Structural Studies of Terminal Protein-primed DNA Replication by Phi29 DNA Polymerase PDF Download
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Author: Andrea Jeanne Berman
Publisher:
ISBN: 9780549064886
Category :
Languages : en
Pages : 166
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Book Description
Sequence-independent DNA binding and the mechanism of translocation in B-family polymerases were examined in DNA substrate complexes of phi29 DNA polymerase. These complexes included the translocated binary complex and the post-insertion pre-translocation ternary complex. Comparison of these structures revealed a mechanism of translocation, different from the mechanism for A-family polymerases, based on the coordinated movement of two conserved tyrosine residues.
Author: Andrea Jeanne Berman
Publisher:
ISBN: 9780549064886
Category :
Languages : en
Pages : 166
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Book Description
Sequence-independent DNA binding and the mechanism of translocation in B-family polymerases were examined in DNA substrate complexes of phi29 DNA polymerase. These complexes included the translocated binary complex and the post-insertion pre-translocation ternary complex. Comparison of these structures revealed a mechanism of translocation, different from the mechanism for A-family polymerases, based on the coordinated movement of two conserved tyrosine residues.
Author: Jeffrey Richard Salerno
Publisher:
ISBN:
Category :
Languages : en
Pages : 110
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Book Description
Author: Walter Doerfler
Publisher: Springer Science & Business Media
ISBN: 3662055996
Category : Medical
Languages : en
Pages : 369
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Book Description
After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens. After the first volume on virion and structure, viral replication and host-cell interaction this second volume deals with the immune system, oncogenesis and gene therapy.
Author: Ulrich Huebscher
Publisher: Springer
ISBN: 9781468487312
Category :
Languages : en
Pages : 584
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Book Description
Author: Melvin L. DePamphilis
Publisher: CSHL Press
ISBN: 9780879694593
Category : Medical
Languages : en
Pages : 1080
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Book Description
National Institutes of Health. Cold Spring Harbor Monograph, Volume 31 Extensive text on the replication of DNA, specifically in eukaryotic cells, for researchers. 68 contributors, 54 U.S.
Author: Michael G. Rossmann
Publisher: Springer Science & Business Media
ISBN: 1461409802
Category : Medical
Languages : en
Pages : 685
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Book Description
This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chapters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will examine in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion. Each chapter will describe the components of the respective machine in molecular or atomic detail, genetic and biochemical analyses, and mechanism. Topics are carefully selected so that the reader is exposed to systems where there is a substantial infusion of new knowledge in recent years, which greatly elevated the fundamental mechanistic understanding of the respective molecular machine. The authors will be encouraged to simplify the detailed knowledge to basic concepts, include provocative new ideas, as well as design colorful graphics, thus making the cutting-edge information accessible to broad audience.
Author: J. Robin Harris
Publisher: Springer Nature
ISBN: 3030589714
Category : Science
Languages : en
Pages : 580
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Book Description
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Henryk Czosnek
Publisher: Springer Science & Business Media
ISBN: 140204769X
Category : Science
Languages : en
Pages : 437
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Book Description
Ideally suited to horticulturalists and plant virologists, this highly useful text offers a multidisciplinary view on one of the major diseases of tomato crops, the tomato yellow leaf curl disease. It deals with epidemiological aspects of the disease as well as integrated pest management in the field. Coverage discusses the efforts aimed at breeding tomato plants resistant to the virus by classical breeding, by marker-assisted breeding and by genetic engineering.
Author: Satya Prakash Gupta
Publisher: Academic Press
ISBN: 0128154233
Category : Science
Languages : en
Pages : 498
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Book Description
Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs. - Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition - Analyzes the structure-activity relationships of inhibitors of each viral polymerase - Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets
Author: Pierre Pontarotti
Publisher: Springer Science & Business Media
ISBN: 3642382126
Category : Science
Languages : en
Pages : 295
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Book Description
This book presents 19 selected contributions to the 16th Evolutionary Biology Meeting, which took place in September 2012 in Marseilles. The aims of these annual meetings, which gather together leading evolutionary biologists and other scientists, are to promote the exchange of ideas and to encourage interdisciplinary collaborations. The first chapter deals with the history of a great discovery: The first experiments on ascidian and sea urchin egg fertilization. The remaining contributions are grouped under the following categories: · Evolutionary biology concepts · Exobiology and the origin of life · Evolutionary mechanisms Offering an up-to-date overview of recent findings in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.
