Author: G. S. Ladde
Publisher: CRC Press
ISBN: 0824758757
Category : Mathematics
Languages : en
Pages : 269
Book Description
This peerless reference/text unfurls a unified and systematic study of the two types of mathematical models of dynamic processes-stochastic and deterministic-as placed in the context of systems of stochastic differential equations. Using the tools of variational comparison, generalized variation of constants, and probability distribution as its methodological backbone, Stochastic Versus Deterministic Systems of Differential Equations addresses questions relating to the need for a stochastic mathematical model and the between-model contrast that arises in the absence of random disturbances/fluctuations and parameter uncertainties both deterministic and stochastic.
Stochastic versus Deterministic Systems of Differential Equations
Author: G. S. Ladde
Publisher: CRC Press
ISBN: 0824758757
Category : Mathematics
Languages : en
Pages : 269
Book Description
This peerless reference/text unfurls a unified and systematic study of the two types of mathematical models of dynamic processes-stochastic and deterministic-as placed in the context of systems of stochastic differential equations. Using the tools of variational comparison, generalized variation of constants, and probability distribution as its methodological backbone, Stochastic Versus Deterministic Systems of Differential Equations addresses questions relating to the need for a stochastic mathematical model and the between-model contrast that arises in the absence of random disturbances/fluctuations and parameter uncertainties both deterministic and stochastic.
Publisher: CRC Press
ISBN: 0824758757
Category : Mathematics
Languages : en
Pages : 269
Book Description
This peerless reference/text unfurls a unified and systematic study of the two types of mathematical models of dynamic processes-stochastic and deterministic-as placed in the context of systems of stochastic differential equations. Using the tools of variational comparison, generalized variation of constants, and probability distribution as its methodological backbone, Stochastic Versus Deterministic Systems of Differential Equations addresses questions relating to the need for a stochastic mathematical model and the between-model contrast that arises in the absence of random disturbances/fluctuations and parameter uncertainties both deterministic and stochastic.
Stochastic Versus Deterministic Systems Of Iterative Processes
Author: Gangaram S Ladde
Publisher: World Scientific
ISBN: 981128749X
Category : Mathematics
Languages : en
Pages : 355
Book Description
Continuous state dynamic models can be reformulated into discrete state processes. This process generates numerical schemes that lead theoretical iterative schemes. This type of method of stochastic modelling generates three basic problems. First, the fundamental properties of solution, namely, existence, uniqueness, measurability, continuous dependence on system parameters depend on mode of convergence. Second, the basic probabilistic and statistical properties, namely, the behavior of mean, variance, moments of solutions are described as qualitative/quantitative properties of solution process. We observe that the nature of probability distribution or density functions possess the qualitative/quantitative properties of iterative prosses as a special case. Finally, deterministic versus stochastic modelling of dynamic processes is to what extent the stochastic mathematical model differs from the corresponding deterministic model in the absence of random disturbances or fluctuations and uncertainties.Most literature in this subject was developed in the 1950s, and focused on the theory of systems of continuous and discrete-time deterministic; however, continuous-time and its approximation schemes of stochastic differential equations faced the solutions outlined above and made slow progress in developing problems. This monograph addresses these problems by presenting an account of stochastic versus deterministic issues in discrete state dynamic systems in a systematic and unified way.
Publisher: World Scientific
ISBN: 981128749X
Category : Mathematics
Languages : en
Pages : 355
Book Description
Continuous state dynamic models can be reformulated into discrete state processes. This process generates numerical schemes that lead theoretical iterative schemes. This type of method of stochastic modelling generates three basic problems. First, the fundamental properties of solution, namely, existence, uniqueness, measurability, continuous dependence on system parameters depend on mode of convergence. Second, the basic probabilistic and statistical properties, namely, the behavior of mean, variance, moments of solutions are described as qualitative/quantitative properties of solution process. We observe that the nature of probability distribution or density functions possess the qualitative/quantitative properties of iterative prosses as a special case. Finally, deterministic versus stochastic modelling of dynamic processes is to what extent the stochastic mathematical model differs from the corresponding deterministic model in the absence of random disturbances or fluctuations and uncertainties.Most literature in this subject was developed in the 1950s, and focused on the theory of systems of continuous and discrete-time deterministic; however, continuous-time and its approximation schemes of stochastic differential equations faced the solutions outlined above and made slow progress in developing problems. This monograph addresses these problems by presenting an account of stochastic versus deterministic issues in discrete state dynamic systems in a systematic and unified way.
Stochastic Ordinary and Stochastic Partial Differential Equations
Author: Peter Kotelenez
Publisher: Springer Science & Business Media
ISBN: 0387743170
Category : Mathematics
Languages : en
Pages : 452
Book Description
Stochastic Partial Differential Equations analyzes mathematical models of time-dependent physical phenomena on microscopic, macroscopic and mesoscopic levels. It provides a rigorous derivation of each level from the preceding one and examines the resulting mesoscopic equations in detail. Coverage first describes the transition from the microscopic equations to the mesoscopic equations. It then covers a general system for the positions of the large particles.
Publisher: Springer Science & Business Media
ISBN: 0387743170
Category : Mathematics
Languages : en
Pages : 452
Book Description
Stochastic Partial Differential Equations analyzes mathematical models of time-dependent physical phenomena on microscopic, macroscopic and mesoscopic levels. It provides a rigorous derivation of each level from the preceding one and examines the resulting mesoscopic equations in detail. Coverage first describes the transition from the microscopic equations to the mesoscopic equations. It then covers a general system for the positions of the large particles.
Linear Systems Control
Author: Elbert Hendricks
Publisher: Springer Science & Business Media
ISBN: 3540784861
Category : Technology & Engineering
Languages : en
Pages : 555
Book Description
Modern control theory and in particular state space or state variable methods can be adapted to the description of many different systems because it depends strongly on physical modeling and physical intuition. The laws of physics are in the form of differential equations and for this reason, this book concentrates on system descriptions in this form. This means coupled systems of linear or nonlinear differential equations. The physical approach is emphasized in this book because it is most natural for complex systems. It also makes what would ordinarily be a difficult mathematical subject into one which can straightforwardly be understood intuitively and which deals with concepts which engineering and science students are already familiar. In this way it is easy to immediately apply the theory to the understanding and control of ordinary systems. Application engineers, working in industry, will also find this book interesting and useful for this reason. In line with the approach set forth above, the book first deals with the modeling of systems in state space form. Both transfer function and differential equation modeling methods are treated with many examples. Linearization is treated and explained first for very simple nonlinear systems and then more complex systems. Because computer control is so fundamental to modern applications, discrete time modeling of systems as difference equations is introduced immediately after the more intuitive differential equation models. The conversion of differential equation models to difference equations is also discussed at length, including transfer function formulations. A vital problem in modern control is how to treat noise in control systems. Nevertheless this question is rarely treated in many control system textbooks because it is considered to be too mathematical and too difficult in a second course on controls. In this textbook a simple physical approach is made to the description of noise and stochastic disturbances which is easy to understand and apply to common systems. This requires only a few fundamental statistical concepts which are given in a simple introduction which lead naturally to the fundamental noise propagation equation for dynamic systems, the Lyapunov equation. This equation is given and exemplified both in its continuous and discrete time versions. With the Lyapunov equation available to describe state noise propagation, it is a very small step to add the effect of measurements and measurement noise. This gives immediately the Riccati equation for optimal state estimators or Kalman filters. These important observers are derived and illustrated using simulations in terms which make them easy to understand and easy to apply to real systems. The use of LQR regulators with Kalman filters give LQG (Linear Quadratic Gaussian) regulators which are introduced at the end of the book. Another important subject which is introduced is the use of Kalman filters as parameter estimations for unknown parameters. The textbook is divided into 7 chapters, 5 appendices, a table of contents, a table of examples, extensive index and extensive list of references. Each chapter is provided with a summary of the main points covered and a set of problems relevant to the material in that chapter. Moreover each of the more advanced chapters (3 - 7) are provided with notes describing the history of the mathematical and technical problems which lead to the control theory presented in that chapter. Continuous time methods are the main focus in the book because these provide the most direct connection to physics. This physical foundation allows a logical presentation and gives a good intuitive feel for control system construction. Nevertheless strong attention is also given to discrete time systems. Very few proofs are included in the book but most of the important results are derived. This method of presentation makes the text very readable and gives a good foundation for reading more rigorous texts. A complete set of solutions is available for all of the problems in the text. In addition a set of longer exercises is available for use as Matlab/Simulink ‘laboratory exercises’ in connection with lectures. There is material of this kind for 12 such exercises and each exercise requires about 3 hours for its solution. Full written solutions of all these exercises are available.
Publisher: Springer Science & Business Media
ISBN: 3540784861
Category : Technology & Engineering
Languages : en
Pages : 555
Book Description
Modern control theory and in particular state space or state variable methods can be adapted to the description of many different systems because it depends strongly on physical modeling and physical intuition. The laws of physics are in the form of differential equations and for this reason, this book concentrates on system descriptions in this form. This means coupled systems of linear or nonlinear differential equations. The physical approach is emphasized in this book because it is most natural for complex systems. It also makes what would ordinarily be a difficult mathematical subject into one which can straightforwardly be understood intuitively and which deals with concepts which engineering and science students are already familiar. In this way it is easy to immediately apply the theory to the understanding and control of ordinary systems. Application engineers, working in industry, will also find this book interesting and useful for this reason. In line with the approach set forth above, the book first deals with the modeling of systems in state space form. Both transfer function and differential equation modeling methods are treated with many examples. Linearization is treated and explained first for very simple nonlinear systems and then more complex systems. Because computer control is so fundamental to modern applications, discrete time modeling of systems as difference equations is introduced immediately after the more intuitive differential equation models. The conversion of differential equation models to difference equations is also discussed at length, including transfer function formulations. A vital problem in modern control is how to treat noise in control systems. Nevertheless this question is rarely treated in many control system textbooks because it is considered to be too mathematical and too difficult in a second course on controls. In this textbook a simple physical approach is made to the description of noise and stochastic disturbances which is easy to understand and apply to common systems. This requires only a few fundamental statistical concepts which are given in a simple introduction which lead naturally to the fundamental noise propagation equation for dynamic systems, the Lyapunov equation. This equation is given and exemplified both in its continuous and discrete time versions. With the Lyapunov equation available to describe state noise propagation, it is a very small step to add the effect of measurements and measurement noise. This gives immediately the Riccati equation for optimal state estimators or Kalman filters. These important observers are derived and illustrated using simulations in terms which make them easy to understand and easy to apply to real systems. The use of LQR regulators with Kalman filters give LQG (Linear Quadratic Gaussian) regulators which are introduced at the end of the book. Another important subject which is introduced is the use of Kalman filters as parameter estimations for unknown parameters. The textbook is divided into 7 chapters, 5 appendices, a table of contents, a table of examples, extensive index and extensive list of references. Each chapter is provided with a summary of the main points covered and a set of problems relevant to the material in that chapter. Moreover each of the more advanced chapters (3 - 7) are provided with notes describing the history of the mathematical and technical problems which lead to the control theory presented in that chapter. Continuous time methods are the main focus in the book because these provide the most direct connection to physics. This physical foundation allows a logical presentation and gives a good intuitive feel for control system construction. Nevertheless strong attention is also given to discrete time systems. Very few proofs are included in the book but most of the important results are derived. This method of presentation makes the text very readable and gives a good foundation for reading more rigorous texts. A complete set of solutions is available for all of the problems in the text. In addition a set of longer exercises is available for use as Matlab/Simulink ‘laboratory exercises’ in connection with lectures. There is material of this kind for 12 such exercises and each exercise requires about 3 hours for its solution. Full written solutions of all these exercises are available.
Introduction To Differential Equations, An: Deterministic Modeling, Methods And Analysis (Volume 1)
Author: Anilchandra G Ladde
Publisher: World Scientific Publishing Company
ISBN: 9813100605
Category : Mathematics
Languages : en
Pages : 542
Book Description
Volume 2: Stochastic Modeling, Methods, and Analysis This is a twenty-first century book designed to meet the challenges of understanding and solving interdisciplinary problems. The book creatively incorporates “cutting-edge” research ideas and techniques at the undergraduate level. The book also is a unique research resource for undergraduate/graduate students and interdisciplinary researchers. It emphasizes and exhibits the importance of conceptual understandings and its symbiotic relationship in the problem solving process. The book is proactive in preparing for the modeling of dynamic processes in various disciplines. It introduces a “break-down-the problem” type of approach in a way that creates “fun” and “excitement”. The book presents many learning tools like “step-by-step procedures (critical thinking)”, the concept of “math” being a language, applied examples from diverse fields, frequent recaps, flowcharts and exercises. Uniquely, this book introduces an innovative and unified method of solving nonlinear scalar differential equations. This is called the “Energy/Lyapunov Function Method”. This is accomplished by adequately covering the standard methods with creativity beyond the entry level differential equations course.
Publisher: World Scientific Publishing Company
ISBN: 9813100605
Category : Mathematics
Languages : en
Pages : 542
Book Description
Volume 2: Stochastic Modeling, Methods, and Analysis This is a twenty-first century book designed to meet the challenges of understanding and solving interdisciplinary problems. The book creatively incorporates “cutting-edge” research ideas and techniques at the undergraduate level. The book also is a unique research resource for undergraduate/graduate students and interdisciplinary researchers. It emphasizes and exhibits the importance of conceptual understandings and its symbiotic relationship in the problem solving process. The book is proactive in preparing for the modeling of dynamic processes in various disciplines. It introduces a “break-down-the problem” type of approach in a way that creates “fun” and “excitement”. The book presents many learning tools like “step-by-step procedures (critical thinking)”, the concept of “math” being a language, applied examples from diverse fields, frequent recaps, flowcharts and exercises. Uniquely, this book introduces an innovative and unified method of solving nonlinear scalar differential equations. This is called the “Energy/Lyapunov Function Method”. This is accomplished by adequately covering the standard methods with creativity beyond the entry level differential equations course.
Stochastic Modelling of Reaction–Diffusion Processes
Author: Radek Erban
Publisher: Cambridge University Press
ISBN: 1108572995
Category : Mathematics
Languages : en
Pages : 322
Book Description
This practical introduction to stochastic reaction-diffusion modelling is based on courses taught at the University of Oxford. The authors discuss the essence of mathematical methods which appear (under different names) in a number of interdisciplinary scientific fields bridging mathematics and computations with biology and chemistry. The book can be used both for self-study and as a supporting text for advanced undergraduate or beginning graduate-level courses in applied mathematics. New mathematical approaches are explained using simple examples of biological models, which range in size from simulations of small biomolecules to groups of animals. The book starts with stochastic modelling of chemical reactions, introducing stochastic simulation algorithms and mathematical methods for analysis of stochastic models. Different stochastic spatio-temporal models are then studied, including models of diffusion and stochastic reaction-diffusion modelling. The methods covered include molecular dynamics, Brownian dynamics, velocity jump processes and compartment-based (lattice-based) models.
Publisher: Cambridge University Press
ISBN: 1108572995
Category : Mathematics
Languages : en
Pages : 322
Book Description
This practical introduction to stochastic reaction-diffusion modelling is based on courses taught at the University of Oxford. The authors discuss the essence of mathematical methods which appear (under different names) in a number of interdisciplinary scientific fields bridging mathematics and computations with biology and chemistry. The book can be used both for self-study and as a supporting text for advanced undergraduate or beginning graduate-level courses in applied mathematics. New mathematical approaches are explained using simple examples of biological models, which range in size from simulations of small biomolecules to groups of animals. The book starts with stochastic modelling of chemical reactions, introducing stochastic simulation algorithms and mathematical methods for analysis of stochastic models. Different stochastic spatio-temporal models are then studied, including models of diffusion and stochastic reaction-diffusion modelling. The methods covered include molecular dynamics, Brownian dynamics, velocity jump processes and compartment-based (lattice-based) models.
Introduction To Differential Equations, An: Stochastic Modeling, Methods And Analysis (Volume 2)
Author: Anilchandra G Ladde
Publisher: World Scientific Publishing Company
ISBN: 9814397393
Category : Mathematics
Languages : en
Pages : 634
Book Description
Volume 1: Deterministic Modeling, Methods and Analysis For more than half a century, stochastic calculus and stochastic differential equations have played a major role in analyzing the dynamic phenomena in the biological and physical sciences, as well as engineering. The advancement of knowledge in stochastic differential equations is spreading rapidly across the graduate and postgraduate programs in universities around the globe. This will be the first available book that can be used in any undergraduate/graduate stochastic modeling/applied mathematics courses and that can be used by an interdisciplinary researcher with a minimal academic background. An Introduction to Differential Equations: Volume 2 is a stochastic version of Volume 1 (“An Introduction to Differential Equations: Deterministic Modeling, Methods and Analysis”). Both books have a similar design, but naturally, differ by calculi. Again, both volumes use an innovative style in the presentation of the topics, methods and concepts with adequate preparation in deterministic Calculus. Errata Errata (32 KB)
Publisher: World Scientific Publishing Company
ISBN: 9814397393
Category : Mathematics
Languages : en
Pages : 634
Book Description
Volume 1: Deterministic Modeling, Methods and Analysis For more than half a century, stochastic calculus and stochastic differential equations have played a major role in analyzing the dynamic phenomena in the biological and physical sciences, as well as engineering. The advancement of knowledge in stochastic differential equations is spreading rapidly across the graduate and postgraduate programs in universities around the globe. This will be the first available book that can be used in any undergraduate/graduate stochastic modeling/applied mathematics courses and that can be used by an interdisciplinary researcher with a minimal academic background. An Introduction to Differential Equations: Volume 2 is a stochastic version of Volume 1 (“An Introduction to Differential Equations: Deterministic Modeling, Methods and Analysis”). Both books have a similar design, but naturally, differ by calculi. Again, both volumes use an innovative style in the presentation of the topics, methods and concepts with adequate preparation in deterministic Calculus. Errata Errata (32 KB)
Deterministic and Stochastic Optimal Control
Author: Wendell H. Fleming
Publisher: Springer Science & Business Media
ISBN: 1461263808
Category : Mathematics
Languages : en
Pages : 231
Book Description
This book may be regarded as consisting of two parts. In Chapters I-IV we pre sent what we regard as essential topics in an introduction to deterministic optimal control theory. This material has been used by the authors for one semester graduate-level courses at Brown University and the University of Kentucky. The simplest problem in calculus of variations is taken as the point of departure, in Chapter I. Chapters II, III, and IV deal with necessary conditions for an opti mum, existence and regularity theorems for optimal controls, and the method of dynamic programming. The beginning reader may find it useful first to learn the main results, corollaries, and examples. These tend to be found in the earlier parts of each chapter. We have deliberately postponed some difficult technical proofs to later parts of these chapters. In the second part of the book we give an introduction to stochastic optimal control for Markov diffusion processes. Our treatment follows the dynamic pro gramming method, and depends on the intimate relationship between second order partial differential equations of parabolic type and stochastic differential equations. This relationship is reviewed in Chapter V, which may be read inde pendently of Chapters I-IV. Chapter VI is based to a considerable extent on the authors' work in stochastic control since 1961. It also includes two other topics important for applications, namely, the solution to the stochastic linear regulator and the separation principle.
Publisher: Springer Science & Business Media
ISBN: 1461263808
Category : Mathematics
Languages : en
Pages : 231
Book Description
This book may be regarded as consisting of two parts. In Chapters I-IV we pre sent what we regard as essential topics in an introduction to deterministic optimal control theory. This material has been used by the authors for one semester graduate-level courses at Brown University and the University of Kentucky. The simplest problem in calculus of variations is taken as the point of departure, in Chapter I. Chapters II, III, and IV deal with necessary conditions for an opti mum, existence and regularity theorems for optimal controls, and the method of dynamic programming. The beginning reader may find it useful first to learn the main results, corollaries, and examples. These tend to be found in the earlier parts of each chapter. We have deliberately postponed some difficult technical proofs to later parts of these chapters. In the second part of the book we give an introduction to stochastic optimal control for Markov diffusion processes. Our treatment follows the dynamic pro gramming method, and depends on the intimate relationship between second order partial differential equations of parabolic type and stochastic differential equations. This relationship is reviewed in Chapter V, which may be read inde pendently of Chapters I-IV. Chapter VI is based to a considerable extent on the authors' work in stochastic control since 1961. It also includes two other topics important for applications, namely, the solution to the stochastic linear regulator and the separation principle.
Chaotic Transitions in Deterministic and Stochastic Dynamical Systems
Author: Emil Simiu
Publisher: Princeton University Press
ISBN: 1400832500
Category : Mathematics
Languages : en
Pages : 244
Book Description
The classical Melnikov method provides information on the behavior of deterministic planar systems that may exhibit transitions, i.e. escapes from and captures into preferred regions of phase space. This book develops a unified treatment of deterministic and stochastic systems that extends the applicability of the Melnikov method to physically realizable stochastic planar systems with additive, state-dependent, white, colored, or dichotomous noise. The extended Melnikov method yields the novel result that motions with transitions are chaotic regardless of whether the excitation is deterministic or stochastic. It explains the role in the occurrence of transitions of the characteristics of the system and its deterministic or stochastic excitation, and is a powerful modeling and identification tool. The book is designed primarily for readers interested in applications. The level of preparation required corresponds to the equivalent of a first-year graduate course in applied mathematics. No previous exposure to dynamical systems theory or the theory of stochastic processes is required. The theoretical prerequisites and developments are presented in the first part of the book. The second part of the book is devoted to applications, ranging from physics to mechanical engineering, naval architecture, oceanography, nonlinear control, stochastic resonance, and neurophysiology.
Publisher: Princeton University Press
ISBN: 1400832500
Category : Mathematics
Languages : en
Pages : 244
Book Description
The classical Melnikov method provides information on the behavior of deterministic planar systems that may exhibit transitions, i.e. escapes from and captures into preferred regions of phase space. This book develops a unified treatment of deterministic and stochastic systems that extends the applicability of the Melnikov method to physically realizable stochastic planar systems with additive, state-dependent, white, colored, or dichotomous noise. The extended Melnikov method yields the novel result that motions with transitions are chaotic regardless of whether the excitation is deterministic or stochastic. It explains the role in the occurrence of transitions of the characteristics of the system and its deterministic or stochastic excitation, and is a powerful modeling and identification tool. The book is designed primarily for readers interested in applications. The level of preparation required corresponds to the equivalent of a first-year graduate course in applied mathematics. No previous exposure to dynamical systems theory or the theory of stochastic processes is required. The theoretical prerequisites and developments are presented in the first part of the book. The second part of the book is devoted to applications, ranging from physics to mechanical engineering, naval architecture, oceanography, nonlinear control, stochastic resonance, and neurophysiology.
Deterministic Versus Stochastic Modelling in Biochemistry and Systems Biology
Author: Paola Lecca
Publisher: Elsevier
ISBN: 1908818212
Category : Mathematics
Languages : en
Pages : 411
Book Description
Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Following an overview of deterministic chemical kinetics and the stochastic approach to biochemical kinetics, the book goes onto discuss the specifics of stochastic simulation algorithms, modelling in systems biology and the structure of biochemical models. Later chapters cover reaction-diffusion systems, and provide an analysis of the Kinfer and BlenX software systems. The final chapter looks at simulation of ecodynamics and food web dynamics. Introduces mathematical concepts and formalisms of deterministic and stochastic modelling through clear and simple examples Presents recently developed discrete stochastic formalisms for modelling biological systems and processes Describes and applies stochastic simulation algorithms to implement a stochastic formulation of biochemical and biological kinetics
Publisher: Elsevier
ISBN: 1908818212
Category : Mathematics
Languages : en
Pages : 411
Book Description
Stochastic kinetic methods are currently considered to be the most realistic and elegant means of representing and simulating the dynamics of biochemical and biological networks. Deterministic versus stochastic modelling in biochemistry and systems biology introduces and critically reviews the deterministic and stochastic foundations of biochemical kinetics, covering applied stochastic process theory for application in the field of modelling and simulation of biological processes at the molecular scale. Following an overview of deterministic chemical kinetics and the stochastic approach to biochemical kinetics, the book goes onto discuss the specifics of stochastic simulation algorithms, modelling in systems biology and the structure of biochemical models. Later chapters cover reaction-diffusion systems, and provide an analysis of the Kinfer and BlenX software systems. The final chapter looks at simulation of ecodynamics and food web dynamics. Introduces mathematical concepts and formalisms of deterministic and stochastic modelling through clear and simple examples Presents recently developed discrete stochastic formalisms for modelling biological systems and processes Describes and applies stochastic simulation algorithms to implement a stochastic formulation of biochemical and biological kinetics