The contents ofthe chap ters, however, have been significantly revised and supplemented. The newly writ ten chapters on translational control in prokaryotes (Chapter 16) and eukaryotes (Chapter 17) are added.

Author: Scott M. Stagg
Publisher:
ISBN:
Category :
Languages : en
Pages : 256

Get Book Here

Book Description

Author: Boyd Hardesty
Publisher: Springer Science & Business Media
ISBN: 1461248841
Category : Science
Languages : en
Pages : 832

Get Book Here

Book Description
During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramati cally different. We have an almost bewildering variety of information de tailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for replicating, distributing, and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids, and smaller mole cules work together to provide the molecular setting of living systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of mono graphs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field.